全文获取类型
收费全文 | 3008篇 |
免费 | 97篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 8篇 |
妇产科学 | 11篇 |
基础医学 | 212篇 |
口腔科学 | 4篇 |
临床医学 | 136篇 |
内科学 | 146篇 |
皮肤病学 | 1750篇 |
神经病学 | 8篇 |
特种医学 | 51篇 |
外科学 | 70篇 |
综合类 | 266篇 |
预防医学 | 70篇 |
眼科学 | 5篇 |
药学 | 201篇 |
1篇 | |
中国医学 | 176篇 |
肿瘤学 | 17篇 |
出版年
2024年 | 5篇 |
2023年 | 79篇 |
2022年 | 101篇 |
2021年 | 134篇 |
2020年 | 152篇 |
2019年 | 100篇 |
2018年 | 89篇 |
2017年 | 96篇 |
2016年 | 131篇 |
2015年 | 111篇 |
2014年 | 213篇 |
2013年 | 179篇 |
2012年 | 159篇 |
2011年 | 149篇 |
2010年 | 127篇 |
2009年 | 100篇 |
2008年 | 99篇 |
2007年 | 95篇 |
2006年 | 96篇 |
2005年 | 73篇 |
2004年 | 63篇 |
2003年 | 70篇 |
2002年 | 63篇 |
2001年 | 46篇 |
2000年 | 50篇 |
1999年 | 61篇 |
1998年 | 55篇 |
1997年 | 42篇 |
1996年 | 40篇 |
1995年 | 45篇 |
1994年 | 36篇 |
1993年 | 25篇 |
1992年 | 17篇 |
1991年 | 26篇 |
1990年 | 22篇 |
1989年 | 19篇 |
1988年 | 17篇 |
1987年 | 16篇 |
1986年 | 17篇 |
1985年 | 13篇 |
1984年 | 13篇 |
1983年 | 6篇 |
1982年 | 11篇 |
1981年 | 17篇 |
1980年 | 10篇 |
1979年 | 19篇 |
1978年 | 13篇 |
1977年 | 6篇 |
1975年 | 1篇 |
1972年 | 5篇 |
排序方式: 共有3133条查询结果,搜索用时 46 毫秒
41.
《Anais brasileiros de dermatologia》2020,95(4):452-458
BackgroundPsoriasis is a chronic inflammatory disease with systemic repercussions and an association with comorbidities such as metabolic syndrome, cardiovascular diseases, and obesity. Psoriasis patients have a higher prevalence of obesity compared to the general population. Diet is a relevant environmental factor, since malnutrition, inadequate body weight, and metabolic diseases, in addition to the direct health risk, impair the treatment of psoriasis.ObjectivesTo evaluate food intake patterns, anthropometric, and metabolic syndrome-related aspects in psoriasis patients.MethodsCross-sectional study through anthropometric assessment and food frequency questionnaire. Food frequency questionnaire items were evaluated by exploratory factor analysis and identified dietary patterns were analyzed by multivariate methods.ResultsThis study evaluated 94 patients, 57% female, with a mean age of 54.9 years; the prevalence of obesity was 48% and of metabolic syndrome, 50%. Factor analysis of the food frequency questionnaire identified two dietary patterns: Pattern 1 – predominance of processed foods; Pattern 2 – predominance of fresh foods. Multivariate analysis revealed that Patterns 1 and 2 showed inverse behaviors, and greater adherence to Pattern 2 was associated with females, eutrophic individuals, absence of lipid and blood pressure alterations, and lower waist-to-hip ratio and skin disease activity.Study limitationsMonocentric study conducted at a public institution, dependent on dietary memory.ConclusionTwo dietary patterns were identified in a Brazilian sample of psoriasis patients. The prevalence of obesity and metabolic syndrome were greater than in the adult Brazilian population. The fresh diet was associated with lower indicators of metabolic syndrome in this sample. 相似文献
42.
《Actas dermo-sifiliográficas》2020,111(10):835-846
Psoriatic arthritis is a common type of inflammatory arthritis found in up to 40% of patients with psoriasis. Because skin involvement usually precedes joint involvement, dermatologists play a key role in early detection. Early diagnosis is important for reducing the risk of irreversible structural damage, attenuating the deterioration of physical function, and improving patients’ quality of life. This consensus statement was drafted by a group of 9 dermatologists and 1 rheumatologist to provide simple recommendations to help dermatologists screen for psoriatic arthritis in patients with psoriasis. The experts offer consensus-based guidelines that draw on a review of available scientific evidence and on experience acquired in routine clinical practice. 相似文献
43.
