Fibrosarcoma arising from gouty tophi: report of a unique case and review of literature

Fibrosarcoma is a malignant mesenchymal tumor. To the author’s best knowledge, no previous case of fibrosarcoma arising from gouty tophi has been reported. Here we reported the first case of fibrosarcoma arising from gouty tophi. A case of 58-year-old man was presented with a mass with ulcer and infection in the second joint of left middle finger for 2 months, with long standing gouty tophi. The tumor was biopsied and the biopsy showed complete excision of the tumor. With the pathological and immunohistochemical features considered, the diagnosis of fibrosarcoma associated with gouty tophi was made. The clinical findings, pathological characteristics and treatment were described.     

Acute respiratory distress due to fibrosarcoma of the carina in a child

We report a 12-year-old boy with primary bronchopulmonary fibrosarcoma (PBPF). He was misdiagnosed a having asthma until he presented with acute respiratory distress syndrome. Chest x-ray showed atelectasis of the right lung. Bronchoscopy performed to rule out foreign body inhalation revealed a friable mass obstructing the right main bronchus. Successful treatment was achieved with surgical resection of the lesion followed by radiotherapy and chemotherapy.     

Malignant Fibrous Histiocytoma: An Ultrastructural Perspective

Malignant fibrous histiocytoma is a frequent diagnosis, but the relationship of the tumors to histologically similar soft tissue neoplasms is controversial. In this study, 157 examples representing the 4 main subtypes were reviewed by light microscopy and each tumor was studied with the electron microscope. Immunohistochemical stains were performed on 77 tumors. Electron micrographs on 100 fibrosarcomas were reviewed for comparison. Malignant fibrous histiocytomas often closely resemble fibrosarcomas at the ultrastructural level and differences between the two are generally of degree only. Evidence for true histiocytic differentiation was not found. The immunohistochemical results did not contradict the authors' impression from electron microscopy that malignant fibrous histiocytoma forms part of the histologic spectrum of tumors of fibroblasts.     

Fibrosarcoma of the mandible: case report of a unique radiographic appearance

Fibrosarcoma is a rare malignant fibroblastic neoplasm that only rarely affects the oral cavity. Here, we describe a rare case of fibrosarcoma affecting the mandible of a 10-year-old girl. Orthopantomography showed a well-defined radiolucency with a cortical rim typical of a benign lesion. However, occlusal radiographs showed Codman’s triangle, indicating the malignant nature of the lesion. Computed tomography showed a radiolucent lesion involving the buccal aspect of the mandible, and histopathological examination confirmed the diagnosis. The patient underwent surgical resection of the tumor and is currently undergoing regular follow-up examinations.     

Un nouveau cas de fibrosarcome à localisation digitale

Fibrosarcoma of finger is a very rare entity. We report a new case in a 25-year-old man admitted for an ulcerative and papillary large mass tumor, pinkish purplish color, developed in the left middle finger. Histological diagnosis was established before and after curative surgical treatment. Proximal amputation of the left third finger was performed with metacarpal extirpation and osteotomy in the capitatum according Peze and Iselin procedure. Two years later, functional results were satisfactory without local recurrence or metastasis.     

Two unusual congenital tumors with long-term follow-up after local surgical resection

We report two cases of rare congenital neoplasms (fibrosarcoma and hemangiopericytoma) in which the sole mode of treatment was surgical resection. There has been no local recurrence or metastatic disease in 18 and 15 years of follow-up, respectively. The more optimistic prognosis of these congenital tumors in comparison with their adult counterparts is emphasized, current methods of treatment are discussed, and the results of DNA ploidy analyses are provided. Correspondence to: R. W. Byard     

Fibrosarcoma in association with a total knee joint prosthesis

Summary A case of fibrosarcoma of the proximal tibia, arising at the site of a cemented Richards total knee joint replacement with cobalt chrome alloy is reported. The patient, an 80-year-old man, received the endoprosthesis because of osteoarthritis of the knee 4 years ago. The literature on malignant tumours occurring in association with endoprostheses is summarized and briefly discussed.     

