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91.
2型糖尿病糖耐量实验与胰岛素释放实验关系的探讨 总被引:1,自引:0,他引:1
目的 探讨2型糖尿病血糖与胰岛素释放的关系,以及血糖水平对血糖刺激的胰岛素释放的影响.方法 对50例2型糖尿病患者停用口服药24 h后,口服75 g葡萄糖行葡萄糖耐量实验(OGTT)及胰岛素释放实验(IRT).血糖采用cobas Integra 400 plus全自动生化分析仪测定,胰岛素采用美国Becoman Coulter Access2化学发光仪测定.结果 50例2型糖尿病患者按血糖水平与胰岛素释放的变化方向可分为4组:①A组:血糖水平与胰岛素水平曲线平行,均于1 h达峰值16例.②B组:胰岛素水平峰值延迟9例.③C组:血糖水平与胰岛素水平均于2 h达峰值,峰值延迟19例.④D组:血糖峰值延迟6例.结论 血糖水平与血清胰岛素水平呈负相关,但由于胰岛B细胞的个体差异很大,可以出现不同的分离现象,体现了糖尿病发病的异质性或个体差异性. 相似文献
92.
Queenie Mae Torrente Alban Killingback Philip J Adds Claire Robertson 《International Journal of Sports Physical Therapy》2022,17(4):636
BackgroundMaintenance of patellar stability requires a balance between the vastus medialis oblique (VMO) and the vastus lateralis (VL). The imbalance between these muscles is thought to be implicated in the etiology of patellofemoral pain (PFP). Where there is hypertrophy of the VL in PFP patients, self-myofascial release (SMR) may be utilized for its management. However, there is no current evidence regarding SMR and its effects on VMO and VL architecture. The aim of this study, therefore, was to use ultrasound to gain further understanding of the effects of a program of SMR on the fiber angles of the VMO and VL.HypothesisThere will be a significant decrease in the pennation angles of the VMO and VL after seven weeks of SMR using a foam roller.Study DesignCohort StudyMethodsTwenty-five young, athletic, male participants were recruited to use a foam roller, along the full length of both anterior thighs, three times weekly, on three separate days, for seven weeks. Ultrasound was used to determine the initial and final VMO and VL pennation angles on both limbs. One eligible participant was chosen as an intra-rater control and did not partake in the SMR regimen.ResultsThere was a statistically significant (p < 0.001) decrease in the pennation angles of the VMO and VL after the SMR regime. Mean combined right and left VL angle change was -6.65° (-18% mean change) and the mean combined right and left VMO angle change was -7.65° (-11.5% mean change). A weak negative correlation was found between initial VMO fiber angle and the angle change (Rsquared = -0.21), as well as moderate negative correlation for the VL (Rsquared = -0.51).ConclusionA program of SMR on the anterior thighs of young, asymptomatic males resulted in changes to the fiber angles of both the VMO and VL. There was a significant decrease in pennation angle after seven weeks of SMR using a foam roller. 相似文献
93.
94.
目的 探讨腕管镜腕管松解术和改良小切口腕管松解术治疗糖尿病腕管综合征的临床疗效和安全性差异.方法 回顾性分析腕管综合征合并糖尿病患者86例,其中43例患者行双孔道腕管镜腕管松解术(A组),43例患者行改良小切口腕管松解术(B组),随访10 ~ 24个月,统计两组患者的手术时间、住院时间、恢复工作时间、术后并发症和临床疗效.结果 A组和B组患者的优良率分别为93.02%和90.70%,两组的优良率比较差异无统计学意义(P>0.05);A组患者的住院时间[(5.5±2.7)vs(6.8±2.9)d]及术后恢复工作时间[(19.3±3.1)vs(21.5±3.3)d]少于B组,差异有统计学意义(P<0.05),而两组患者的手术时间、术后并发症发生率比较均差异无统计学意义(P>0.05).结论 腕管镜腕管松解法和改良小切口腕管松解法均是治疗糖尿病腕管综合征的有效且安全的手术方法,腕管镜腕管减压术患者住院时间短、术后恢复快,对于机体修补能力较差的糖尿病患者更为适合. 相似文献
95.
Ajmal Zarinwall Viktor Maurer Jennifer Pierick Victor Marcus Oldhues Julian Cedric Porsiel Jan Henrik Finke Georg Garnweitner 《Drug delivery》2022,29(1):2086
Promising active pharmaceutical ingredients (APIs) often exhibit poor aqueous solubility and thus a low bioavailability that substantially limits their pharmaceutical application. Hence, efficient formulations are required for an effective translation into highly efficient drug products. One strategy is the preservation of an amorphous state of the API within a carrier matrix, which leads to enhanced dissolution. In this work, mesoporous silica aerogels (SA) were utilized as a carrier matrix for the amorphization of the poorly water-soluble model drug ibuprofen. Loading of tailored SA was performed post-synthetically and solvent-free, either by co-milling or via the melting method. Thorough analyses of these processes demonstrated the influence of macrostructural changes during the drying and grinding process on the microstructural properties of the SA. Furthermore, interfacial SA-drug interaction properties were selectively tuned by attaching terminal hydrophilic amino- or hydrophobic methyl groups to the surface of the gel. We demonstrate that not only the chemical surface properties of the SA, but also formulation-related parameters, such as the carrier-to-drug ratio, as well as process-related parameters, such as the drug loading method, decisively influence the ibuprofen adsorption efficiency. In addition, the drug-loaded SA formulations exhibited a remarkable physical stability over a period of 6 months. Furthermore, the release behavior is shown to change considerably with different surface properties of the SA matrix. Hence, the reported results demonstrate that utilizing specifically processed and modified SA offers a compelling technique for enhancement of the bioavailability of poorly-water soluble APIs and a versatile adjustment of their release profile. 相似文献
96.
