全文获取类型
收费全文 | 1254篇 |
免费 | 58篇 |
国内免费 | 42篇 |
专业分类
耳鼻咽喉 | 181篇 |
儿科学 | 29篇 |
妇产科学 | 20篇 |
基础医学 | 182篇 |
口腔科学 | 37篇 |
临床医学 | 75篇 |
内科学 | 154篇 |
皮肤病学 | 13篇 |
神经病学 | 56篇 |
特种医学 | 14篇 |
外科学 | 136篇 |
综合类 | 92篇 |
预防医学 | 101篇 |
眼科学 | 11篇 |
药学 | 51篇 |
中国医学 | 15篇 |
肿瘤学 | 187篇 |
出版年
2024年 | 4篇 |
2023年 | 22篇 |
2022年 | 40篇 |
2021年 | 49篇 |
2020年 | 20篇 |
2019年 | 31篇 |
2018年 | 21篇 |
2017年 | 28篇 |
2016年 | 50篇 |
2015年 | 47篇 |
2014年 | 78篇 |
2013年 | 83篇 |
2012年 | 66篇 |
2011年 | 49篇 |
2010年 | 72篇 |
2009年 | 55篇 |
2008年 | 72篇 |
2007年 | 57篇 |
2006年 | 47篇 |
2005年 | 67篇 |
2004年 | 64篇 |
2003年 | 40篇 |
2002年 | 39篇 |
2001年 | 40篇 |
2000年 | 23篇 |
1999年 | 33篇 |
1998年 | 27篇 |
1997年 | 26篇 |
1996年 | 21篇 |
1995年 | 11篇 |
1994年 | 13篇 |
1993年 | 8篇 |
1992年 | 3篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1988年 | 4篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 6篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1973年 | 3篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有1354条查询结果,搜索用时 31 毫秒
21.
对18例20耳8~14岁突发性感音神经性听力损失患儿的临床资料进行了总结和分析,结果表明儿童突发性感音神经性听力损失发病与首诊之间病程较长,部分患儿有上感、流行性腮腺炎病史,可能和听力损失发生有关.儿童突发性感音神经性听力损失治疗效果类似于成人患者,而全聋者疗效差.东菱克栓酶同样适于治疗儿童突发性感音神经性听力损失且疗效和安全性较好,无明显的出血倾向和其它并发症. 相似文献
22.
Association of Loss of Heterozygosity at the p53 Locus with Chemoresistance in Osteosarcomas 总被引:4,自引:0,他引:4
Akiteru Goto Hiroaki Kanda Yuichi Ishikawa Seiichi Matsumoto Noriyoshi Kawaguchi Rikuo Machinami Yo Kato Tomoyuki Kitagawa 《Cancer science》1998,89(5):539-547
Although the osteosarcoma is considered to be among the most chemosensitive malignancies and preoperative chemotherapy is commonly applied, an appreciable proportion of cases are in fact quite insensitive. Predictive markers for chemosensitivity are therefore desirable in order to develop effective treatment strategies. Thirty-two cases of conventional osteosarcomas treated at the Cancer Institute Hospital, Tokyo, were analyzed. The sensitivity to preoperative chemotherapy was investigated with reference to loss of heterozygosity (LOH) at the 17p13 ( p 53) and 13q14 ( Rb ) loci and expression of the cell-cycle associated proteins, p53, Rb, p21/Waf-1, mdm-2 and Ki-67, as detected immunohistochemically. LOH was detected by analyzing polymerase chain reaction products at marker microsatellite loci. The efficacy of chemotherapy was evaluated both radiologically and histologically. LOH at p 53 or Rb loci was seen in 54% (13/24) and 58% (14/24) of cases, respectively. Only 15% of osteosarcomas with LOH at the p 53 locus were sensitive to preoperative chemotherapy, as compared to 64% of tumors without such loss ( P <0.05). A similar but much less distinct tendency was observed with LOH at the Rb locus. No relationship was evident between chemosensitivity and immunohistochemical staining patterns for p53, Rb, p21/Waf-1, mdm-2 or Ki-67. The results suggest that p 53 gene deletion, but not the other parameters investigated, may be useful for predicting chemoresistance of osteosarcomas. 相似文献
23.
24.
