高效液相色谱法测定骨健口服液中丹参素的含量

目的建立骨健口服液中丹参素的含量测定方法。方法高效液相色谱法。色谱柱ZorbaxEclipseXDB-C18(4.6×150mm,5μm);流动相水-甲醇-磷酸(97∶3∶0.05);检测波长280nm;流速0.91ml/min柱温25℃。结果丹参素在0.20μg~2.00μg范围内,线性关系良好,回归方程为Y=684144.2436X 0.0000(r=1.000),平均加样回收率为97.88%,RSD=1.50%(n=6)。结论本方法操作简便、准确快速、重现性好,可用于骨健口服液中的质量控制。     

牙槽外科术中应用气动牙钻解除骨与牙阻力效果临床观察

目的探讨在牙槽外科对各类阻生牙、埋伏牙、根端肥大、弯根、根分叉大等牙齿位置与牙根形态异常的患牙拔除术中,运用气动牙钻解除骨阻力、牙阻力的临床可行性、操作方法、术后并发症及疗效分析。方法979颗需拔除的患牙,随机分为两组,采用气动牙钻磨切法(实验组)508颗,传统凿骨劈分法(对照组)471颗。经过完善的术前准备,正确分析骨阻力、牙阻力并设计切割线/劈开线,解除阻力后拔除。结果实验组508颗患牙经过气动牙钻或种植机磨切解除骨阻力、牙阻力后均在短时间内顺利拔除,并发症明显少于对照组。结论在复杂拔牙等牙槽外科手术中,运用高速涡轮钻、低速气动牙钻或种植机,藉其精确、便捷、高效的切割磨削功能,单独或联合应用于去骨、分牙、分根,与传统的凿骨劈开法相比具有操作方法简单,创伤小,出血少,易于控制去骨量,能精确分隔牙体,使原本复杂的手术变为简单,可缩短手术时间,消除患者恐惧心理,减少术后不良反应和并发症,临床疗效好,适宜推广使用。     

下颌骨骨母细胞瘤1例报告

患者,男,11岁,下颌骨疼痛5个月而就诊。查体:舌下口底水肿,颏区触及一硬结,约4cm×3.5cm。Zllz叩诊。一般情况良好,实验室检查未见异常。X线检查:下颌骨颏部有3.5cm×2.5cm的一类圆形高密度影,边缘清楚,硬化,病灶内部密度不均,有散在的点片状高密度影,边缘不甚清晰,X线诊断:下颌骨良性肿瘤。手术所见:瘤体呈灰白色疏松组织,约3cm×2.2cm×2.5cm大小,舌侧及颏部下缘骨板破坏。病理诊断:下颌骨良性骨母细胞瘤。讨论骨母细胞瘤又称巨骨样瘤或成骨细胞瘤,系一种少见、单发、良性、有丰富的血管、有骨样组织形成以及丰富的成骨细胞为特点的肿瘤…     

股骨髁上骨牵引治疗转子间骨折70例

自1993年12月-2003年11月，我们应用股骨髁上骨牵引治疗转子间骨折70例，取得较好效果。现报道如下。     

膝关节滑膜骨软骨瘤病的临床X线表现(附6例报告)

滑膜骨软骨瘤是一种较少见的关节疾病,系滑膜良性肿瘤。我院分析2001~2004年收集的膝关节滑膜骨软骨瘤病的临床X线表现,报告如下。1材料与方法本组6例中,男5例,女1例。其中4例为单侧发病,2例为双侧发病,无外伤史。使用F78-Ⅱ型300mA X光机,投照条件:100mA,50kV。6例均作膝关节正侧位片,并根据其X线表现结合临床资料及病理证实。2结果本组5例膝关节内及关节周围见多数圆形或卵圆形结节状钙化或骨化影。直径2mm~2cm不等,密度均匀。1例关节内未见明显钙化或骨化征象(图2)。3讨论滑膜骨软骨瘤病大多起源于关节的滑膜,也起自滑囊和腱鞘的滑膜[…     

警惕药物诱发溃疡病

胃是人体重要的消化器官之一，其功能主要是受纳摄入的食物，通过运动将食物与胃液混合成为半液体状后逐步排入十二指肠。胃液含盐酸，具有杀菌作用。胃腔内附着的黏膜上皮细胞分泌黏液，起到保护胃黏膜的作用。口服药在吸收后，首先要崩解经过胃液的混合，再转送到小肠吸收发挥作用。如果滥服乱用药物，有些药物酸、碱性较强，能对胃黏膜产生强烈的刺激，形成胃壁黏膜水肿、炎症、出血，直至糜烂、溃疡甚至穿孔。临床上由于长期大剂量使用药物而引起的急性胃炎、胃及十二指肠溃疡等疾病屡见不鲜。     