Rationale:Oblique lumbar interbody fusion (OLIF) is an effective and safe surgical technique widely used for treating spondylolisthesis; however, its use is controversial because of several associated complications, including endplate injury. We report a rare vertebral body fracture following OLIF in a patient with poor bone quality.Patient concerns:A 72-year-old male patient visited our clinic for 2 years with lower back pain, leg radiating pain, and intermittent neurogenic claudication.Diagnoses:Lumbar magnetic resonance imaging revealed L4-5 stenosis.Intervention:We performed OLIF with percutaneous pedicle screw fixation and L4 subtotal decompressive laminectomy. We resected the anterior longitudinal ligament partially for anterior column release and inserted a huge cage to maximize segmental lordosis. No complications during and after the operation were observed. Further, the radiating pain and back pain improved, and the patient was discharged. Two weeks after the operation, the patient visited the outpatient department complaining of sudden recurred pain, which occurred while going to the bathroom. Radiography and computed tomography revealed a split fracture of the L5 body and an anterior cage displacement. In revision of OLIF, we removed the dislocated cage and filled the bone cement between the anterior longitudinal ligament and empty disc space. Further, we performed posterior lumbar interbody fusion L4-5, and the screw was extended to S1.Outcomes:After the second surgery, back pain and radiating pain in the left leg improved, and he was discharged without complications.Lesson:In this case, owing to insufficient intervertebral space during L4-5 OLIF, a huge cage was used to achieve sufficient segmental lordosis after anterior column release, but a vertebral body coronal fracture occurred. In patients with poor bone quality and less flexibility, a huge cage and over-distraction could cause a vertebral fracture; hence, selecting an appropriate cage or considering a posterior approach is recommended. 相似文献
97.
目的:探讨情绪释放疗法对腹腔镜子宫肌瘤剔除术病人疼痛程度、不良情绪及术后恢复的影响。方法:选择2019年11月—2021年6月医院c4病区收治的腹腔镜子宫肌瘤剔除术病人80例,随机分为对照组与观察组,各40例。对照组行常规干预,观察组行情绪释放疗法干预。比较两组病人手术后疼痛程度、不良情绪、术后恢复效果及满意度。结果:干预后观察组病人术后6 h、24 h的视觉模拟评分法(VAS)评分明显低于对照组(P<0.05);观察组病人术后2 d的汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分明显低于对照组(P<0.05);观察组病人术后肛门首次排气时间、腹胀消失时间、术后首次排便时间、肠鸣音恢复时间、首次下床时间、术后住院时间均明显短于对照组(P<0.05);观察组病人术后满意度明显高于对照组(P<0.05)。结论:情绪释放疗法能明显缓解腹腔镜子宫肌瘤剔除术病人疼痛程度,减轻其不良情绪,提升满意度,促进术后早日康复。 相似文献
98.
99.
G. Decorti Luigi Candussio Fiora Bartoli Klugmann Antonella Strohmayer Maria Pia Mucci Alessandro Mosco Luciano Baldini 《Cancer chemotherapy and pharmacology》1997,40(4):363-366
It has been proven that the anthracyclines induce an important, noncytotoxic histamine release from rat peritoneal mast cells.
As mast cells derived from different tissues exhibit marked heterogeneity, the effect of Adriamycin in comparison with other
antineoplastic agents was tested on fragments of the right heart auricle, which contain a great number of mast cells. In this
experimental model, Adriamycin induced a dose-dependent histamine release that was significantly limited by the antiexocytotic
drug sodium cromoglycate. The antineoplastic agents cisplatin and 5-fluorouracil, in contrast, did not provoke any comparable
histamine release. In the formulation employed in clinical settings, paclitaxel was also capable of inducing a histamine release
comparable with that of Adriamycin; the exocytotic activity, however, was also evident when the tissue fragments were treated
with Cremophor EL alone, without the addition of paclitaxel, whereas treatment of samples with paclitaxel dissolved in ethanol
did not induce any releasing action. These data thus suggest that the secretory activity should be ascribed to the solvent
Cremophor EL and not to paclitaxel. The release of histamine induced by paclitaxel in Cremophor EL/ethanol was also limited
by sodium cromoglycate. These results again indicate that histamine release from mast cells derived not only from the peritoneal
cavity but also from the cardiac tissue could play a role in the cardiotoxicity of anthracyclines and of paclitaxel in the
clinically employed formulation.
Received: 18 August 1996 / Accepted: 22 December 1996 相似文献
100.
目的:建立泛昔洛韦(FCV)缓释微丸体内血药浓度的测定方法并进行体内药动学研究。方法:以甲醇和0.02mol/L磷酸二氢钾(9∶91)为流动相,选择6条家犬口服泛昔洛韦缓释微丸375mg后,利用高效液相色谱法(HPLC)测定6条家犬的血药浓度并对其进行药动学的研究。结果:本法的线性范围为0.1-10μg/ml,r=0.9943,日内及日间RSD均小于10%。FCV缓释微丸在体内的代谢产物喷昔洛韦(PCV)的tmax为(4.80±0.84)h,Cmax为(2.61±1.37)mg/L,AUC0→∞为(25.59±7.58)mg/h/L,MRT为(9.85±2.47)h。结论:本方法简便快速,无干扰,重现性好,可用于泛昔洛韦在体内的药动学研究,并且通过本实验的体内测定方法得到了家犬体内的药动学参数。 相似文献