目前治疗银屑病的方法较多,但治疗效果令人满意的方法尚少。光疗是治疗银屑病的一种有效方法,与药物联合应用不仅可以提高疗效,还可减少不良反应的发生。现将近年光疗治疗银屑病的研究进展综述如下。 相似文献
44.
Juliana Bastos Costa Virna Lygia Lobo Rocha de Sousa Pedro Bezerra da Trindade Neto Thomás de Aquino Paulo Filho Virgínia Célia Dias Florêncio Cabral Patrícia Moura Rossiter Pinheiro 《Anais brasileiros de dermatologia》2012,87(6):910-913
Norwegian scabies is a highly contagious skin infestation caused by an ectoparasite,
Scarcoptes scabiei var. Hominis, which mainly affects immunosuppressed individuals.
Clinically, it may simulate various dermatoses such as psoriasis, Darier''s disease,
seborrheic dermatitis, among others. This is a case report of a 33-year-old woman,
immunocompetent, diagnosed with generalized anxiety disorder (cancer phobia), who had
erythematous, well-defined plaques, covered with rupioid crusts, on her neck,
axillary folds, breast, periumbilical region, groin area, besides upper back and
elbows, mimicking an extremely rare variant of psoriasis, denominated rupioid
psoriasis. 相似文献
45.
目的:检测存活素(Survivin)、血管内皮生长因子(VEGF)及血管生成素-2(Ang-2)等因子在寻常型银屑病(PV)皮损中的表达。方法:用免疫组化方法检测30例PV皮损及30例正常皮肤组织中Survivin、VEGF及Ang-2的表达。结果:PV皮损中Survivin、VEGF及Ang-2的表达明显强于正常皮肤组织。Survivin,VEGF和Ang-2之间的表达呈正相关。结论:Survivin、VEGF及Ang-2共同参与了银屑病新生血管的生成过程。 相似文献
46.
目的:研究蜈蚣败毒饮对角质形成(Ha Ca T)细胞角蛋白Keratin6 m RNA表达的影响。方法:36只Wistar大鼠随机均分为空白对照(等容生理盐水)组、甲氨蝶呤(0.22 g/100 g)组、复方青黛胶囊(0.26 g/100 g)组与蜈蚣败毒饮高、中、低剂量(11.88、5.94、2.96 g/100 g)组,ig给药,每天2次,连续3 d。末次给药后取腹主动脉血,各组血清作用于相应的Ha Ca T细胞培养24 h。通过实时荧光酶链聚合反应(RT-PCR)法测定Ha Ca T细胞Keratin6 m RNA的表达。结果:与空白对照组比较,各用药组Ha Ca T细胞Keratin6 m RNA表达减弱,蜈蚣败毒饮在减弱Ha Ca T细胞Keratin6 m RNA表达方面呈现出非剂量依赖关系。结论:蜈蚣败毒饮可能通过抑制Keratin6 m RNA的表达,从而降低了Ha Ca T细胞增殖来发挥抗银屑病作用。 相似文献
47.
《Modern rheumatology / the Japan Rheumatism Association》2013,23(4):356-359
AbstractPrimary Sjögren's syndrome (SS), sarcoidosis (SA), and psoriasis vulgaris (PV) are all chronic diseases of unknown etiology. Recent studies suggest that activated T cells play a central role in their pathogenesis. We describe a case of a Japanese woman with primary SS complicated by SA and PV. To our knowledge, this is the first case in which these three diseases coexist. Although these three disorders may have a common immunopathogenic mechanism, the extreme rarity of their coexistence suggests that distinct etiological mechanisms are also involved and appear to play an important role in triggering and developing each disease. 相似文献
48.
49.
50.
J.M. Carrascosa 《Actas dermo-sifiliográficas》2013,104(6):471-479
It is now known that all biologic drugs, even those that are fully human, are immunogenic, that is, they have the ability to induce an immune response in the treated patient. Since the presence of antidrug antibodies may influence the levels and function of the drug in the body, this immune response can alter the efficacy of the biologic treatment and even its safety profile, depending on the mechanism of action (neutralizing or nonneutralizing) and/or an accelerated clearance of the drug. Immunogenicity is a dynamic factor that should be taken into account when prescribing biologic therapy in psoriasis, especially in the case of long-term treatment and when assessing secondary loss of response. An understanding of the immunogenicity of biologic therapies and how this can be managed is useful not only for optimizing the treatment strategy used with each drug, but also for designing predictive models of response and even for tailoring therapy on a case-by-case basis. 相似文献