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991.
妇科腹腔镜手术几种激光对兔子宫壁损伤的实验研究 总被引:2,自引:2,他引:0
为掌握妇科腹腔镜手术所应用的激光器的治疗剂量,对几种激光引起的兔子宫壁热损伤进行观察。实验研究证实:所有激光产生的损伤程度与所用的剂量呈正相关。术后48h与即刻损伤程度相比,半导体激光的损伤程度明显加深、加宽;但CO2激光和NdYAG激光接触式光刀无显著变化。说明应用激光行妇科腹腔镜手术治疗时,所产生的损伤与应用的功率密度有关,为临床合理选用腹腔镜下的激光治疗提供依据 相似文献
992.
大鼠脊髓缺血再灌流时脊髓神经元对躯体和内脏传入刺激的反应 总被引:1,自引:0,他引:1
50只大鼠用乌拉坦麻醉,箭毒制动。通过阻断腹主动脉血流以模拟腰段脊髓的局部缺血和再灌流损伤,玻璃微电极记录L2节段脊髓单位放电(SCUDs),观察缺血再灌流时脊髓神经元对腓神经刺激(PNV),内脏大神经刺激(VLNV)及两者同时刺激(SV)的反应。结果在缺血前所记录的133个自发放电单位中,对3种刺激均产生兴奋(E)、抑制(I)及无反应(NR)3种形式的反应,表明大鼠L2节段脊髓存在躯体、内脏和躯体内脏反应性神经元,并有会聚和阻塞现象。在脊髓缺血再灌流时,神经元对PNV、VLNV、SV也产生E、I、NR3种形式的反应,提示脊髓缺血再灌流时神经元对躯体和内脏传入刺激的反应形式不受影响;但缺血时SCUDs对PNV、VLNV产生反应的单位数减少,这表明脊髓缺血损伤时神经元对躯体和内脏传入刺激的反应性减弱,随着缺血损伤加重,脊髓神经元对躯体内脏信号的整合功能下降 相似文献
993.
Bruce Becker MD Robert Woolard MD Ted D. Nirenberg PhD P. Allison Minugh PhD Richard Longabaugh EdD Patrick R. Clifford PhD 《Academic emergency medicine》1995,2(9):784-790
Objectives: To determine the incidence of alcohol use in subcritically injured patients presenting to the ED, by using a saliva alcohol test (SAT) at ED triage during the ED initial assessment; to compare the incidence of alcohol use revealed by the SAT with documentation of alcohol use by ED nurses and emergency physicians (EPs) blinded to the SAT results; and to describe the demographics of the SAT-positive, subcritically injured population.
Methods: A blinded, prospective, observational evaluation of ED patients presenting with subcritical injuries was performed. The patients were tested for alcohol use with an SAT, and a subsequent record review was conducted for extraction of demographic data and evidence of documentation of alcohol use by ED nurses and EPs blinded to the SAT results.
Results: During the study. 791 subcritically injured patients had SATs performed. Twenty-one percent of these patients were found to be alcohol-positive by SAT. Either the ED nurse or the EP documented a clinical impression of alcohol use for 52% of the SAT-positive patients. There were higher SAT-positive rates among men (24%), victims of assault (47%), and patients arriving at night (41%).
Conclusions: While the SAT identified 21% of the subcritically injured patient population as alcohol-positive, ED nurse and EP documentation did not identify half of these alcohol-positive patients. Many of these patients may be at risk for additional injuries related to their drinking behavior. 相似文献
Methods: A blinded, prospective, observational evaluation of ED patients presenting with subcritical injuries was performed. The patients were tested for alcohol use with an SAT, and a subsequent record review was conducted for extraction of demographic data and evidence of documentation of alcohol use by ED nurses and EPs blinded to the SAT results.
Results: During the study. 791 subcritically injured patients had SATs performed. Twenty-one percent of these patients were found to be alcohol-positive by SAT. Either the ED nurse or the EP documented a clinical impression of alcohol use for 52% of the SAT-positive patients. There were higher SAT-positive rates among men (24%), victims of assault (47%), and patients arriving at night (41%).
Conclusions: While the SAT identified 21% of the subcritically injured patient population as alcohol-positive, ED nurse and EP documentation did not identify half of these alcohol-positive patients. Many of these patients may be at risk for additional injuries related to their drinking behavior. 相似文献
994.
The effects of two H2-receptor antagonists, famotidine and cimetidine, on the plasma levels of epidurally administered lignocaine were studied. Group A (n = 20) received famotidine 20 mg orally the night before surgery and 20 mg intramuscularly 60 minutes before induction of anaesthesia. Group B (n = 15) received cimetidine 200 mg orally the night before the surgery and 400 mg orally 60 minutes before the anaesthetic induction. Group C (n = 20) received neither famotidine nor cimetidine and served as controls. Twelve millilitres of 2.0% lignocaine with adrenaline 1:200,000 was injected into the epidural space in all patients, after the establishment of general anaesthesia with nitrous oxide, oxygen, and enflurane (0.3-0.5%). The patients who received cimetidine showed significantly higher plasma concentrations of lignocaine compared with either group A or group C at all investigation times (p less than 0.01). The mean peak plasma concentrations were 2.4 (SEM 0.1), 3.2 (SEM 0.2) and 2.3 (SEM 0.1) micrograms/ml in group A, B, and C, respectively. This study suggests that famotidine is preferable to cimetidine for control of gastric acidity before the use of lignocaine as the epidural anaesthetic. 相似文献
995.
