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101.
通过电化学共沉积方法制备具有生物活性的有机高聚物/钙磷陶瓷复合膜层。用XPS、SIMS等对复合膜层的化学组分进行表征,证明少量有机高聚物可能在分子层次上掺杂形成有机高聚物/羟基磷灰石复合膜层。对电沉积HAP陶瓷膜层进行微刮痕实验表明,陶瓷膜层与金属基体的结合力得到显著改善。  相似文献   
102.
Osteosarcoma is one of the neoplasms that may occur following exposure to radiation. A case of osteosarcoma arising in the craniofacial bone with a short latency period of 3 years after radiotherapy for maxillary squamous cell carcinoma is described. A 64-year-old-man underwent right partial maxillectomy and chemoradiotherapy due to squamous cell carcinoma of his right maxillary sinus. Histologically, the tumor was composed of moderately differentiated squamous cell carcinoma with a component of spindle cell carcinoma. Three years later, osteosarcoma developed in the craniofacial bone within the irradiation field of the first tumor. Detailed histological examination demonstrated that there was no component of osteosarcoma in the first tumor or squamous cell carcinoma in the second tumor. Radiation-induced osteosarcoma usually occurs after a long latency period of more than 10 years after the radiotherapy. In this case, osteosarcoma was possibly a radiation-induced osteosarcoma with a short latency period of 3 years.  相似文献   
103.
104.
低强度脉冲电磁场对大鼠骨质疏松的影响   总被引:1,自引:0,他引:1  
目的:观察低强度脉冲电磁场(pulsed electromagnetic fields,PEMFs)对去卵巢诱导骨质疏松症的大鼠生化指标和骨应力的影响。方法:雌性SD大鼠30只,随机等分为3组(n=10),分别为假手术组(Sham)、骨质疏松模型组(Model)、脉冲电磁场照射组(PEMFs)。经适应4wk后,在25mg·Kg^-1戊巴比妥钠腹腔麻醉下,Model组和PEMFs组摘除双侧卵巢.Sham组找到但不切除卵巢。各实验组均在相同环境下饲养,模型制备4wk后开始治疗,由GZY型低强度低频率脉冲电磁场发生仪产生低频脉冲磁场,根据实验要求,我们使用亥姆霍兹线圈形成均匀磁场,PEMFs组经照射刺激治疗,频率14.3Hz,场强2Gs.日照8h。Model组和Sham组正常饲养。治疗8wk后,对各组大鼠血清、尿液中ALP和Ca以及骨应力进行检测。结果:(1)ALP、Ca检测结果:与Model组相比,PEMFs组ALP值、Ca值差异均有统计学意义(P〈0.05)。其中,血清中ALP值,Model组为(275.16±228,57),PEMFs组为(179.30±87.68);Ca值,Model组为(2,66±0,13),PEMFs组为(2.52±0.05)。(2)骨应力检测结果:Model组为(923.60±34.15Pa),PEMFs组为(1152.85±118,20Pa),组间差异有统计学意义(P〈0.05)。结论:研究发现,PEMFs对于促进骨重建、提高Ca吸收和骨应力恢复具有积极作用。  相似文献   
105.
Summary The anatomic constraints imposed on a total artificial heart (TAH) require specific anatomic studies. A thoracic anatomic study was performed with a scanning device equipped with three-dimensional (3-D) reconstruction software on 15 male patients, between the ages of 41 to 63 years (52 ± 6 years). All were candidates for heart transplantation. The 3-D reconstructions of the cardiovascular structures obtained from surgical anatomy data specific to TAH implantation allowed a volumetric measurement of these structures. A modeling diagram of these structures permitted reproducible quantitative measurements of the 35 geometrical parameters which characterized shape, orientation, and position of these structures within the thorax. Most of the measured parameters were characterized by low variability (coefficient of variation from 10 to 25%).
Modélisation tridimensionnelle de l'anatomie du cur et des gros vaisseaux
Résumé Les contraintes anatomiques imposées au cur artificiel total (CAT) nécessitent des études anatomiques spécifiques. Une étude anatomique thoracique a été réalisée avec un scanner doté d'un logiciel de reconstruction tridimensionnelle (3-D) chez 15 patients, tous de sexe masculin, agés de 41 à 63 ans (52 ± 6 ans), et candidats à une transplantation cardiaque. Les reconstructions 3-D des structures cardio-vasculaires réalisées selon les données de l'anatomie chirurgicale propre à l'implantation du CAT ont permis la mesure volumétrique de ces structures. Un schéma de modélisation de ces structures a permis des mesures quantitatives reproductibles de 35 paramètres géométriques caractéristiques de la forme, de l'orientation, de la position de ces structures dans le thorax. Les résultats de ces mesures ont pu être exprimés en termes statistiques. La plupart des paramètres mesurés étaient caractérisés par une faible variabilité (coefficients de variations de 10 à 25%).
