全文获取类型
收费全文 | 48514篇 |
免费 | 4614篇 |
国内免费 | 1110篇 |
专业分类
耳鼻咽喉 | 246篇 |
儿科学 | 2019篇 |
妇产科学 | 1222篇 |
基础医学 | 3031篇 |
口腔科学 | 1677篇 |
临床医学 | 12502篇 |
内科学 | 4302篇 |
皮肤病学 | 291篇 |
神经病学 | 4172篇 |
特种医学 | 1599篇 |
外国民族医学 | 9篇 |
外科学 | 7342篇 |
综合类 | 4727篇 |
现状与发展 | 1篇 |
一般理论 | 5篇 |
预防医学 | 2736篇 |
眼科学 | 645篇 |
药学 | 3910篇 |
65篇 | |
中国医学 | 2341篇 |
肿瘤学 | 1396篇 |
出版年
2024年 | 94篇 |
2023年 | 1068篇 |
2022年 | 1309篇 |
2021年 | 2363篇 |
2020年 | 2385篇 |
2019年 | 2446篇 |
2018年 | 2291篇 |
2017年 | 2239篇 |
2016年 | 2069篇 |
2015年 | 1937篇 |
2014年 | 3627篇 |
2013年 | 4376篇 |
2012年 | 2667篇 |
2011年 | 2927篇 |
2010年 | 2342篇 |
2009年 | 2113篇 |
2008年 | 2354篇 |
2007年 | 2080篇 |
2006年 | 1874篇 |
2005年 | 1571篇 |
2004年 | 1326篇 |
2003年 | 1154篇 |
2002年 | 983篇 |
2001年 | 886篇 |
2000年 | 701篇 |
1999年 | 633篇 |
1998年 | 516篇 |
1997年 | 516篇 |
1996年 | 411篇 |
1995年 | 346篇 |
1994年 | 346篇 |
1993年 | 274篇 |
1992年 | 265篇 |
1991年 | 216篇 |
1990年 | 148篇 |
1989年 | 163篇 |
1988年 | 137篇 |
1987年 | 143篇 |
1986年 | 124篇 |
1985年 | 156篇 |
1984年 | 125篇 |
1983年 | 101篇 |
1982年 | 110篇 |
1981年 | 98篇 |
1980年 | 73篇 |
1979年 | 37篇 |
1978年 | 28篇 |
1977年 | 23篇 |
1976年 | 30篇 |
1975年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 156 毫秒
21.
22.
Purpose
Chest wall pain is an uncommon but bothersome late complication following lung stereotactic body radiation therapy. Despite numerous studies investigating predictors of chest wall pain, no clear consensus has been established for a chest wall constraint. The aim of our study was to investigate factors related to chest wall pain in a homogeneous group of patients treated at our institution.Patients and methods
All 122 patients were treated with the same stereotactic body radiation therapy regimen of 48 Gy in three fractions, seen for at least 6 months of follow-up, and planned with heterogeneity correction. Chest wall pain was scored according to the Common Terminology Criteria for Adverse Events classification v3.0. Patient (age, sex, diabetes, osteoporosis), tumour (planning target volume, volume of the overlapping region between planning target volume and chest wall) and chest wall dosimetric parameters (volumes receiving at least 30, 40, and 50 Gy, the minimal doses received by the highest irradiated 1, 2, and 5 cm3, and maximum dose) were collected. The correlation between chest wall pain (grade 2 or higher) and the different parameters was evaluated using univariate and multivariate logistic regression.Results
Median follow-up was 18 months (range: 6–56 months). Twelve patients out of 122 developed chest wall pain of any grade (seven with grade 1, three with grade 2 and two with grade 3 pain). In univariate analysis, only the volume receiving 30 Gy or more (P = 0.034) and the volume of the overlapping region between the planning target volume and chest wall (P = 0.038) significantly predicted chest wall pain, but these variables were later proved non-significant in multivariate regression.Conclusion
Our analysis could not find any correlation between the studied parameters and chest wall pain. Considering our present study and the wide range of differing results from the literature, a reasonable conclusion is that a constraint for chest wall pain is yet to be defined. 相似文献23.
24.
Monika Scheer Christian Vokuhl Iris Veit‐Friedrich Marc Münter Thekla von Kalle Michael Greulich Steffan Loff Sabine Stegmaier Monika Sparber‐Sauer Felix Niggli Ruth Ladenstein Bernarda Kazanowska Gustaf Ljungman Kirsi Jahnukainen Jrg Fuchs Stefan S. Bielack Ewa Koscielniak Thomas Klingebiel 《Pediatric blood & cancer》2020,67(2)
25.
