全文获取类型
收费全文 | 99724篇 |
免费 | 9851篇 |
国内免费 | 5161篇 |
专业分类
耳鼻咽喉 | 2226篇 |
儿科学 | 623篇 |
妇产科学 | 1720篇 |
基础医学 | 10765篇 |
口腔科学 | 3389篇 |
临床医学 | 7366篇 |
内科学 | 13320篇 |
皮肤病学 | 1981篇 |
神经病学 | 220篇 |
特种医学 | 4467篇 |
外国民族医学 | 122篇 |
外科学 | 15259篇 |
综合类 | 17422篇 |
现状与发展 | 23篇 |
预防医学 | 2306篇 |
眼科学 | 391篇 |
药学 | 5097篇 |
20篇 | |
中国医学 | 1192篇 |
肿瘤学 | 26827篇 |
出版年
2024年 | 124篇 |
2023年 | 1352篇 |
2022年 | 2323篇 |
2021年 | 3896篇 |
2020年 | 3368篇 |
2019年 | 3158篇 |
2018年 | 3039篇 |
2017年 | 3415篇 |
2016年 | 3883篇 |
2015年 | 4484篇 |
2014年 | 6755篇 |
2013年 | 5875篇 |
2012年 | 6125篇 |
2011年 | 6622篇 |
2010年 | 5355篇 |
2009年 | 5281篇 |
2008年 | 5453篇 |
2007年 | 5700篇 |
2006年 | 5329篇 |
2005年 | 4741篇 |
2004年 | 3751篇 |
2003年 | 3298篇 |
2002年 | 2796篇 |
2001年 | 2678篇 |
2000年 | 2291篇 |
1999年 | 1849篇 |
1998年 | 1692篇 |
1997年 | 1498篇 |
1996年 | 1303篇 |
1995年 | 1129篇 |
1994年 | 1006篇 |
1993年 | 707篇 |
1992年 | 624篇 |
1991年 | 540篇 |
1990年 | 462篇 |
1989年 | 404篇 |
1988年 | 386篇 |
1987年 | 314篇 |
1986年 | 250篇 |
1985年 | 272篇 |
1984年 | 227篇 |
1983年 | 155篇 |
1982年 | 181篇 |
1981年 | 161篇 |
1980年 | 146篇 |
1979年 | 116篇 |
1978年 | 88篇 |
1977年 | 58篇 |
1976年 | 46篇 |
1975年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 406 毫秒
61.
Zheyuan Wang Zhiheng Shi Lu Zhang Huihan Zhang Yawu Zhang 《Pathology, research and practice》2019,215(3):499-505
Profilin 1 (PFN1) is a critical actin-regulatory protein; however, its functional role in hepatocellular carcinoma (HCC) progression remains to be further elucidated. In the present study, we observed that the expression levels of PFN1 were significantly decreased in HCC tissues and cell lines. Low PFN1 expression was significantly correlated with aggressive clinicopathological characteristics and poor prognosis of HCC patients. Further in vitro experiments demonstrated that overexpression of PFN1 remarkably inhibited the proliferation, migration, invasion and EMT of HCC cells. Moreover, we also found that PFN1 was a direct target gene of miR-19a-3p, and in HCC tissues, and there was a significantly inverse correlation between PFN1 mRNA and miR-19a-3p expression. Collectively, our results showed that PFN1 functions as a tumor suppressor in HCC, and might serve as a diagnostic and therapeutic target for HCC patients. 相似文献
62.
63.
