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101.
MR imaging of locally advanced low rectal cancer: Relationships between imaging findings and the pathological tumor regression grade 下载免费PDF全文
102.
Association of ERG and TMPRSS2‐ERG with grade,stage, and prognosis of prostate cancer is dependent on their expression levels 下载免费PDF全文
103.
104.
Risk factors for seizures and antiepileptic drug‐associated adverse effects in high‐grade glioma patients: A multicentre,retrospective study in Hong Kong 下载免费PDF全文
105.
Kausik K Ray David A Morrow C Michael Gibson Sabina Murphy Elliott M Antman Eugene Braunwald 《European heart journal》2005,26(5):440-446
AIMS: Prior studies suggest that acute coronary syndromes (ACSs) are associated with endothelial activation and that this is of prognostic significance. We hypothesized that endothelial activation, as measured by a rise in von Willebrand Factor (DeltavWF), was influenced by the thrombolysis in myocardial infarction flow grade (TFG), the corrected TIMI frame count (CTFC) and the choice of anticoagulant therapy after fibrinolysis in ST elevation myocardial infarction (STEMI). METHODS AND RESULTS: Data were drawn from the enoxaparin and tenecteplase tissue plasminogen activator (TNK-tpa) with or without GPIIb/IIIa inhibitor as the reperfusion strategy in the STEMI trial (ENTIRE-TIMI 23). Three hundred and fourteen patients had serial measurements of vWF (baseline and 48-72 h) and angiographic data available. TFG<3 (P=0.0042) or CTFC>/=40 at 60 min (P=0.0035) were associated with a higher DeltavWF. DeltavWF >/=75th percentile was associated with a higher incidence of death or myocardial infarction (MI) at 30 days, compared with <75th percentile (11.2 vs. 4.1%, P=0.027). Enoxaparin independently reduced the DeltavWF (P=0.019) and also the composite of death or MI (OR 0.33, 95% CI 0.12-0.91, P=0.03) compared with unfractionated heparin. CONCLUSION: In STEMI treated by fibrinolysis, coronary flow at 60 min and choice of adjunctive anticoagulant appear to be independent determinants of DeltavWF. Enoxaparin is independently associated with a reduction in DeltavWF and a reduction in death or MI. The clinical benefits of enoxaparin as an adjunctive treatment in STEMI may be mediated in part by a reduction in vWF release. 相似文献
106.
目的探讨埃兹蛋白(Ezrin)在高分级前列腺上皮内瘤(HGPIN)及前列腺癌(CAP)中的表达及意义。方法采用免疫组化SP法检测44例CaP、12例HGPIN、20例前列腺增生(BPH)及10例正常前列腺(NP)组织中Ezrin的表达。结果31例(70.45%)CaP中Ezrin呈中等或强表达,12例HGPIN中Ezrin均呈弱或中等表达.20例BPH和10例NP中Ezrin没有或星弱表达。在CaP中。Gleason评分(GS)8~10分组的Ezrin表达明显高于7分组和5~6分组(P〈0.05),7分组Ezrin表达明显高于5~6分组(P〈0.05)。结论Ezrin的表达可能与CaP的发生有关,其对诊断HGPIN和判断CaP的转移及预后有重要意义。 相似文献
107.
