细胞间黏附分子1和血管细胞黏附分子1在血管瘤组织中表达的意义

目的：探讨细胞间黏附分子1（ICAM-1）和血管细胞黏附分子1（VCAM-1）在小儿血管瘤增殖退化病理生理演变过程中的表达及作用机制.方法：应用SABC免疫组化法检测28例增殖期血管瘤及22例退化期血管瘤的ICAM-1、VCAM-1在血管内皮细胞上的表达情况,同时以血管畸形及正常皮肤为对照.结果：ICAM-1在增殖期血管瘤强阳性表达,退化期阳性表达,两时期差异十分显著（P＜0.01）;VCAM-1在增殖期和退化期血管瘤均为阳性表达,两时期无明显差异;ICAM-1和VCAM-1在血管畸形和正常皮肤几乎均为阴性表达,与不同时期血管瘤相比差异均十分显著（P＜0.01）.结论：ICAM-1可能在血管形成早期发挥作用,介导内皮细胞间黏附,参与血管瘤发病和消退的病理过程.     

康柏西普联合玻璃体切割术治疗视网膜血管瘤引起的 视网膜脱离的疗效观察

目的 回顾性分析视网膜毛细血管瘤(RCH)引起的视网膜脱离患者行单纯玻璃体切割手术或玻璃体腔注射康柏西普联合玻璃体切割手术的治疗效果。 方法 采用23 G玻璃体切割术和激光凝固和(或)冷冻疗法治疗15例(15眼)由RCH引起的视网膜脱离患者,其中6例(6眼)玻璃体腔内注射康柏西普7 d后行玻璃体切割术(注射组),9例(9眼)单纯行玻璃体切割术(未注射组)。记录手术时间、最佳矫正视力(BCVA)、眼底情况、荧光素血管造影(FFA)结果以及全身情况,并进行比较分析。 结果 未注射组中,7眼视网膜平复、肿瘤消退,1眼出现新的RCH,1眼复发视网膜脱离。注射组中,5眼术后视网膜平复、肿瘤消退,1眼复发视网膜脱离。 结论 23 G玻璃体切割联合玻璃体腔注射康柏西普,对RCH引起的严重的出血性视网膜脱离有较好的疗效,可明显减少手术时间及术中出血,减少手术次数。根据FFA的结果行激光光凝和(或)冷冻治疗是治疗成功的重要因素。     

基于HMGB1探讨“易层”贴敷对KOA大鼠滑膜纤维化的影响

目的 基于HMGB1研究“易层”贴敷对膝骨关节炎（KOA）大鼠滑膜纤维化的影响。方法 30只SPF级SD大鼠,随机均分为空白对照组、模型组及易层组。KOA模型通过碘乙酸钠构建,造模成功后,易层组外敷“易层”贴敷28 d。末次给药后腹主动脉采血并提取各组滑膜组织,HE染色观察滑膜炎症;ELISA检测血清中促炎因子IL-1β、IL-6、TNF-α,抑炎因子IL-4、IL-10、TGF-β含量;Western blot和qPCR检测滑膜HMGB1及α-SMA、TIMP1、CollagenⅠ、CollagenⅢ蛋白和基因表达量。结果 HE染色显示易层组炎性细胞浸润较模型组显著减少,排列较为规则;模型组较空白对照组IL-1β、IL-6、TNF-α含量明显升高（P<0.05）,易层组较模型组IL-1β、TNF-α含量明显降低（P<0.05）,模型组较空白对照组IL-4含量明显升高（P<0.05）,IL-10、TGF-β含量明显降低（P<0.05）,易层组较模型组IL-10含量明显升高（P<0.05）;HMGB1及α-SMA、TIMP1、CollagenⅠ、CollagenⅢ的蛋白和基因水平在模型组较空白对照组表达增加（P<0.05）,易层组较模型组表达下调（P<0.05）。结论 “易层”贴敷能够抑制滑膜纤维化,其作用机制可能与抑制HMGB1、平衡促炎因子和抑炎因子有关。      

