蒙药紫癜灵治疗过敏性紫癜260例临床报告

目的：观察蒙药紫癜灵对过敏性紫癜的临床疗效。方法：根据年龄大小服用紫癜灵，日服2～3次，温开水送服。结果：共观察260例，其中治愈234例，占90％；显效13例，占5％；有效11例，占4％；无效2例，占1％。总有效率为99％。结论：蒙药紫癜灵对过敏性紫癜有很好的治疗作用。     

我国主要少数民族医药防治缺血性心脏病研究概述

我国缺血性心脏病发病率逐年增加，给家庭和社会造成了严重的负担，亟待寻找更好的治疗手段和医疗方案。基于象数思维、整体观等思维方式和临床经验，我国主要少数民族医药逐渐发展出独特的理论体系与治疗特色，在防治缺血性心脏病方面具有极大的应用潜力及研究价值。其中藏族医药（以下简称“藏医药”）、蒙古族医药（以下简称“蒙医药”）、傣族医药（以下简称“傣医药”）均可归属于以自然观与生命观为哲学基础的医学系统，各自发展出“三因”“三根”“四塔五蕴”理论，形成了对缺血性心脏病的独特认识并提出了相应的治法治则，产生了以三味檀香散、八味沉香散、肉蔻五味丸、雅叫哈顿散为代表的经典方剂，并具有以广枣、红景天、血竭为代表的特色民族药资源。笔者拟以藏医药、蒙医药为主，归纳民族医药防治缺血性心脏病的相关研究，并探讨开展该类研究所面临的机遇和挑战，以期为民族药防治缺血性心脏病的临床应用及新药开发研究提供参考。     

中蒙医药结合治疗外阴白斑50例疗效分析

目的:观察女性外阴白色病变用中蒙药结合的治疗效果.方法:采用中药汤剂、散剂内服；中药粗粉剂冲泡外洗；蒙药制成膏剂外敷；阴道放药等综合治疗方法,对女性外阴白色病变进行治疗观察.结果:治疗50例,痊愈20例,显效23例,有效5例,无效2例.结论:采用中蒙药结合,内外同治的综合方法治疗女性外阴白色病变,疗效满意.     

瓜蒌化学、药理及临床应用探讨

总结瓜蒌已有的实验和临床研究成果,分析瓜蒌的化学成分特点,探讨综合利用瓜蒌的途径。瓜蒌含有糖苷类、色素等成分,具有抗心肌缺血、抗心肌纤维化等作用。在冠心病心绞痛、肺源性心脏病等临床方面疗效较好。     

Evidence for the origin of the binaural interaction component of the auditory brainstem response

The binaural interaction component (BIC) represents the mismatch between auditory brainstem responses (ABR) obtained with binaural stimulation and the sum of ABRs obtained with monaural left and right stimulation. It is generally assumed that the BIC reflects binaural integration. Its potential use as a diagnostic tool, however, is hampered by the lack of direct evidence about its origin. While an origin at the initial site of binaural integration seems likely, there is no general agreement on the contribution of the two primary candidate nuclei, the lateral and medial superior olives (LSO and MSO, respectively). Here, we recorded local field potentials (LFP) and responses of units in the LSO and MSO of Mongolian gerbils (Meriones unguiculatus), presenting clicks with an interaural time or level difference (ITD and ILD, respectively), while simultaneously recording ABR. We determined the BIC from the ABR and, importantly, from LFP and responses of units in the LSO and MSO. If stimulus‐induced changes in the ABR‐derived BIC have their source in the LSO and/or MSO, we expect coherent changes in the unit‐derived and the ABR‐derived BIC. We find that BIC obtained from LSO units exhibits the same ITD and ILD dependence as the ABR‐derived BIC. Neither BIC obtained from MSO units nor LFP‐derived BIC recorded in either LSO or MSO did. The data thus strongly suggest that it is the activity of LSO units in the gerbil that is decisive for the generation of the ABR‐derived BIC, determining its properties.     

