Allopregnanolone,a GABAA receptor agonist,decreases gonadotropin levels in women. A preliminary study

Animal studies suggest regulatory effects on the hypothalamic-pituitary-gonad axis by allopregnanolone, an endogenous gamma-aminobutyric acid A (GABA_A) receptor agonist. Elevated levels of allopregnanolone in women with hypothalamic amenorrhea have been seen. Isoallopregnanolone is an isomer to allopregnanolone, but without GABA_A receptor effects. The purpose of this study was to investigate effects of allopregnanolone and isoallopregnanolone on gonadotropin levels in healthy women of fertile age. Ten women were given allopregnanolone and five women isoallopregnanolone intravenously in follicular phase. Repeated blood samples were drawn during the test day. Main outcomes were changes in serum levels of follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, and progesterone. Serum-FSH decreased between 5 and 105?min after the allopregnanolone injection (F(16,144)=2.18, p=0.008). Serum-LH was reduced between 5 and 35?min following the allopregnanolone injection (F(16,144)=2.63, p=0.001). Serum-oestradiol and -progesterone were not significantly changed after allopregnanolone injections. No effect on gonadotropin levels were seen after administration of isoallopregnanolone. Allopregnanolone reduces FSH and LH levels in women and the effect might be mediated via a specific GABA_A receptor activation since isoallopregnanolone lacked this effect. Although the number of women was small, the results suggest a regulatory mechanism on the hypothalamic-pituitary-gonadal axis by allopregnanolon.     

2,3,6,7-二苯并蒽对大鼠生殖内分泌影响的研究

目的：探讨2，3，6，7－二苯并蒽对切除卵巢大鼠生殖内分泌和子宫雌激素受体的影响。方法：应用放射免疫法（RIA）和放射配体受体法。结果：2，3，6，7－二苯并蒽在皮下注射5d后，低及高剂量均可导致切除卵巢的大鼠子宫湿重明显增加（P＜0．01），低及高剂量组大鼠子宫雌激素受体数量与对照组比，差异无显著性（P＞0．05），但高剂量组大鼠子宫雌激素受体亲和力明显高于对照组（P＜0．05）。低及高剂量组血清中卵泡刺激素（FSH）含量与对照组比，差异无显著性（P＞0．05），低及,高剂量组血清中黄体生成素（LH）含量明显降低（P＜0．01，P＜0．05），高剂量组血清中催乳素（PRL）含量明显增加（P＜0．05）。结论：2，3，6，7－二苯并蒽雌激素活性的作用机制可能是干扰下丘脑－垂体－卵巢轴对生殖内分泌的调控。     

训练对血清睾酮、皮质醇与促卵泡激素水平的影响

测定7名游泳运动员在训练期前、训练1.5个月后、训练2.5个月后的血清睾酮、皮质醇及FSH。发现:在整个训练期,血清睾酮水平呈上升趋势,而血清皮质醇、FSH水平明显下降,睾酮/皮质醇比值明显增加。     

坤泰胶囊联合唑吡坦治疗肾虚肝郁型更年期综合征睡眠障碍的疗效观察

目的 探讨坤泰胶囊联合唑吡坦治疗肾虚肝郁型更年期综合征睡眠障碍的临床效果。方法 选取2022年1月—2022年12月济宁医学院附属医院收治的120例肾虚肝郁型更年期综合征睡眠障碍患者，随机分为对照组与治疗组，每组各60例。对照组患者睡前口服酒石酸唑吡坦片，起始剂量5 mg/次，1次/d，最大剂量10 mg。治疗组在对照组基础上口服坤泰胶囊，4粒/次，3次/d。两组患者治疗12周。观察两组患者临床疗效，比较治疗前后两组患者中医证候积分和匹兹堡睡眠质量指数量表（PSQI）评分，及雌二醇（E₂）、卵泡刺激素（FSH）和促黄体生成素（LH）水平。结果 治疗后，治疗组患者总有效率较对照组显著升高（98.33% vs 88.33%，P＜0.05）。治疗后，两组患者中医证候积分及PSQI评分均显著低于治疗前（P＜0.05），且治疗组评分显著低于对照组（P＜0.05）。治疗后，两组患者FSH和LH水平显著低于治疗前，而E₂水平显著高于治疗前（P＜0.05），且治疗组患者性激素水平显著好于对照组（P＜0.05）。结论 坤泰胶囊联合唑吡坦治疗肾虚肝郁型更年期综合征睡眠障碍能有效调控患者性激素水平，改善中医证候及提高睡眠质量。     

长期停服棉酚男子血液性激素的变化

本文测定了16名长期停服棉酚男子血清FSH、LH和睾丸酮(T)的水平。停服棉酚后,精子计数为零的7名受试者,血清FSH和LH水平显著高于正常对照组;血清T略低于正常对照组,而T/LH值则显著低于正常对照组。表明睾丸功能受到不同程度的损伤。另外9名停服棉酚后,精子计数完全恢复者,除血FSH高于对照组外,其余指标与正常对照组比较均无显著性差异。提示当棉酚剂量尚未使生精过程受到不可逆性损伤时,其间质细胞的功能受损可能不大。