Julia Tuchalska-Czuroń Jacek Lenart Justyna Augustyniak Marek Durlik 《Pancreatology》2019,19(1):73-79
Background
The aim of this prospective study was to investigate mitochondrial DNA (mtDNA) copy number in a group of resectable pancreatic cancer (PC) tumor tissues and adjacent normal pancreatic tissues, and to explore the correlation between the mtDNA content in tissues and the clinicopathological parameters and the overall survival.Methods
Relative mtDNA copy number was measured by the quantitative PCR-based assay. The tumors specimens (n?=?43) originated from the patients with pathologically confirmed pancreatic ductal adenocarcinoma who did not receive any neoadjuvant systemic therapy. The adjacent normal pancreatic tissue samples (n?=?31) were obtained from surgical margins.Results
mtDNA copy number was significantly lower in PC tissue (P?<?0.001) compared to adjacent normal pancreatic tissue. Jonckheere-Terpstra trend testing indicated a statistically significant decrease in median mtDNA copy number across the differentiation (adjacent normal pancreatic tissue, low-grade, intermediate-grade, high-grade cancer), P?<?0.001. However, the survival analyses failed to show a significant difference in survival between patients with high and low mtDNA copy number.Conclusions
To the best of our knowledge, we provided the first evidence that mitochondrial DNA copy number was significantly lower in pancreatic cancer tissue (P?<?0.001) compared to adjacent normal pancreatic tissue. Also, we demonstrated that mitochondrial copy number was not a significant marker for predicting prognosis in resectable pancreatic cancer. 相似文献108.
Relationship between mammaglobin expression and estrogen receptor status in breast tumors 总被引:3,自引:0,他引:3
Guan XF Hamedani MK Adeyinka A Walker C Kemp A Murphy LC Watson PH Leygue E 《Endocrine》2003,21(3):245-250
109.
Xiaolin Wang Yushan Liu Guangxin Cao Xueliang Zhang Haifei Xu Hanfeng Xu Jiandong Wang 《International journal of clinical and experimental pathology》2015,8(6):6821-6827
Aberrant expression of receptor tyrosine kinase EphA1 in malignant tissues has been reported. However, the expression profile of EphA1 in renal cell carcinoma (RCC) and its association with clinicopathological parameters remain unknown. The aim of this study was to determine the cancerous value of the EphA1 protein expression in patients with renal cell carcinomas. This study included 144 patients with clear cell RCC (ccRCC), 18 patients with chromophobe RCC and 6 patients with papillary RCC. The EphA1 protein was detected in RCC tissue samples by an immunohistochemical staining with a specific polycolonal antibody. The correlation of the expression of the EphA1 protein with clinicopathological parameters was evaluated. High level of the expression of EphA1 was observed in all normal renal tubes. The EphA1 protein was negatively or weakly expressed in 93 out of 144 ccRCC (64.6%) and positively expressed in 51 out of 144 ccRCC (35.4%). The high level expression of the EphA1 protein was significantly associated with younger patients (P<0.001), sex (P=0.016) and lower nuclear grade (P<0.001). No significant relation between the expression of EphA1 and tumor diameter was found (P=0.316). Positive expression of EphA1 was observed in all samples of chromophobe RCC and papillary RCC. Our data indicated that the EphA1 protein may be a new marker for the prognosis of ccRCC. 相似文献
110.
Shogo Tajima Kenji Koda 《International journal of clinical and experimental pathology》2015,8(5):5113-5120
Development of malignant peripheral nerve sheath tumors (MPNSTs) is a stepwise process that involves the alteration of many cell cycle regulators and the double inactivation of the NF1 gene. Inactivation of the TP53 gene and deletion of the CDKN2A/p16 gene are known to play an important role in the process. Herein, we present a 19-year-old man with a familial history of neurofibromatosis type 1, in whom the tumor arose from the intercostal nerve and showed 3 components: a neurofibroma, a low-grade MPNST, and a high-grade MPNST. Loss of p16 expression and homozygous deletion of the CDKN2A/p16 gene were observed in both the low-grade and the high-grade MPNST. In contrast to low-grade MPNSTs, high-grade MPNSTs generally tend to lose expression of p16 and harbor homozygous deletion of the CDKN2A/p16 gene. Loss of p16 expression and homozygous deletion of the CDKN2A/p16 gene in low-grade MPNST in our case might be related to its progression to high-grade MPNST. To the best of our knowledge, this is the first study correlating the p16 expression status and CDKN2A/p16 gene alteration in low-grade MPNSTs. 相似文献