胃癌组织内微血管定量的意义 总被引:2,自引:0,他引:2
目的:研究胃癌组织中微血管数量(MVC)与临床病理因素及预后的关系。方法:材料取自瑞金医院1988年~1991年胃癌手术切除标本,共128例。抗因子Ⅷ相关抗原(F-ⅧRAg)的单克隆抗体和免疫组化试剂盒购自Dako公司。研究方法按LSAB法免疫组织化学操作技术常规进行;微血管定量以镜下200倍,肿瘤内5个最高微血管密度区的MVC均数表示;分析MVC与临床病理因素之间关系,并对有完整5年随访资料的86例胃癌患者预后与MVC关系进行探讨。结果:所有胃癌组织中的平均MVC为16.5±8.5,MVC随TNM分期增加而增加,有淋巴结转移患者的MVC(18.3±8.7)明显高于无淋巴结转移患者(13.8±7.4)(P<0.01),高MVC(≥16)胃癌患者比低MVC(<16)患者预后明显为差,5年生存率分别为42.5%和58.7%(P<0.05)。结论:MVC在胃癌患者是一个有意义的预后指标. 相似文献
996.
Hyperaemia prior to acute cerebral swelling in severe head injuries: The role of transcranial doppler monitoring 总被引:4,自引:0,他引:4
Z. Muttaqin M.D. T. Uozumi S. Kuwabara K. Arita K. Kurisu S. Ohba H. Kohno H. Ogasawara M. Ohtani T. Mikami 《Acta neurochirurgica》1993,123(1-2):76-81
Summary Acute cerebrovascular congestion after a closed head injury is significantly related to intracranial hypertension. As an indirect method of cerebral blood flow measurement, transcranial doppler sonography (TCD) provides a rapid and noninvasive assessment of cerebral haemodynamics, including hyperaemic conditions.TCD examinations was serially performed in 35 patients with severe head injury with intact cerebral circulation; i.e. the mean flow velocity (MFV) patterns of the middle cerebral artery (MCA) did not show signs of cerebral circulatory arrest such as systolic spike, to and fro, or no flow. The results showed that the MFV of the MCAs and ipsilateral extracranial internal carotid arteries (ICAs) in 9 of these patients increased sharply and pulsatility index (PI) decreased during 48–96 hours after the injury. This was soon followed by patterns of high intracranial resistance, consistent with elevated intracranial pressure (ICP) in monitored patients and acute brain swelling on repeated computed tomographic (CT) scans. The correlation between increased MFVs, decreased PIs, and cerebral haemodynamic changes leading to acute brain swelling is discussed.The number of patients who ended with severe disability, vegetative state, or death was 66% in this group of 9 patients, compared to only 34% for the 35 patients overall with severe head injury. Though the morbidity and mortality rates largely depend on the primary injury, the presence of acute cerebral swelling aggravate the grave course in these patients. And the ability of TCD to monitor the hyperaemic state prior to oedema should lead us to adjust the therapy in order to minimize the secondary insult related to intracranial hypertension. 相似文献
997.
应用神经组织化学技术观察了兔角膜NA能神经及AchE阳性神经在角膜损伤后的再生,证实术后1月,两种神经均有再生轴突进入植片;术后3月可见交界区和植床内神经密度明显增加;同时,对术后两种神经再生的功能意义进行了讨论。 相似文献
998.
999.
John N. K. Hsiang Keith Y. C. Goh Xian-Lun Zhu Wai S. Poon 《Child's nervous system》1996,12(10):611-614
Head injury in children causes special concern in most communities. From 1989 to 1994, 2,785 children younger than 16 years old were admitted to our neurosurgical service because of head injury. Fall from a height was the major cause of head injury leading to admission in infants and children in preschool age groups, whereas traffic-related or bicycle-related accidents were more likely to be the cause of head injury for those aged 11–15 years. In all age groups there was a male preponderance. The overall mortality was 0.6%. Traffic-ralated accidents caused more severe injury and accounted for 67% of all fatalities. For patients under 6 years old, about 40% of head injuries occurred at home. Preventive measures for pediatric head injury in Hong Kong are suggested. 相似文献
1000.
Minerva Giménez y Ribotta Christelle Roudet Françoise Sandillon Alain Privat 《Brain research》1996,707(2):245
The synaptic connections established by grafted noradrenergic (NA) neurons into the lesioned adult rat spinal cord were analysed using immunocytochemistry at the electron microscopic level. An embryonic cell suspension of the locus coeruleus region from E-13 rat embryos was transplanted into the spinal cord following either: (1) spinal cord transection or (2), partial selective denervation by 6-hydroxy dopamine (6-OH DA). One month after grafting, the NA-neurons established, in the two models, an innervation pattern similar to that found in the intact spinal cord. In both models, the transplanted NA-immunoreactive neurons formed extensive synaptic contacts with dendrites, spines and perikarya. The proportion of axodendritic and axospinous contacts was inverse in the two models. The first model thus reproduced more closely the normal synaptic pattern prefering dendritic targets, which could correspond to a better integration of the graft. In the second model, a partially NA-denervated spinal cord, there existed a competition between residual intrinsic and grafted neuron-derived fibres, which presumably affects synaptogenesis. In conclusion, the present study illustrate the complexity of cell interations conducting to the formation of a specific circuitry. Recognition phenomenon are likely modulated by space constraints, which ultimately shape-up the geometry of synaptic contacts. 相似文献