上矢状窦旁中后1/3脑膜瘤术中回流静脉的保护研究

目的探讨上矢状窦中后1/3脑膜瘤术中保护回流静脉的方法及意义,为确保手术成功提供参考依据。方法回顾性分析本院神经外科2011年8月至2013年8月收治的50例上矢状窦旁中后1/3脑膜瘤患者的临床资料,按照是否保护回流静脉分为观察组(36例)和对照组(14例)。观察组患者行静脉磁共振血管成像(MRV)检查,明确上矢状窦通畅程度与脑膜瘤周边静脉回流代偿情况,术中尽量保护回流静脉及正常脑组织,妥善处理受累矢状窦。对照组患者采用传统手术方式治疗,未评价矢状窦通畅情况,未保护回流静脉。依据Simpson标准评价肿瘤切除程度,比较两组患者肿瘤全切率、死亡率、对症治疗及随访情况。结果两组患者均顺利完成手术,观察组患者肿瘤全切除34例(94.44%),对照组患者肿瘤全切除10例(71.43%),两组均未出现死亡病例,观察组患者手术效果明显优于对照组,差异具有显著性(P<0.05)。结论上矢状窦中后1/3脑膜瘤术前行MRV检查,术中保护回流静脉可提高肿瘤全切除率,改善患者的生存质量。     

Current evidence on where to end a fusion within the thoracolumbar junction most preferably – A systematic literature review

Proximal junctional kyphosis (PJK) is one main complication in the surgical treatment of adult spinal deformities. Ending within the thoracolumbar junction (TLJ) should but cannot always be avoided to reduce the risk for PJK. With this systematic review we sought to define the most preferable vertebra within the TLJ to minimize the risk for PJK and establish recommendations based on our findings. We conducted a systematic literature review by scanning the MEDLINE database in accordance with the PRISMA criteria. All articles addressing primary long-distance dorsal thoracolumbar fusion of at least three segments to treat adult spinal deformities were included. 1385 articles were identified and three were included to this review. The first study showed significantly higher rates of PJK in patients where the construct was extended to T7 or higher when compared to an ending at T11 to L1. The second article stated that an expansion to the TLJ resulted in significantly less surgical revisions due to PJK reduction. On the other hand, the third article found that a fusion of the whole thoracic spine reduces the PJK incidence postoperatively. Even though the most favorable vertebra within the TLJ to avoid PJK best could not yet be determined, our study identifies several principles that represent the current state of evidence for surgical treatment of adult scoliosis. Proper preoperative decision making based on thorough analysis and interpretation of the patient's sagittal alignment parameters can improve the individual outcome critically.     

The relationship between cervical lordosis and Nurick scores in patients undergoing circumferential vs. posterior alone cervical decompression,instrumentation and fusion for treatment of cervical spondylotic myelopathy

The loss of regional cervical sagittal alignment and the progressive development of cervical kyphosis is a factor in the advancement of myelopathy. Adequate decompression of the spinal canal along with reestablishment of cervical lordosis are desired objective with regard to the surgical treatment of patients with cervical spondylotic myelopathy. A retrospective chart review was conducted in which patients who underwent either a combined anterior/posterior instrumentation and decompression or a posterior alone instrumentation and decompression for the treatment of CSM at our institution were identified. Any patient undergoing operative intervention for trauma, infection or tumors were excluded. Similarly, patients undergoing posterior instrumentation with constructs extending beyond the level of C2–C7 were similarly excluded from this study. A total of 67 patients met the inclusion criteria for this study. A total of 32 patients underwent posterior alone surgery and the remaining 35 underwent combined anterior/posterior procedure. Radiographic evaluation of patient’s preoperative and postoperative cervical lordosis as measured by the C2–C7 Cobb angle was performed. Each patient’s preoperative and postoperative functional disability as enumerated by the Nurick score was also recorded. Statistical analysis was conducted to determine if there was a significant relationship between improvement in cervical lordosis and improvement in patient’s clinical outcomes as enumerated by the Nurick Score in patients undergoing posterior alone versus combined anterior/posterior decompression, instrumentation and fusion of the cervical spine.     