  相似文献   
106.
Tumor metastases are extremely rare in striated muscles. This is surprising given the fact that this tissue constitutes 60% of body weight. The present study focuses on small molecules produced and secreted by muscle cells which possess anti-cancer activity in vivo. Recently we have shown that a low molecular weight fraction (<1000 Dalton) of skeletal muscle cell conditioned medium (muscle factor-MF), markedly inhibits the proliferation of carcinoma, sarcoma or melanoma cell lines in vitro. The MF exerts a cytostatic effect on tumor cell growth and arrests the cells in the G0/G1 of the cell cycle. However, normal cell proliferation, such as bone marrow and fibroblasts, was stimulated following incubation with MF. In this study, the effect of orally administered MF on melanoma and sarcoma growth was examined in mice. The administration of MF to mice inoculated intravenously with melanoma (B16–F10) or sarcoma (MCA-105) cells, resulted in a statistically significant inhibition of metastatic lung foci. In a different model, melanoma was induced in the foot pad and after development of a local lesion, the leg was amputated. A prolonged survival time was observed in the MF treated groups. Since the MF stimulated bone marrow cell proliferation in vitro, we decided to test its efficacy as an inhibitor of the myelotoxic effect exerted by chemotherapy, in vivo. MF, administered after chemotherapy, restored the number of white blood cells and yielded an increased percentage of neutrophils compared with the decline in these parameters after administration of chemotherapy alone. Thus, it is indicated that MF exerted a systemic anti tumor and chemoprotective effect when given orally. It can be concluded that it is bioavailable and is not biodegradable in the digestive system. MF may be considered as a potential therapy for the prevention of tumor spread. This revised version was published online in July 2006 with corrections to the Cover Date.  相似文献   
107.
Artificial circulation has been analyzed by decomposing it into parts. However, the sum of the decomposed parts is not equal to the whole system, especially in nonlinear dynamic systems such as biological systems. To evaluate prosthetic circulation as an entity, not as decomposed parts, nonlinear mathematical analytic techniques, including fractal dimension analyzing theory, were used. Two pneumatically actuated ventricular assist devices were implanted as biventricular bypasses (BVB) in chronic animal experiments using four healthy adult goats. For comparison between natural and prosthetic circulation in the same experimental animals, the BVB-type complete prosthetic circulation model with ventricular fibrillation was adopted. All hemodynamic parameters with natural and prosthetic circulation were recorded under awake conditions and calculated by a personal computer system. By the use of nonlinear mathematical techniques, time-series data of the hemodynamics were embedded into the phase space, and correlation dimension analysis was performed to evaluate the reconstructed attractor. Our results suggest that the correlation dimension of the arterial blood pressure does not linearly increase according to the increase of the embedding dimension, even during artificial circulation, suggesting those are the fractal time series data. Dimensional analysis of the hemodynamics revealed that lower dimensional fractal dynamics were observed during prosthetic circulation. Fractal time series data are suggested to have robustness and error resistance. Thus, our results suggest that the circulatory regulatory system with the artificial heart may have these desirable characteristics. Accepted: July 14, 1995  相似文献   
108.
根据下頜光弹的等倾线图,描绘出主应力迹线规迹。在下颌侧位X线照片和去除唇侧及颊侧密质骨板的标本上,观察骨密质和松质的配布,以及骨小梁的排列和方向,试行探讨骨小梁方向与主应力迹线的关系。用光弹法求得的主应力迹线有两个系列:S_1系在下颌体近水平方向,在下颌支近垂直方向分布;S_2系力线与S_1系诸力线呈正交。在标本和X线照片上,主应力迹线规迹不同程度地在骨小梁的排列上有所反映。  相似文献   
109.
碱性成纤维细胞生长因子 (b FGF)是近年来研究较为广泛的生长因子之一 ,对骨组织有着广泛的生物学效应。本文就 b FGF的研究进展及其目前在骨组织工程学研究方面的应用做一综述  相似文献   
110.
Sclerosteosis: report of a case in a black African man   总被引:3,自引:0,他引:3  
Sclerosteosis is a rare genetic disorder of bone modelling, similar to, but distinct from, van Buchem disease; it has been described almost exclusively in Afrikaners of South Africa, a white population of Dutch ancestry. Isolated cases have been reported in a girl in Japan, a boy in Spain, and in multiracial families in Brazil and USA.
Here we report a case of sclerosteosis in a black man born in Senegal. He presented with the full features of the disease: tall stature; syndactyly; nail dysplasia; massive sclerosis of the long tubular bones, the ribs, the pelvis and the skull; multiple cranial nerve involvement: optic atrophy, facial palsy and trigeminal neuralgia. Radiologic examination, visual and brainstem auditory evoked potentials, computerized tomography and magnetic resonance imaging of the skull were performed. This seems to be the first case of the disease in a black African individual, with no known relationship with Dutch ancestry.  相似文献   
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