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61.

Purpose

To evaluate the feasibility of a same-day yttrium-90 (90Y) radioembolization protocol with resin microspheres (including pretreatment angiography, lung shunt fraction [LSF] determination, and radioembolization) for the treatment of hepatocellular carcinoma (HCC) and liver metastases.

Materials and Methods

All same-day radioembolization procedures performed over 1 y (February 2017 to January 2018) were included in this single-institutional retrospective analysis, in which 34 procedures were performed in 26 patients (median age, 63 y; 13 women), 19 with liver metastases and 7 with HCC. Yttrium-90 treatment activities were calculated by body surface area method. Tumor imaging response was assessed by Response Evaluation Criteria In Solid Tumors (RECIST) 1.1 for liver metastases and modified RECIST for HCC. Clinical side effects and adverse events were graded per Common Terminology Criteria for Adverse Events version 4.0.

Results

All planned cases were technically successful, and no cases were canceled for elevated LSF or vascular anatomic reasons. Pretreatment angiography modified the planned 90Y treatment activity in 1 case in which vascular anatomy required a lobar-dose split into 2 for segmental infusions. In 18% of cases, patients were briefly admitted after the procedure for observation or symptom management. Imaging evaluation of initial efficacy at 1 month demonstrated partial response in 25% and stable disease in 67% of patients with liver metastases and partial/complete response in 43% and stable disease in 14% of patients with HCC. Grade ≥ 3 adverse events occurred in 6% of cases, with no systemic therapy–limiting toxicities. The mean total procedure time was 4.2 hours.

Conclusions

A same-day 90Y radioembolization protocol with resin microspheres is feasible in select patients, which can expedite cancer therapy.  相似文献   
62.
63.
ABSTRACT

Purpose

New instrument-based techniques for anterior chamber (AC) cell counting can offer automation and objectivity above clinician assessment. This review aims to identify such instruments and its correlation with clinician estimates.  相似文献   
64.
65.
梁畅  张伟 《现代肿瘤医学》2020,(11):1958-1962
我国乳腺癌的发病率占女性恶性肿瘤疾病的首位,结构扭曲病变(architectural distortion,AD)作为触诊阴性乳腺癌的第三最常见影像学表现,也是乳腺癌最早出现的征象,具有重要的临床价值。AD具有较高的漏诊率及假阳性率。本文通过查阅文献,针对超声、乳腺X线摄影、乳腺数字三维断层摄影技术及核磁共振成像技术在乳腺结构扭曲病变中的研究进展及优缺点进行分析,进一步指导科学研究及临床工作。  相似文献   
66.
目的探讨CT扫描在胸膜外孤立性纤维瘤(E-SFT)中的诊断价值。方法回顾性分析2015年4月至2018年4月于我院接受手术治疗的90例E-SFT患者术前CT检查影像资料和术后病理、免疫组织化学资料,评估CT检查在E-SFT诊断中的应用价值。结果 90例E-SFT患者均为单发肿瘤,免疫组织化学及病理学检查示良性80例,恶性10例;CT检查结果为良性72例,平扫表现为圆形或类圆形软组织密度影,密度不均匀,大部分边缘清晰,增强扫描表现为均匀强化;恶性18例,平扫示肿瘤体积较大,边界不清,密度不均,可见大片不规则低密度区,增强扫描瘤体强化不均匀,低密度区无明显强化;CT诊断的敏感度、准确度、特异性阳性率、阴性率分别为60%(6/10)、82%(74/90)、85%(68/80)、33%(6/18)、94%(68/72)。结论 E-SFT的CT检查影像图像具有一定的特征性,尤其是增强扫描有助于评估纤维瘤的良恶性,可将其作为术前诊断及术后复查评估的有效依据用于临床诊疗工作中。  相似文献   
67.
何敏  黄燕 《现代预防医学》2020,(23):4381-4384
目的 肺癌是全球发病率及死亡率最高的恶性肿瘤,患者5年生存率仍低于20%,提高早期诊断及筛查至关重要,本文对肺癌早期诊断方法进行文献综述。方法 检索PubMed、知网、万方、维普等数据库,选择与肺癌筛查相关的文献,进一步选择如CT、核磁共振、MiRNA、自身抗体等文献,提炼其相关结果结论。结果 肺癌早期诊断方法较多,每一种诊断方法均有其优缺点。结论 目前尚无任何一种技术被证实能独立完成早期肺癌的筛查,需要将目前早期诊断技术加以优化组合,以提高早期肺癌的诊断率。  相似文献   
68.
Background:Colon cancer is a common malignant tumor of the gastrointestinal tract. Therefore, a clear diagnosis is particularly important for the treatment of colon cancer. Ultrasound and spiral computed tomography (CT) can both be used in the diagnosis, but each has its own advantages and disadvantages, which could cause confusion in clinical choice. The purpose of this study was to systematically evaluate the practicability of spiral CT and ultrasound in the diagnosis of colon cancer.Methods:A systematic search was performed by retrieving on English databases (PubMed, Embase, Web of Science, the Cochrane Library) and Chinese databases (CNKI, Wanfang, Weipu [VIP], CBM). Besides, manually search for Google and Baidu academic of diagnostic experimental study of ultrasound and spiral CT in the diagnosis of Colon Cancer. The retrieval time limit was from the establishment of the database to October 2020. Two researchers independently extracted and evaluated the quality of the data in the included study. A meta-analysis was performed using Meta Disc1.4 and RevMan5.3 software.Results:Sensitivity, specificity, positive Likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were used to determine the diagnostic efficacy of ultrasonography and helical CT in colorectal cancer.Conclusions:This study will compare the practicability of CT and ultrasound in the diagnosis of colon cancer and provide reliable evidence-based basis for clinicians to choose the appropriate or best evidence-based basis.Ethics and dissemination:The private information from individuals will not be published. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences.OSF Registration number:DOI 10.17605/OSF.IO/WAJHQ  相似文献   
69.
We herein report a case of Klebsiella pneumoniae (K. pneumoniae) spondylitis and bacteremia in a 90-year-old man with diabetes mellitus who had undergone sigmoidectomy and had a fecalith. Two months prior to admission, he had received antimicrobial treatment for 2 weeks for K. pneumoniae bacteremia whose entry was unclear and he was readmitted to our hospital owing to fever and stomachache. K. pneumoniae was isolated from two sets of blood cultures, and computed tomography and magnetic resonance imaging revealed inflammation and destruction of the 8th and 9th thoracic vertebra. The diagnosis was spondylodiscitis secondary to K. pneumoniae bacteremia. Although the entry point for K. pneumoniae was unclear, we suggest that inflammation of the mucosa around the fecalith might have caused the Enterobacteriaceae bacteremia.  相似文献   
70.
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