含铋剂四联疗法根除幽门螺杆菌疗效观察

目的 探讨合铋剂四联疗法治疗消化性溃疡Hp感染初治者的疗效.方法 将138例消化性溃疡Hp感染初治者随机分成治疗组和对照组.治疗组70例患者给予胶体果胶铋+泮托拉唑+克拉霉素+阿莫西林;对照组68例患者给予泮托拉唑+克拉霉素+阿莫西林.两组患者均完成1周治疗,治疗结束后4周对根除Hp的疗效进行观察.结果 治疗组和对照组Hp根除率分别为87.14％(61/70)和73.53％(50/68),差异有统计学意义(ｘ2=4.06,P＜0.05).结论 含铋剂四联疗法用于消化性溃疡Hp感染初治者的疗效好于标准三联疗法.     

枇杷果渣果胶最佳提取条件研究

目的 研究从枇杷果渣中提取果胶的最佳条件.方法 以不同的酸进行酸解,再进行正交试验以优化提取条件.结果 亚硫酸（H2SO3）是最适宜的酸解剂.结论 从枇杷果渣中提取果胶的最佳条件为：pH1.5、提取温度95℃、提取时间2.0h、固液比1∶30,在该条件下,果胶得率为15.29％,经脱色、脱蛋白、透析、盐沉淀、脱盐、洗涤干燥后,果胶得率为9.50％.     

The Influence of the Hydrophobic Polymeric Coating on 5-ASA Release from the Bipolymeric Milibeads with Amidated Pectin

The industrial polymeric carriers for peroral mesalazine application exploit, i.a., cellulose or polyacrylic acid derivatives, polyvinylpyrrolidone, and modified starch. Pectins, as natural polymers, are interesting materials in pharmaceutical applications due to properties such as non-toxicity, biocompatibility, and biodegradability. The aim of the study was the evaluation of the release of the drug from coated pectin beads doped with synthetic polymers as drug carriers to the colon, as well as interactions between ingredients. The drug release was carried out using basket apparatus. The amount of 5-ASA (5-aminosalicylic acid, mesalazine) released to the pH = 7.4 buffer with pectinase was measured at selected time intervals using UV-Vis spectroscopy. The zero-, first-, and second-order kinetics, as well as Higuchi, Korsmeyer–Peppas, and Hixon–Crowell equations, were used to analyze the release pattern. The interactions between beads components were investigated employing FTIR spectrophotometry and DSC study. The dissolution of the drug was divided into two parts. It was found that the release of 5-ASA followed mainly the Higuchi equation. The mass transport in the first stage of the release followed a non-Fickian model and the parameter n was in the range of 0.74 ± 0.2–0.99 ± 0.2. The formulation doped with PA (polyacrylic acid) was the most appropriate and capable of overcoming the variable conditions of the gastrointestinal tract.     

胶体果胶铋、阿莫西林、雷贝拉唑联合治疗消化性溃疡效果观察

目的观察胶体果胶铋、阿莫西林联合雷贝拉唑治疗消化性溃疡的临床效果。方法将180例消化性溃疡患者随机分为两组,将治疗组92例采用药物联合治疗与对照组88例单一药品治疗的效果进行比较。结果治疗组痊愈率为94．57％,对照组痊愈率为81．82％,两组差异具有统计学意义。结论胶体果胶铋、阿莫西林、雷贝拉唑联合可减少炎症反应,保护溃疡面,促进溃疡组织再生的修复作用。     

Microwave modified non-crosslinked pectin films with modulated drug release

The effects of microwave on drug release properties of pectin films carrying sulfanilamide (SN-P), sulfathiazole (ST-P) and sulfamerazine (SM-P) of high to low aqueous solubilities were investigated. These films were prepared by solvent evaporation technique and treated by microwave at 80?W for 5–40?min. Their profiles of drug dissolution, drug content, matrix interaction and matrix crystallinity were determined by drug dissolution testing, drug content assay, differential scanning calorimetry, X-ray diffractometry and scanning electron microscopy techniques. Microwave induced an increase in matrix amorphousness but lower drug release propensity with a greater retardation extent in SN-P films, following a rise in strength of matrix interaction. A gain in amorphous structure does not necessarily increase the drug release of film. Microwave can possibly retard drug release of pectin film carrying water-soluble drug through modulating its state of matrix interaction.     