组织因子在纤维肉瘤细胞血管外游走中的作用

目的:评价组织因子对纤维肉瘤细胞血管外游走的影响,明确组织因子与纤维肉瘤细胞血行转移的相关性。方法:应用流式细胞仪检测组织因子在纤维肉瘤细胞(HT1080)的表达情况;在体外模拟肿瘤细胞血管外游走过程,构建充分融合的单层血管内皮细胞及血管外基质,定量评价HT1080向血管外游走的状况。结果:应用流式细胞仪检测出组织因子在HT1080上有强表达;HT1080可以穿过单层血管内皮细胞游走至血管外基质,具有时间依赖性;抗组织因子抗体能够抑制HT1080的血管外游走,并且高浓度的抗TF抗体(20 mg/L)较低浓度的抗TF抗体(5 mg/L)的抑制作用更为明显,差异有显著意义(P<0.05),具有浓度依赖性。结论:组织因子能够促进纤维肉瘤细胞的血管外游走,从而加速纤维肉瘤细胞的血行转移。     

The origin of intracranial fibrosarcoma

Summary To elucidate the cellular derivation of intracranial fibrosarcoma, specimens from two cases of primary sarcoma and two cases of secondary, radiation-induced sarcoma in the cranium were examined by light and electron microscopy and histochemical techniques. The findings were carefully compared with those in four cases of benign fibroblastic meningioma. All the intracranial sarcomas examined in this study were localized on the cerebral surface and invaded the dura mater and brain.The histology of these tumors closely resembled that of fibrous fibrosarcoma described by Christensen and Lara [2]. The microscopic features of primary sarcomas were characterized by a spoke wheel arrangement of tumor cells, intercellular deposits of variable amounts of collagen fibers and the presence of many xanthoma cells. Secondary sarcomas presented tumor cells arranged in parallel interlacing bundles. An island of tumor tissue with the characteristics of benign meningioma was disclosed in a primary sarcoma. In meningioma was disclosed in a primary sarcoma. In electron micrographs, sarcoma cells showed ultrafine structures characteristic of meningothelial cells, including interdigitated cytoplasmic processes, desmosomes and/or half desmosomes, and abundant intracytoplasmic filaments. Basement membrane or an analogous substance, which is very unusual in the meningioma, were identified in some specimens of our primary sarcomas and fibroblastic meningioma. In the histochemical study, the activities of acid phosphatase and non-specific esterase showed no significant differences between the sarcoma cells and the meningioma cells.On the basis of morphological and histochemical findings, it is concluded in this study that fibrous fibrosarcomas in the cranium are of meningothelial derivation and therefore should be included in the category of malignant meningioma.     

In vivo and in vitro antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on human fibrosarcoma cells HT-1080

Current treatment of fibrosarcoma, an aggressive cancer of the connective tissue, is generally associated with poor prognosis. Matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF), and constituents of the extracellular matrix (ECM), such as fibronectin, play a critical role in angiogenesis and underlie neoplastic invasion and metastasis. This and anticancer properties of lysine, proline, arginine, ascorbic acid, and green tea extract (NM) prompted us to investigate the effect of these nutrients in vitro on human fibrosarcoma cells HT-1080 by measuring cell proliferation, modulation of MMP-2 and MMP-9, and invasive potential. In vivo, we studied the growth of human fibrosarcoma HT-1080 cells in athymic nude mice and the expression of MMPs and VEGF. Cell proliferation was evaluated by MTT assay, MMP expression by gelatinase zymography, and invasion through Matrigel and migration by scratch assay. Tumors were excised, weighed, and processed for histology in both the control and nutrient-supplemented groups. Results showed NM inhibited the growth and reduced the size of tumors in nude mice; decreased MMP-9 and VEGF secretion was found in the suplemented group tissues. NM inhibited invasion through Matrigel and migration with total inhibition at 1000 μg/mL. These results offer promise in the therapeutic use of the nutrient mixture of lysine, proline, arginine, ascorbic acid, and green tea extract tested in the treatment of fibrosarcoma.