目的微卫星(microsatellite)是广泛分布于生物基因组中的DNA重复序列,与许多重要基因紧密连锁。本研究旨在探讨食管癌变多阶段演进过程中微卫星DNA杂合缺失(loss of heterozygosity,LOH)的特征及其意义。方法采用微卫星DNA多态分析法,选取染色体3p、5q、6p、9p、13q、17p、17q和18q的15个多态微卫星位点,对32例食管癌前病变和癌组织进行LOH分析。结果食管各级癌前病变组织和癌组织均出现不同程度的微卫星DNALOH,其频率随病变程度加重而明显升高(除D9S1752位点外,P均〈0.05);其中D9S171、D13S260和TP53位点在癌阶段,LOH频率均超过60%。各级癌前病变组织和癌组织中发生LOH的位点不尽相同,同一个体从基底细胞过度增生→间变→原位癌→鳞状细胞癌,均发生LOH的位点是:D3S1234和TP53。结论基因水平的改变发生在食管癌变的早期阶段,随病变程度加重,基因组不稳定性增强,可能是导致食管癌前病变持续向癌的方向发展的重要机制之一。 相似文献
25.
《The Journal for Nurse Practitioners》2017,13(10):667-674.e1
Acute kidney injury (AKI) is a complex disease process that is increasingly common and has an increased rate of adverse outcomes and mortality. It is commonly underdiagnosed in inpatient and community settings by many providers. This article is a comprehensive review of AKI from risk factors to diagnosis to management and follow-up. 相似文献
26.
Kaare Solheim Knut A. Evensen Bjørn Høivik Steinar Karlsen Arne R. Rosseland 《Scandinavian cardiovascular journal : SCJ》2013,47(1):61-64
AbstractTwo operated cases of aorto-caval fistula due to ruptured abdominal aneurysm are reported. This is a rare and real surgical emergency and is fatal without operation. The classical symptoms of high-output failure occurring simultaneously with the findings of an expansible abdominal mass with thrill and bruit should facilitate clinical diagnosis. 相似文献
27.
28.
29.
《Acta oto-laryngologica》2012,132(6):724-730
This study provides normative data from computerized electronystagmography (ENG) testing of 40 healthy subjects with an average age of 45 years. The clinical test protocol comprises an extensive vestibular examination with oculomotor, positional, rotary chair and caloric tests. The results show that with a computerized ENG set-up considerable variabilities of 22% for rotary chair asymmetry and 19% for caloric labyrinth asymmetry remain. 相似文献
30.
Renata Beatriz Fernandes Santos Andrea Tortosa Marangoni Adriana Neves de Andrade Raquel Prestes Daniela Gil 《Clinics (S?o Paulo, Brazil)》2014,69(12):835-840
OBJECTIVE:To determine the effects of a formal auditory training program on the behavioral, electrophysiological and subjective aspects of auditory function in individuals with bilateral high-frequency hearing loss.METHOD:A prospective study of seven individuals aged 46 to 57 years with symmetric, moderate high-frequency hearing loss ranging from 3 to 8 kHz was conducted. Evaluations of auditory processing (sound location, verbal and non-verbal sequential memory tests, the speech-in-noise test, the staggered spondaic word test, synthetic sentence identification with competitive ipsilateral and contralateral competitive messages, random gap detection and the standard duration test), auditory brainstem response and long-latency potentials and the administration of the Abbreviated Profile of Hearing Aid Benefit questionnaire were performed in a sound booth before and immediately after formal auditory training.RESULTS:All of the participants demonstrated abnormal pre-training long-latency characteristics (abnormal latency or absence of the P3 component) and these abnormal characteristics were maintained in six of the seven individuals at the post-training evaluation. No significant differences were found between ears in the quantitative analysis of auditory brainstem responses or long-latency potentials. However, the subjects demonstrated improvements on all behavioral tests. For the questionnaire, the difference on the background noise subscale achieved statistical significance.CONCLUSION:Auditory training in adults with high-frequency hearing loss led to improvements in figure-background hearing skills for verbal sounds, temporal ordination and resolution, and communication in noisy environments. Electrophysiological changes were also observed because, after the training, some long latency components that were absent pre-training were observed during the re-evaluation. 相似文献