NSCLC患者血清肿瘤标志物水平与肿瘤骨转移之间关系的研究

目的:探讨非小细胞肺癌患者治疗前血清肿瘤标志物水平与肿瘤骨转移之间的相关性。材料和方法:受检患者58名治疗前均行血清Cy21-1、SCC、NSE、CEA和CA15-3测定和SPECT全身骨显像。结果:血清Cy21-1和CA15-3水平与全身骨显像结果相关。(P<0.05),血清SCC,NSE及CEA水平则无相关(P>0.05)。结论:血清中Cy21-1和CA15-3升高水平与肿瘤骨转移之间存在正相关关系,尤以Cy21-1为著。     

SPECT/CT同机图像融合诊断股骨头缺血性坏死

目的 评价SPECT/CT同机图像融合技术诊断股骨头缺血性坏死的临床应用价值.方法 53例临床可疑股骨头缺血性坏死患者行全身骨显像及骨盆局部SPECT/CT断层显像并对SPECT和CT同机图像进行重建与融合.结果 ①融合图像诊断阳性率高于断层图像及平面图像,差异具有显著性;②融合图像对早期病变诊断阳性率高于断层显像及平面显像,差异具有显著性.结论 SPECT/CT同机图像融合技术对于股骨头缺血性坏死的早期诊断、鉴别诊断及疾病分期均有一定的临床价值.     

兔动静脉短路环法诱导组织工程骨支架材料血管生成的初步研究

Objective To compare the effects of 2 vascular carriers, arteriovenous loop and arteri-ovenous bundle, on inducing angiogenesis in coral scaffold of vascularized tissue-engineered bone in animal models.Methods Thirty-six adult male New Zealand rabbits were randomized into 2 even groups.In group A, an arteriovenous loop (AVL) was formed by microsurgical anastomosis at the proximal ends between the femoral poptiteal artery and vein, and placed in the circular side groove of the coral block (6 mm × 8 mm × 10 mm) .In group B, flow-through vessels bundles of both femoral artery and vein were placed in the side grooves of the coral block.All the implants in 2 groups were wrapped by a micro-porous expand-ed-polytetrafluoroethylene (ePTFE) membrane, and fixed subcutaneously by suturing.Evaluation methods included gross morphological observations, histological examinations, India ink perfusion and vascular casting after 2, 4, 6 weeks.The density of blood vessels was analyzed by the statistical software SPSS 10.0.Results All the corals were encased by newly formed fibrovascular tissues in 2 groups.Ink-stained vessels distributed the surfaces and side grooves, and invaded the interspaces of corals.The degree of vascularization increased over the course of experiment.Blood vessel density demonstrated a significant continuous increase between 2 and 6 weeks after implantation in group A.The mean value of blood vessel density in group A (2 weeks 276.60±4.67, 4 weeks 517.20±10.66, 6 weeks 707.00 ±11.87) was significantly higher than in group B (2 weeks 153.60 ±7.16, 4 weeks 269.40±6.80, 6 weeks 279.20±6.53) (P <0.01).Vascular casting showed that in group A, significant blood vessels sprouted from all areas of the loop, espe-cially at the entrance of the arteriovenous pediele where the small tubes were densely interconnected.In group B, however, no blood vessels sprouted from the arteriovenous bundles and only some small vessels grew from the entrance and exit.Conclusions A vascularized coral model can be constructed by inserting an ar-teriovenous loop or an arteriovenous bundle, useful in vascular bone tissue engineering.The former, however, have stronger abilities to induce angiogenesis than the latter.     

未涉及关节的跟骨骨折的非手手术疗法

跟骨骨折是跗骨中常见的骨折，多由垂直暴力造成，治疗方法多种多样，手术疗法与非手术疗法各有所长，若治疗不当常常会留有很多后遗症，严重影响功能。手术切开复位虽然能够在直视下复位，却也由于损伤了跟距关节周围的组织，破坏关节的稳定性，增加了局部的瘢痕形成，且切口有裂开及感染的可能，手术效果多不令人满意。笔者采用非手术疗法治疗未涉及关节的跟骨骨折48例取得满意效果。现报告如下：