《Neuro-Chirurgie》2022,68(2):196-201
BackgroundTumor-to-tumor metastases are extremely rarely reported lesions, which usually involve an indolent lesion hosting a more aggressive neoplasm. We present an unusual initial manifestation of a previously unknown clear cell renal cell carcinoma as a tumor-to-tumor metastasis in a typical meningothelial meningioma.Case reportA 73-year old patient with transient left slight monoparesis was addressed to our Neurosurgical Department after being evaluated by his general practitioner and passing a cerebral MRI which revealed a right frontotemporal mass attached to the meninge. At presentation, no deficits were identified; therefore an elective surgery was proposed. Histological analysis revealed a typical meningothelial meningioma containing a metastatic clear cell renal cell carcinoma. Additional thoraco-abdominal computer tomography identified a 6 cm diameter lesion within the right kidney with radiological features highly suggestive of a primary clear cell renal cell carcinoma.ConclusionOur case highlights the need for a specialized neuropathological approach to clinical and imagistic indolent meningiomas, as they may require important differential diagnosis that can highly impact the treatment and follow-up of brain tumor patients. 相似文献
64.
I Ahmad 《Annals of the Royal College of Surgeons of England》2015,97(7):481-486
Urothelial cell carcinoma (UCC) of the bladder is one of the most common malignancies, causing considerable morbidity and mortality worldwide. It is unique among the epithelial carcinomas as two distinct pathways to tumourigenesis appear to exist: low grade, recurring papillary tumours usually contain oncogenic mutations in FGFR3 or HRAS whereas high grade, muscle invasive tumours with metastatic potential generally have defects in the pathways controlled by the tumour suppressors p53 and retinoblastoma. Over the last two decades, a number of transgenic mouse models of UCC, containing deletions or mutations of key tumour suppressor genes or oncogenes, have helped us understand the mechanisms behind tumour development. In this summary, I present my work investigating the role of the WNT signalling cascade in UCC. 相似文献
65.
《Cancer cell》2021,39(11):1497-1518.e11
66.
67.
68.
69.
Bimal Bhindi Christine M. Lohse Phillip J. Schulte Ross J. Mason John C. Cheville Stephen A. Boorjian Bradley C. Leibovich R. Houston Thompson 《European urology》2019,75(5):766-772
Background
Partial nephrectomy (PN) is generally favored for cT1 tumors over radical nephrectomy (RN) when technically feasible. However, it can be unclear whether the additional risks of PN are worth the magnitude of renal function benefit.Objective
To develop preoperative tools to predict long-term estimated glomerular filtration rate (eGFR) beyond 30 d following PN and RN, separately.Design, setting, and participants
In this retrospective cohort study, patients who underwent RN or PN for a single nonmetastatic renal tumor between 1997 and 2014 at our institution were identified. Exclusion criteria were venous tumor thrombus and preoperative eGFR <15 ml/min/1.73 m2.Intervention
RN and PN.Outcome measurements and statistical analysis
Hierarchical generalized linear mixed-effect models with backward selection of candidate preoperative features were used to predict long-term eGFR following RN and PN, separately. Predictive ability was summarized using marginal , which ranges from 0 to 1, with higher values indicating increased predictive ability.Results and limitations
The analysis included 1152 patients (13 206 eGFR observations) who underwent RN and 1920 patients (18 652 eGFR observations) who underwent PN, with mean preoperative eGFRs of 66 ml/min/1.73 m2 (standard deviation [SD] = 18) and 72 ml/min/1.73 m2 (SD = 20), respectively. The model to predict eGFR after RN included age, diabetes, preoperative eGFR, preoperative proteinuria, tumor size, time from surgery, and an interaction between time from surgery and age (marginal ). The model to predict eGFR after PN included age, presence of a solitary kidney, diabetes, hypertension, preoperative eGFR, preoperative proteinuria, surgical approach, time from surgery, and interaction terms between time from surgery and age, diabetes, preoperative eGFR, and preoperative proteinuria (marginal ). Limitations include the lack of data on renal tumor complexity and the single-center design; generalizability needs to be confirmed in external cohorts.Conclusions
We developed preoperative tools to predict renal function outcomes following RN and PN. Pending validation, these tools should be helpful for patient counseling and clinical decision-making.Patient summary
We developed models to predict kidney function outcomes after partial and radical nephrectomy based on preoperative features. This should help clinicians during patient counseling and decision-making in the management of kidney tumors. 相似文献70.