《Clinical neurophysiology》2021,132(12):3104-3115
ObjectiveWe aimed to establish an objective neurophysiological test protocol that can be used to assess the somatosensory nervous system.MethodsIn order to assess most fiber subtypes of the somatosensory nervous system, repetitive stimuli of seven different modalities (touch, vibration, pinprick, cold, contact heat, laser, and warmth) were synchronized with the electroencephalogram (EEG) and applied on the cheek and dorsum of the hand and dorsum of the foot in 21 healthy subjects and three polyneuropathy (PNP) patients. Latencies and amplitudes of the modalities were assessed and compared. Patients received quantitative sensory testing (QST) as reference.ResultsWe found reproducible evoked potentials recordings for touch, vibration, pinprick, contact-heat, and laser stimuli. The recording of warm-evoked potentials was challenging in young healthy subjects and not applicable in patients. Latencies were shortest within Aβ-fiber-mediated signals and longest within C-fibers. The test protocol detected function loss within the Aβ-fiber and Aδ-fiber-range in PNP patients. This function loss corresponded with QST findings.ConclusionIn this pilot study, we developed a neurophysiological test protocol that can specifically assess most of the somatosensory modalities. Despite technical challenges, initial patient data appear promising regarding a possible future clinical application.SignificanceEstablished and custom-made stimulators were combined to assess different fiber subtypes of the somatosensory nervous system using modality-specific evoked potentials. 相似文献
26.
《Clinical neurophysiology》2019,130(12):2231-2237
ObjectiveThe clinical and neurophysiological characteristics of myoclonus in Angelman syndrome (AS) have been evaluated in single case or small cohorts, with contrasting results. We evaluated the features of myoclonus in a wide cohort of AS patients.MethodsWe performed polygraphic EEG-EMG recording in 24 patients with genetically confirmed AS and myoclonus. Neurophysiological investigations included jerk-locked back-averaging (JLBA), cortico-muscular coherence (CMC) and generalised partial directed coherence (GPDC). CMC and GPDC analyses were compared to those obtained from 10 healthy controls (HC).ResultsTwenty-four patients (aged 3–35 years, median 20) were evaluated. Sequences of quasi-continuous rhythmic jerks mostly occurred at alpha frequency or just below (mean 8.4 ± 1.4 Hz), without EEG correlate. JLBA did not show any clear transient preceding the jerks. CMC showed bilateral over-threshold CMC in alpha band that was prominent on the contralateral hemisphere in the patient group as compared to HC group. GPDC showed a significantly higher alpha outflow from both hemispheres toward activated muscles in the patient group, and a significantly higher beta outflow from contralateral hemisphere in the HC group.ConclusionsThese neurophysiological findings suggest a subcortical generator of myoclonus in AS.SignificanceMyoclonus in AS has not a cortical origin as previously hypothesised. 相似文献
27.
目的探究创伤骨科护理管理中疼痛管理的应用价值。方法 82例患者选取于2017年6月-2018年6月,所有患者均来源于本院骨科收治的住院患者,数字表为患者分组原则,常规组41例,疼痛组41例,分别予以常规护理、常规护理+疼痛管理,比较满意度、疼痛评分及平均住院时间。结果疼痛组满意度92.68%比常规组73.17%高,差异具有统计学意义(χ^2=5.513,P <0.05),患者干预后的疼痛评分低于常规组,平均住院时间短于常规组,差异存在统计学意义(P<0.05)。结论疼痛管理用于创伤骨科护理管理中,患者疼痛明显减轻,患者满意度高,缩短了患者的平均住院时间。 相似文献
28.
2型糖尿病及骨质疏松已成为我国最主要的慢性代谢性疾病。2型糖尿病常伴有血脂紊乱,常表现为低密度脂蛋白升高,而越来越多的研究表明血脂通过不同的方式影响骨代谢,其机制可能是通过抑制骨髓间充质干细胞成骨分化,通过RANK/RNAKL/OPG信号通路及炎症反应调节破骨细胞等方式调节骨代谢。 相似文献
29.
《Seminars in Arthroplasty》2015,26(1):28-33
While use of large heads in total hip arthroplasty (THA) continues to grow, concerns have been raised regarding anterior hip pain resulting from impingement of the prosthetic head against soft-tissues like the iliopsoas. To address these concerns, a new anatomically contoured head (ACH) was developed. In this study cadaver tests were utilized to show that iliopsoas impingement/tenting caused by conventional heads is significantly relieved with the more rounded and reduced distal profile of the ACH. Thus, the ACH implant may be able to decrease the risk of soft-tissue impingement with conventional heads, particularly in the smaller hip. 相似文献
30.