全文获取类型
收费全文 | 68506篇 |
免费 | 2517篇 |
国内免费 | 512篇 |
专业分类
耳鼻咽喉 | 412篇 |
儿科学 | 810篇 |
妇产科学 | 658篇 |
基础医学 | 7359篇 |
口腔科学 | 3556篇 |
临床医学 | 5067篇 |
内科学 | 12618篇 |
皮肤病学 | 1403篇 |
神经病学 | 5349篇 |
特种医学 | 1895篇 |
外国民族医学 | 2篇 |
外科学 | 12422篇 |
综合类 | 3598篇 |
现状与发展 | 1篇 |
一般理论 | 6篇 |
预防医学 | 6312篇 |
眼科学 | 1195篇 |
药学 | 4248篇 |
24篇 | |
中国医学 | 2449篇 |
肿瘤学 | 2151篇 |
出版年
2023年 | 597篇 |
2022年 | 913篇 |
2021年 | 2062篇 |
2020年 | 1395篇 |
2019年 | 5235篇 |
2018年 | 5434篇 |
2017年 | 3482篇 |
2016年 | 1062篇 |
2015年 | 1031篇 |
2014年 | 1930篇 |
2013年 | 2060篇 |
2012年 | 1501篇 |
2011年 | 1791篇 |
2010年 | 1526篇 |
2009年 | 1279篇 |
2008年 | 1278篇 |
2007年 | 1278篇 |
2006年 | 1095篇 |
2005年 | 898篇 |
2004年 | 716篇 |
2003年 | 709篇 |
2002年 | 496篇 |
2001年 | 557篇 |
2000年 | 451篇 |
1999年 | 421篇 |
1998年 | 277篇 |
1997年 | 268篇 |
1996年 | 231篇 |
1995年 | 222篇 |
1994年 | 195篇 |
1993年 | 157篇 |
1992年 | 150篇 |
1991年 | 137篇 |
1990年 | 93篇 |
1989年 | 93篇 |
1987年 | 96篇 |
1986年 | 88篇 |
1985年 | 2835篇 |
1984年 | 3382篇 |
1983年 | 2860篇 |
1982年 | 3328篇 |
1981年 | 3020篇 |
1980年 | 2513篇 |
1979年 | 2500篇 |
1978年 | 2062篇 |
1977年 | 1535篇 |
1976年 | 1995篇 |
1975年 | 1513篇 |
1974年 | 1325篇 |
1973年 | 1272篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
62.
Ali R. Cohen Thomas J.E. Clark Lynette M. Renner Pamela C. Carter Erin M. Shriver 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》2019,54(3):355-358
ObjectiveDetermine the prevalence of intimate partner violence (IPV) as a mechanism of traumatic ocular injury in women, typical injury patterns, and the clinical course of affected patients. Encourage IPV screening and safety assessment in patients presenting with characteristic ocular trauma.MethodsMedical records of 211 female patients with traumatic ocular injuries evaluated at the University of Iowa Hospitals and Clinics between January 1995 and January 2015 were reviewed to determine the rate of IPV as a mechanism of ocular trauma. Twenty-one patients were excluded due to no documented trauma.ResultsLeading causes of traumatic ocular injuries in the 190 female patients included were accidental trauma with an inanimate object (n = 70/190, 36.8%), falls (n = 52/190, 27.4%), motor vehicle collisions (n = 21/190, 11.1%), and assault (n = 16/190, 8.4%). In 2.1% of cases (n = 4/190), no mechanism of traumatic injury was documented. Assault was the fourth leading mechanism of injury accounting for 8.4% of cases (n = 16/190), with IPV accounting for more than one third of cases with a documented perpetrator (n = 5/13). No perpetrator was documented in 18.8% (n = 3/16). All 5 patients with IPV-related injuries sustained scleral laceration or rupture; 4 out of 5 patients had no light perception vision and ultimately required enucleation.ConclusionIPV is an important mechanism of traumatic ocular injury. IPV-associated injuries tend to be severe in nature, as demonstrated by the high rate of globe laceration or rupture and subsequent enucleation in the study population. By appropriate screening and referral, ophthalmologists have an opportunity to redirect a potentially devastating course. 相似文献
63.