Characterization of long‐term outcomes for pediatric patients with epithelioid hemangioma

Epithelioid hemangioma (EH) is a rare benign vascular tumor that occurs in soft tissues and bone and presents between the third and sixth decades of life. Little is known about the clinical course and outcomes of pediatric EH. We report 11 patients diagnosed with EH at a median age of 14.4 years. One patient treated with interferon and one with sirolimus exhibited partial response for >2 years. Although a benign neoplasm, EH is difficult to manage without standard protocols and portends considerable morbidity. Our findings suggest medical management, particularly sirolimus, may benefit these patients; however, long‐term follow‐up is needed.     

A case report of primary cardiac capillary hemangioma

Background: Hemangioma of the heart, presenting as a primary cardiac tumor is extremely rare. Methods: We present a 20-year-old male with a cardiac tumor which was incidentally discovered during routine clinical examination. Results: Echocardiography showed a large intramyocardial mass attached to the left ventricle, close to the apex. A tumor was shown near the apex of the left ventricle by Cardiac CT. We performed a total resection surgery of the tumor one week after admission and the patient recovered well and discharged from hospital 7 d after surgery. Conclusion: The pathological diagnosis was primary cardiac capillary hemangioma. No tumor recurrence was shown by echocardiography after 20 months follow-up visits.     

Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically

This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, pseudolymphomatous angiosarcoma, lymphadenoid dermatofibroma, lymphomatoid atypical fibroxanthoma, histiocytoid (epithelioid) hemangioma, and inflamed melanocytic lesions. The clinical and pathological features of those tumors are considered.     

Couverture d’une perte de substance palmaire par un lambeau synovial des fléchisseurs superficiels des doigts

Post-traumatic palmar soft tissue defects are a difficult problem in plastic surgery and many techniques have been described. We report the case of a 41-year-old patient with a large palmar soft tissue defect of the right hand due to a work accident. The classical flaps used in this indication were not usable. So, we chose the synovial flap of the Flexor digitorum superficialis to cover this palmar defect. We discuss the coverage possibilities for a hand palmar defect in emergency, and the use of the synovial flap in this indication. This case report shows that the synovial flap could be an option for the coverage of palmar soft tissue defects.     

Pro-apoptotic effect of nonsteroidal anti-inflammatory drugs on synovial fibroblasts

Abstract

Rheumatoid arthritis (RA) is a systemic inflammatory disease that mainly affects the articular synovial tissues. Although the etiology of RA has not yet been elucidated, physical and biochemical inhibition of synovial hyperplasia, which is the origin of articular destruction, may be an effective treatment for RA. Nonsteroidal anti-inflammatory drugs (NSAIDs) have long been used for the treatment of RA. The mechanism of action of NSAIDs generally involves the inhibition of cyclooxygenase (COX) at sites of inflammation. Thus, NSAIDs were not generally considered to have a so-called anti-rheumatic effect, including inhibition of progressive joint destruction and induction of remission. However, certain conventional NSAIDs and celecoxib, a selective COX-2 inhibitor, have been reported to inhibit synovial hyperplasia by inducing the apoptosis of human synovial fibroblasts. Therefore, it has been suggested that such NSAIDs may not only have an anti-inflammatory effect but also an anti-rheumatic effect. In this review, we summarize findings about the pro-apoptotic effect, in other words, anti-proliferative effect of NSAIDs on synovial fibroblasts from patients with RA.     

平阳霉素局部注射治疗小儿皮肤血管瘤疗效评价

目的:评价平阳霉素局部注射治疗小儿皮肤血管瘤的临床疗效。方法:根据患儿年龄、病变部位、皮损大小等,使用不同剂量的平阳霉素治疗草莓状血管瘤、海绵状血管瘤和混合性血管瘤126例。结果:经过3年的随访,总有效率75.6%。结论:平阳霉素局部注射治疗小儿皮肤草莓状血管瘤、海绵状血管瘤和混合性血管瘤有效。