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91.
目的 观察重组人白细胞介素-4(rhIL-4)对银屑病样小鼠模型的影响.方法 采用小鼠雌激素期阴道上皮和鼠尾鳞片表皮实验模型,不同组别的小鼠给以甲氨喋呤或不同剂量的rhIL-4,分别观察其对增生阴道上皮细胞有丝分裂和鼠尾鳞片颗粒层形成的影响.结果 rhIL-4的3个剂量组均可抑制小鼠阴道上皮的有丝分裂,促进鼠尾鳞片颗粒层形成.结论 提示rhIL-4具有促进银屑病样小鼠模型恢复的作用. 相似文献
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94.
Examples of Acupuncture Treatment for Intractable Diseases 总被引:1,自引:0,他引:1
孙吉山 《针灸推拿医学(英文版)》2008,6(6):324-327
1 Spermatorrhea
A patient, 16 years old, suffered from spermatorrhea for over one year. At the beginning, it happened once several days, and recently it happened once every other day or every night, accompanied by a withered complexion, soreness and weakness in the lower back and legs, poor sleep, poor memory, a red tongue tip with thin tongue coating, and a thready and rapid pulse. The condition is attributed to kidney deficiency leading to poor containing ability, seminal emissions, and intemal disturbance of monarch fire. Therefore, bilateral Tongli (HT 5), Shenshu (BL 23), Guanyuan (CV 4) and Taixi (KI 3) were punctured by the twisting technique for reinforcement, 相似文献
A patient, 16 years old, suffered from spermatorrhea for over one year. At the beginning, it happened once several days, and recently it happened once every other day or every night, accompanied by a withered complexion, soreness and weakness in the lower back and legs, poor sleep, poor memory, a red tongue tip with thin tongue coating, and a thready and rapid pulse. The condition is attributed to kidney deficiency leading to poor containing ability, seminal emissions, and intemal disturbance of monarch fire. Therefore, bilateral Tongli (HT 5), Shenshu (BL 23), Guanyuan (CV 4) and Taixi (KI 3) were punctured by the twisting technique for reinforcement, 相似文献
95.
The purpose of this study was to evaluate the serum levels of hyaluronic acid (HA) in a group of patients with psoriatic
arthritis (PsA), with special emphasis on the relationships between HA levels and clinical parameters of joint and skin activity.
Thirty-four patients with PsA, 34 patients with rheumatoid arthritis (RA) and 49 healthy volunteers participated in the study.
Assessment of joint disease in patients with PsA included duration of morning stiffness, number of tender and swollen joints,
right and left grip, the presence of inflammatory back pain and Schober’s test. The current severity of skin involvement was
graded according to the Psoriasis Area Severity Index (PASI). Serum levels of HA were measured by a radiometric assay. The
mean HA serum levels of patients with PsA and RA were significantly increased in comparison with healthy controls (107 ± 39.6
μg/dl in patients with PsA, whereas in patients with RA it was 168 ± 32.4 μg/dl and 36.7 ± 5.5 μg/dl in healthy controls).
A highly significant correlation was found between levels of HA and index of skin involvement, but no association was found
between HA levels and clinical parameters of joint severity. We conclude that in this cohort of patients with PsA, HA levels
clearly reflected psoriatic skin involvement although it did not correlate with joint disease.
Received: 18 June 1999 / Accepted: 5 April 2000 相似文献
96.
目的:检测寻常型银屑病患者血清白细胞介素-18(IL-18)和干扰素诱导蛋白-10(IP-10),探讨其在银屑病发生、发展过程中的作用。方法:采用竞争酶联免疫吸附(ELISA)法对30例寻常型银屑病患者(其中进行期16例,静止期14例)血清中的IL-18和IP-10水平进行检测。结果:正常对照组血清IL-18和IP-10水平分别为(158.38±13.64)ng/L和(148.73±11.44)ng/L;银屑病患者静止期组血清IL-18和IP-10水平分别为(350.07±19.74)ng/L和(345.62±8.75)ng/L,而进行期组血清IL-18和IP-10水平分别为(444.69±14.74)ng/L和(355.47±6.95)ng/L。进行期组及静止期组的IL-18和IP-10血清水平均较正常对照组明显升高(均为P<0.05)。结论:IL-18和IP-10可能与银屑病发生、发展有关。 相似文献
97.
Psoriatic Arthritis: Interrelationships between Skin and Joint Manifestations Related to Onset,Course and Distribution 总被引:4,自引:0,他引:4
To assess the relationships between skin and joint disease, 70 patients with psoriatic arthritis were consecutively evaluated.
Data were obtained regarding age, sex, duration of disease, age at onset, and flares of both skin and joint disease. Rheumatological
assessment included morning stiffness, number of swollen, tender and deformed joints, involvement of distal interphalangeal
joints (DIP), presence of dactylitis, Achilles tendinitis, and clinical lumbar and cervical involvement. Skin assessment included
recording of the distribution of skin lesions and nail involvement, and grading of psoriasis severity using the PASI. The
scalp was the most frequently involved site. Significant correlation was found between the PASI score and the number of deformed
joints and Schober’s test. The scalp score was found to correlate with the number of swollen joints, deformed joints, sausage
finger and DIP involvement. Synchronous flares of skin and joint were significantly more frequent in the patients with onset
of skin and joint diseases within the same year. Likewise, these patients showed a highly significant association between
the PASI score and the number of tender, swollen and deformed joints, Schober’s test and cervical involvement, whereas no
such associations were found among patients with separate onset of skin and joint diseases.
Received: 9 August 1999 / Accepted: 10 February 2000 相似文献
98.
银屑病是一种慢性T细胞介导的炎性、增殖性和复发性皮肤病。随着对银屑病发病免疫学机制的深入研究,一些具有靶位特异性的生物制剂相继出现,包括融合蛋白、单克隆抗体、重组细胞因子等,在临床应用中具有靶向特异性、毒副作用少并取得了可喜的治疗效果。本文对银屑病的免疫学基础、生物免疫治疗学机制及临床疗效评价进行了综述。 相似文献
99.
Liu ChunshanLaizhou Hospital of TCM Laizhou China Xie RenyuInstitute of Acupuncture-Moxibustion China Academy of TCM Beijing China 《世界针灸杂志》1995,(2)
The author has treated 48 cases of psoriasis using long needle combined with cup-ping.of 48 cases,32 cases(67%)were cured,10(21%)markedly effective,6(12%)effective.Thetotal effective rate was 100%. 相似文献
100.
目的分析总结昆明地区银屑病患者在病因、临床表现、治疗等方面的情况,以提高临床诊疗水平.方法回顾性调查并分析2002~2003年昆明地区 208例银屑病患者的各项临床情况.结果遗传、感染、药物等因素在寻常型银屑病的发病中作用较大,脓疱型及红皮症型的发病多与治疗不当有关;外用新型的皮质类固醇及维甲酸类制剂可取得较好的治疗效果.结论银屑病的临床表现多样,病因复杂,可能存在着地区差异,新一代药物的治疗前景广阔. 相似文献