D. Sforza G. Iaria L. Petagna A. Parente A. Anselmo F. Sergi S. Marzio F. Corrado S. Telli T.M. Manzia G. Tisone 《Transplantation proceedings》2019,51(1):140-142
Background
One daily dose of tacrolimus (QDT) improves adherence in kidney transplant (KT) recipients. A switch from twice-daily tacrolimus (BDT) to QDT showed similar efficacy and safety.Methods
The aim of our study was to demonstrate the long-term efficacy and safety of switching from BDT to QDT in KT recipients. Preliminary results have already been published. Forty-one patients (34 men and 7 women), mean age at KT of 43.9 ± 12.7 years, underwent a 1:1 dose switch from BDT to QDT; the mean time from KT to switch was 36.6 ± 16.1 months. In our study population, 4 patients received a living donor KT and 2 received a second allograft.Results
The mean follow-up was 86.8 ± 13 months from the switch and 126.2 ± 22.3 months from KT. Graft and patient survival rates were 90.2% and 95.1%, respectively. All patients maintained stable renal function during follow-up. During the first 3 months after the switch we observed a significant decrease in tacrolimus blood level (P = .0001). No significant differences were observed regarding tacrolimus dose before and after QDT introduction (P = not significant [NS]). Fourteen patients who stopped steroids under BDT treatment and 16 patients who stopped steroids after the switch are currently steroid-free.Conclusion
Our study showed safety and efficacy in switching from BDT to QDT. After early (<1 year) dose adjustment, tacrolimus blood levels remained stable throughout follow-up. Moreover, QDT represented a valid alternative for patients showing steroid side effects. 相似文献64.
65.
《Alzheimer's & dementia》2019,15(12):1507-1515
IntroductionWe estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos.MethodsMiddle-aged and older diverse Hispanics/Latinos enrolled (n = 6377; 50–86 years) in this multisite prospective cohort study were evaluated for MCI using the National Institute on Aging–Alzheimer's Association diagnostic criteria.ResultsThe overall MCI prevalence was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, and elevated depressive symptoms were significant correlates of MCI prevalence. Apolipoprotein E4 (APOE) and APOE2 were not significantly associated with MCI.DiscussionMCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos. 相似文献
66.
67.
68.
Tau Ming Liew 《Journal of the American Medical Directors Association》2019,20(8):1054.e11-1054.e20
ObjectivesEarly diagnosis of cognitive impairment is increasingly emphasized in the literature to facilitate timely preventive interventions. Although bedside cognitive tests such as the Montreal Cognitive Assessment (MoCA) are widely used for such early diagnostic purposes, they may not have comparable performance to a full neuropsychological battery (FNB) in diagnosing early cognitive impairment. This study investigated whether a small subset of neuropsychological tests can be added on to MoCA to match its performance to that of the FNB in discriminating mild cognitive impairment and dementia (MCI/dementia) from normal cognition.DesignCross-sectional diagnostic study.SettingAlzheimer's Disease Centers across the United States.ParticipantsOlder participants (≥50 years) who completed MoCA and the FNB (N = 9187).MeasuresThe study sample was split into two: the derivation sample (n = 1837) was used to develop a brief neuropsychological battery that best discriminated MCI/dementia (using the best-subset approach with 10-fold cross-validation); while the validation sample (n = 7350) verified its actual performance in discriminating MCI/dementia.ResultsA 3-item neuropsychological battery was identified, comprising MoCA, Benson Complex Figure Recall, and Craft Story 21 Delayed Recall. It had excellent performance in discriminating MCI/dementia from normal cognition (area under the receiver operating characteristic curve [AUROC] 90.0%, 95% confidence interval [CI] 89.2%-90.7%), which was comparable to that of the FNB (AUROC 88.4%, 95% CI 87.6%-89.2%). By contrast, MoCA alone had significantly worse AUROC (86.9%, 95% CI 86.0%-87.7%) than that of the FNB.Conclusions/ImplicationsUsing rigorous methods, this study developed a brief neuropsychological battery that maintained the brevity of a bedside cognitive test, while rivaling the diagnostic performance of an FNB in early cognitive impairment. This brief battery offers a viable alternative when the FNB is needed but cannot be feasibly administered in nonspecialty clinics. It can have a wider health systems effect of improving patients’ access to accurate diagnosis in early cognitive impairment and facilitating timely interventions to delay the progression of cognitive impairment. 相似文献
69.
内听动脉闭塞综合征的临床与发病机理 总被引:1,自引:0,他引:1
目的:探讨内听动脉闭塞综合征的临床与发病机理。方法:分析24例患者年龄、性别及所伴发疾病如高血压病、糖尿病、冠心痛及椎-基底动脉供血不足等。结果:50岁以上,有高血压病、冠心病、糖尿病、椎-基底动脉供血不足者内听动脉闭塞发病明显增加。结论:高血压病、冠心病、糖尿病、椎基底动脉供血不足是内听动脉闭塞综合征的主要危险因素。 相似文献
70.
N Simelela 《International journal of gynaecology and obstetrics》2006,94(3):292-300
Preventing unintended pregnancies through access to modern family planning could avert 20-35% of maternal deaths, saving the lives of more than 100,000 women each year. Obstacles to wider access still exist, but they may be overcome by overt policy commitment to reproductive health services, partnership between stakeholders, community involvement and quality programs. 相似文献