Evaluation of combined antibiotic-omeprazole therapies in Helicobacter pylori-infected Mongolian gerbils

Mongolian gerbils are a laboratory host for gastric colonization with Helicobacter pylori, showing gastritis followed by typical gastric ulcer after infection with H. pylori. In such gerbils, we evaluated combined therapies of amoxicillin (AMPC) and clarithromycin (CAM) as antibiotics, and omeprazole (OPZ) as a H⁺/K⁺ adenosine triphosphatase (ATPase) inhibitor. The gerbils were orally inoculated with 2 × 10⁸ bacilli of ^{H. pylori} ATCC 43504. Four weeks after inoculation, the infected gerbils were orally treated singly with OPZ, AMPC, and CAM, and their insufficient efficacy on bacterial clearance was confirmed by a polymerase chain reaction technique, and by a culture method. In contrast, combined therapy of OPZ plus either AMPC or CAM showed significant bacterial clearance, demonstrating the efficacy of this combined therapy in the gerbil model. Mongolian gerbils are suggested to be useful for the pharmacological evaluation of anti-H. pylori compounds. Received Mar. 11, 1997; accepted June 27, 1997     

正交试验优选蒽酮 硫酸法测定蒙药“那仁满都拉”水溶性糖含量条件

摘 要 目的： 优选蒽酮 硫酸法测定蒙药“那仁满都拉”水溶性糖含量试验条件,并对蒙药“那仁满都拉”水溶性糖进行含量测定。方法: 在单因素试验基础上,对影响水溶性糖含量测定的四个因素：反应温度、反应时间、硫酸浓度,蒽酮浓度进行正交试验设计,优选最佳测定条件。结果: 蒽酮 硫酸法测定蒙药“那仁满都拉”水溶性糖含量的最佳条件为：反应温度80℃、反应时间45 min、硫酸浓度75%、蒽酮浓度0.2%。在此条件下,葡萄糖在2.040 0～32.580 0 mg·mL^-1范围内线性关系良好,r=0.999 6,平均回收率为101.88%,RSD为0.69%。三批样品含量测定的RSD均小于0.95%。结论: 用蒽酮 硫酸法测定“那仁满都拉”中的水溶性糖含量时,显色条件对定量有不容忽视的影响。     

对几种蒙药成方剂型微生物检查的分析

目的：通过对4种蒙药成方剂型进行质量检查,分析微生物超标的直接原因。方法：按照《中国药典》2010版第一部附录制剂通则及微生物限度检查法进行实验。结果：4个制剂微生物均不符合规定。结论：与方内糖类和淀粉类成分有关。     

蒙药镇刺六味丸的质量标准研究

目的：建立蒙药镇刺六味丸质量标准研究方法。方法：采用薄层色谱法、高效液相色谱法进行处方中单药的专属性薄层色谱鉴别、有效成分士的宁的含量测定。色谱条件：Shim-pack VP-ODS 150L*4.6;流动相：乙腈∶0.01mol/L庚烷磺酸钠与0.02mol/L磷酸二氢钾等量混合溶液（加10%磷酸调节pH值至2.8）＝（21∶79）;检测波长：260nm;流速为1.0mL/min;柱温：室温;进样量：10μL。参照《中国药典》（2010版）进行了一般检查项目的研究。结果：采用薄层鉴别法对处方中的单味药进行鉴别研究,样品和对照品在薄层板相应的位置均出现相同的特征斑点,阴性对照品相应的位置没有出现干扰。用HPLC法测定该药中士的宁的含量,士的宁进样量在10～400μg时与峰面积呈良好的线性,平均回收率为100.54.%（RSD=2.06%）。结论：本研究采用的定性和定量分析方法简便、快捷、专属性和重复性好、结果准确可靠,为建立和完善蒙药镇刺六味丸的质量标准提供科学依据。     

Persistent infection of Strongyloides venezuelensis and normal expulsion of Nippostrongylus brasiliensis in Mongolian gerbils, Meriones unguiculatus, with reference to the cellular responses in the intestinal mucosa

The kinetics of daily faecal egg count, worm burdens, and intestinal cellular responses were examined in Mongolian gerbils after infection with either Strongyloides venezuelensis or Nippostrongylus brasiliensis alone, or concurrently with both parasites. The results show that, both in individual and concurrent infections, S. venezuelensis infection persisted for over 10 weeks and elicited a gradual increase in number of mast cells in the jejunal mucosa. On the other hand, N. brasiliensis worms were expelled by 3 weeks in association with goblet cell hyperplasia. These results suggest that effector/regulator cells involved in worm expulsion are different and highly selective depending on the genus of intestinal helminths.