可逆性上矢状窦血栓大鼠模型的建立

目的建立可逆性上矢状窦血栓（SSST）大鼠模型，观察模型的稳定性和成功率。方法取雄性SD大鼠90只，随机分为模型组和对照组，每组45只；模型组采用上矢状窦局部置管并注射活化部分凝血活酶试剂建立大鼠SSST模型；对照组采用上矢状窦三氯化铁滤纸贴敷法建立SSST模型。两组于手术后24h行MRI及MR静脉造影（MRV），确定造模是否成功。模型成功后，分别于1、2、3、4周行MRI、MRV，观察上矢状窦再通情况及脑组织改变；取大鼠上矢状窦顶叶皮质脑组织标本行病理学观察。结果模型组模型成功41只，成功率为91％；总再通率为10％；对照组模型成功34只，成功率为75％，总再通率为45％。两组比较差异有统计学意义，P〈0．05。模型组大鼠脑组织水肿及梗死较对照组明显，而内皮细胞损伤较对照组轻微。结论改良法建立的大鼠可逆性上矢状窦血栓模型成功率高、稳定和重复性好。     

Association of diet quality,physical activity,and abdominal obesity with metabolic syndrome z-score in black and white adolescents in the US

Background and aimsMetabolic syndrome (MetS) affects ～10% of adolescents and is associated with cardiometabolic disease risk. The most prevalent MetS component is abdominal obesity. Healthy diet and physical activity (PA) are inversely associated with abdominal obesity and may reduce MetS risk in youth. Our aim was to examine associations of diet, activity, and abdominal obesity with MetS z-score (MetS-z).Methods and resultsAn analysis of National Health and Nutrition Examination Survey (NHANES) 2011–2016 data in adolescents was performed. Healthy Eating Index (HEI)- 2015 scores were calculated for diet quality, PA habits were used to determine alignment with national guidelines, and abdominal obesity was assessed by sagittal abdominal diameter (SAD). MetS-z represented severity or potential risk for MetS. Multivariable regression evaluated the relationships of HEI, SAD and PA with MetS-z. Among 1214 black and white adolescents, SAD was significantly associated with MetS-z [β (95% CI) = 0.17 (0.16, 0.19); P <0.0001] while HEI-2015 components showed associations with MetS-z overall (HEI total, dairy, and sodium scores), and by sex (total, refined grains, dairy for males; added sugar, protein, whole grains for females). Mean HEI-2015 score was 47.4/100 (51.6 using the population-ratio method), and the proportion of adolescents meeting national PA guidelines was 37.6%, yet PA was not a significant predictor of MetS-z.ConclusionsUS adolescents have poor diet quality and fewer than half meet PA guidelines. Strategies for preventing MetS and related conditions in adolescence should focus on weight management – specifically, abdominal fat reduction – with individualized diet counseling.     

Transient structural MRI patterns correlate with the motor functions in preterm infants

AimTo explore the relationships between transient structural brain patterns on MRI at preterm and at term-equivalent age (TEA) as a predictor of general movements (GMs) and motor development at 1-year corrected age (CA) in very preterm infants.MethodsIn this prospective study, 30 very preterm infants (median = 28wks; 16 males) had structural magnetic resonance imaging (MRI) at preterm (median = 31wks + 6d) and at TEA (median = 40wks) and neuromotor assessments. The quality of GMs was assessed by Prechtl’s general movements assessment and a detailed analysis of the motor repertoire was performed by calculating a motor optimality score (MOS), both at term age and at 3 months post-term. Motor development at 1-year CA was evaluated with the Infant Motor Profile (IMP). Associations between qualitative MRI findings and neuromotor scores were investigated.ResultsAbnormal GMs and low motor performance at 1-year CA were associated with the poor visibility of transient structural pattern, that is with sagittal strata.InterpretationTransient structural MRI pattern, sagittal strata, at preterm age is related to the quality of GMs and later motor development in preterm infants. This transient fetal brain compartment may be considered as a component of neurobiological basis for early neuromotor behavior, as expressed by GMs.     