Green Banana Protection of Gastric Mucosa against Experimentally Induced Injuries in Rats

The protective capacities of fresh green (unripe) sweet bananas and of phosphatidylcholine and pectin (banana ingredients) against acute (ethanol- or indomethacin-induced) and chronic (indomethacin-induced) gastric mucosal lesions were evaluated in rats. Banana pulp was mixed with saline and given by gavage, as a pretreatment in a single dose. The identical protocol was used for pectin and phosphatidylcholine solution, and the dosages were adjusted to equal the amount of ingredients in the banana mixture, but higher concentrations were also given. The banana suspension reduced acute lesions, as did pectin and phosphatidylcholine in higher concentrations, but in concentrations as in fresh fruit no protective effects were observed except by pectin against indomethacin injury. In the model of chronic ulcers the banana suspension provided an incomplete and temporary protective effect. We conclude that the protective capacity of fresh green sweet bananas cannot be confined to only one active component. Pectin and phosphatidylcholine may protect gastric mucosa by strengthening the mucous-phospholipid layer, but the mechanism of protection afforded by bananas has to be further elucidated.     

5-氨基水杨酸结肠定位柱塞型脉冲胶囊的制备与体外释放

目的:制备5-氨基水杨酸结肠定位柱塞型脉冲胶囊并对其体外释药行为进行评价。方法:用灌注法制备非渗透性胶囊体,粉末直接压片法压制柱塞片,湿法制粒法制备含药速崩片,将速崩片与柱塞片密封于非渗透性胶囊体内制备脉冲胶囊,考察影响释药时滞的各种因素。结果:胶囊在体外呈明显的脉冲释放,释药时滞随柱塞片中高酯果胶-乳糖或羟丙甲纤维素-低酯果胶比例的增加而增加,具有相同处方柱塞片的脉冲胶囊在模拟结肠溶出介质中释药时滞明显缩短,当高酯果胶-乳糖为4∶6和6∶4,低酯果胶/羟丙甲纤维素为9.5∶0.5和9∶1时,可达到结肠定位所需的4~5h释药时滞。结论:调节柱塞片处方组成可获得具有适当释药时滞的脉冲胶囊,以满足结肠定位释药的目的。     

替普瑞酮联合果胶铋对胃溃疡患者TGF-β和Smad3的影响

目的 研究替普瑞酮联合果胶铋对胃溃疡患者TGF-β和Smad3的影响。方法 选择2015-09-01~2017-02-28在延安市中医医院进行治疗的胃溃疡患者126例,根据治疗方案不同分为观察组和对照组,对照组给予替普瑞酮治疗,观察组以对照组为基础联合果胶铋治疗,两组均治疗4周,治疗后观察两组临床疗效。同时观察比较两组治疗前后血清炎性因子变化,分析胃窦黏膜中TGF-β与Smad3的表达。结果 治疗后观察组总有效率(93.7%)明显高于对照组(81.0%)(P<0.05);与治疗前相比,两组血清CRP、IL-6、TNF-α水平明显降低(P<0.05);与对照组相比,观察组血清炎性因子水平较低(P<0.05)。治疗后两组TGF-β与Smad3表达均显著下降,且观察组下降幅度明显优于对照组(P<0.05)。 结论 使用替普瑞酮联合果胶铋治疗胃溃疡,可显著缓解临床症状,提高其治疗效果,同时可降低TGF-β与Smad3表达。     

果胶对猪血氨的影响

目的　正确评定可溶性纤维———果胶在猪的营养价值。方法　选择体重约2 5kg的健康生长猪4头,在猪的门静脉、颈动脉安装血管插管,采用交叉法,随机分为2组,试验组加入8%果胶,对照组不加果胶,在采食前( 0h)、采食后1、2、3、4、5、6、7h抽取动、静脉血液,测定血氨浓度。结果试验组门静脉血氨浓度低于对照组,在3h时差异有显著意义(P <0 .0 5 ) ;试验组颈动脉血氨浓度与对照组比差异无显著性(P >0 .0 5 ) ;试验组动静脉血氨浓度差在采食后均低于对照组,在1h、3h、4h时差异有显著性(P <0 .0 5 )。结论　在采食后7小时内,果胶有降低猪血氨的作用。     

阿莫西林联合果胶铋治疗慢性萎缩性胃炎的疗效

目的 分析阿莫西林联合果胶铋治疗慢性萎缩性胃炎的临床疗效.方法 86例慢性萎缩性胃炎患者,以随机双盲的方式分为研究组与对照组,每组43例.对照组患者采用阿莫西林治疗,研究组患者采用阿莫西林联合果胶铋治疗.比较两组患者的治疗效果,病理积分,不良反应发生情况.结果 研究组患者的治疗总有效率97.67％高于对照组的76.74...