Evaluation of border movement of the mandible before and after orthognathic surgery using a kinesiograph

PurposeThe purpose of this study was to examine the changes in the mandibular border movement between class II and class III jaw deformity patients before and after orthognathic surgery, by using the same device.Subjectsand Methods: Eighty one patients (28 in class II and 53 in class III) who underwent sagittal split ramus osteotomy (SSRO) with Le Fort I osteotomy using absorbable plate fixation and 27 controls with normal occlusion were enrolled. Mandibular border movement (observed using a kinesiograph) was recorded with a mandibular movement measure system (K7) before surgery, and at 6 months and 1 year after surgery. Time-course changes of 5 components of the mandibular border movement (MVO: Maximum vertical opening, CO to MAP: Maximum antero-posterior movement from centric occlusion, MLDL: maximum lateral deviation left, MLDR: maximum lateral deviation right, CO to MO: centric occlusion to maximum opening) were compared between classes II, III and controls statistically. The relationship between lateral cephalometric measurements and the components of mandibular border movement was also examined.ResultsThere was a significant difference in CO to MAP (P = 0.0025) and CO to MO (P < 0.0001) between class II and class III in the time-course change.In class III, mean and standard deviation of MVO were 44.5 ± 6.7 mm before surgery and 39.8 ± 6.8 mm after 1 year. Mean and standard deviation of CO to MAP were 25.2 ± 6.8 mm before surgery and 21.5 ± 7.9 mm after 1 year. Mean and standard deviation of CO to MO were 53.4 ± 9.0 mm before surgery and 47.3 ± 8.4 mm after 1 year.In class II, mean and standard deviation of MVO were 38.8 ± 5.8 mm before surgery and 36.2 ± 7.4 mm after 1 year. Mean and standard deviation of CO to MAP were 18.0 ± 6.3 mm before surgery and 17.8 ± 7.4 mm after 1 year. Mean and standard deviation of CO to MO were 43.1 ± 7.5 mm before surgery and 39.6 ± 10.5 mm after 1 year.In MVO, CO to MAP and CO to MO, the values after 1 year did not significantly reach the pre-operative values in class III (P = 0.0001, P = 0.0007 and P < 0.0001), although there was no significant difference between pre-operation and after 1 year in class II.In CO to MO, class II (mean and standard deviation 39.6 ± 10.5 mm) and class III (mean and standard deviation 47.3 ± 8.4 mm) still remained smaller values than control (mean and standard deviation 52.7 ± 9.2 mm) after 1 year (P < 0.0001 and P = 0.0095).ConclusionThis study suggests that bi-maxillary surgery can have more influence on the reduction in the range of mandibular border movement including vertical or antero-posterior motion than lateral deviation motion, in both groups. The difference in the time-course change in the mandibular border movement between the groups might depend more on the mandibular length than on the movement direction of the mandible by surgery such as advancement or setback.     

What factors affect the attachment of the inferior alveolar nerve to the buccal plate following sagittal split osteotomy?

PurposeThis study aimed to assess the factors that can possibly affect the positioning of the inferior alveolar nerve (IAN) in the proximal or distal segment following sagittal split osteotomy (SSO).Materials and methodsThis was a prospective cohort study. The patients were assigned according to the position of the IAN: the IAN was attached to the buccal plate in group 1 (27 SSOs), while it was in the distal segment in group 2 (83 SSOs).ResultsThe mean of the buccolingual thickness of the proximal segment at the vertical cut of the osteotomy (BLTP) was 5.0 ± 0.62 mm in group 1 and 4.16 ± 0.72 mm in group 2. The mean of the distance between the IAN and the external cortical bone at the distal of the second molar before the osteotomy (IANB) was 0.5 ± 0.24 mm in group 1 and 1.24 ± 0.45 mm in group 2. There were significant differences for the mean BLTP and IANB between the two groups (P = 0.001).ConclusionIt seems that the thickness of the buccal plate of the proximal segment, the distance from the IAN to the external cortical bone, the osteotomy technique, and the presence or absence of impacted third molars may be associated with the positioning of the IAN following SSO.