Effects of sodium and temperature on tension in isolated canine coronary artery

The effects of sodium and temperature on tension of isolated canine coronary arterial strips were studied.In 20mEq·l ^–1 K solution, the strength of tension was inversely related to the Na concentration. At 37°C, the tension was significantly increased at 70mEq·l ^–1 Na and below. The tension was gradually suppressed by lowering of the temperature from 37°C to 10°C. At 10°C, tension did not developed significantly at Na concentrations between 127mEq·l ^–1 and 12mEq·l ^–1.It was concluded that the decrease in Na concentrations increased the tension of the canine coronary artery and the lowering of temperature supressed the tension inducted by the decrease in Na concentrations.(Yoshida K, Fujii Y, Ina H, et al.: Effects of sodium and temperature on tension in isolated canine coronary artery. J Anesth 5: 56–59, 1991)     

颈内动脉—后交通动脉瘤的外科治疗：附13例报告

我院自1982年～1988年共收治13例颈内动脉-后交通动脉瘤。本文就该处动脉瘤的临床诊断、手术入路以及动脉瘤破裂的预防和处理进行了讨论。     

Effects of molsidomine and dopamine infusion on the size of canine experimental myocardial infarct

Summary The effects of i.v. molsidomine and dopamine infusion on mean haemodynamic changes, myocardial oxygen consumption (pressure-rate-product), and ultimate infarct size were studied in pentobarbital-anaesthetized, open-chest dogs and compared to those occurring in dogs receiving saline infusion. Either agent was administered in a separate setting. Haemodynamic variables and oxygen consumption were determined during a 6-h period after ligation of the left anterior descending coronary artery and collected at 1-h intervals. Infarct size was determined by post-mortem nitroblue tetrazolium stain of intracellular lactic dehydrogenase enzymes. Coronary artery ligation during saline infusion (n=8) resulted in decreased blood pressure and cardiac output, whereas heart rate, systemic peripheral resistance, end-diastolic filling pressure and myocardial oxygen consumption increased. Infarct size amounted to 24.2±3.2% (i. e., 23.8±3.1 g) of left ventricular mass. Infusion of 1.4 g/kg/min molsidomine (n=8) produced significant fall of blood pressure, cardiac output, filling pressure and oxygen consumption while heart rate and peripheral resistance were unaffected. The infarct volume was reduced to 49% (P<0.01) of that observed in saline controls. The administration of 3 g/kg/min dopamine (n=8) elevated blood pressure and cardiac output initially with a subsequent reduction of either parameter. Arteriolar vascular resistance and oxygen consumption increased but filling pressure remained unchanged. Infarct size was not different from saline controls. Infusion of 6 g/kg/min dopamine, however, significantly increased blood pressure, heart rate, and peripheral resistance. Cardiac output and filling pressure fell and myocardial oxygen consumption rose. The histochemically measured final infarct was reduced to 13.5±1.8% of left ventricle (i. e., 16.2±2.2 g, P<0.05 vs saline control), but the hearts were edematous and haemorrhagic. Therapy with molsidomine appears promising in the treatment of clinical myocardial infarction with haemodynamic sequellae. The safe use of therapy with higher dopamine doses in patients with acute myocardial infarction, however, awaits further investigation.Part of the dopamine experiments were done at Bayer AG, Institut für Pharmakologie     

Unusual fractures and dislocations of the axis vertebra

Seven percent of 400 patients with cervical spine fractures and/or dislocations had unusual lesions of the axis. The authors have analyzed axis injuries by review of radiographs and clinical data and have derived a classification of traumatic conditions. Uncommon traumatic axis abnormalities are discussed with reference to incidence, causes, clinical findings, mechanism of injury, and roentgen characteristics.Picker Scholar, James Picker Foundation     

妇科晚期恶性肿瘤超选择动脉插管化疗

目的 探讨治疗妇科晚期恶性肿瘤的方法。方法 采用Scldinger法作超选择髂内动脉插管化疗(SIAC)，治疗妇科晚期恶性肿瘤73例，其中22例伴有腹水，2例伴有胸水。结果 22例腹水、胸水患者，经SIAC治疗后，腹水基本吸收及明显减少20例，占99％，自觉症状(腹痛、腹胀、下坠等)较前明显好转。介入化疗后术中见肿瘤体积缩小，粘连程度减轻，术中出血少，行宫颈癌根治术41例，行卵巢癌根治术10例。结论 超选择动脉插管化疗治疗妇科晚期恶性肿瘤有效可行。     

颈椎关节突交锁的诊断与外科治疗

本文报告从1991年12月至2001年12月诊治的14例陈旧性颈椎关节突交锁患者,受伤至入院时间平均3.9个月(1～10个月)。脱位节段:C_(3～4) 2例,C_(4～5)4例,C_(5～6)5例,C_(6～7)3例。单侧脱位9例,双侧脱位5例。本组患者均有被误诊、误治的病史。在交锁关节突切除,脱位节段植骨融合的基础上,分别采用4种复位固定方法。术后随访平均2年8个月(6个月～5年3个月),9例患者中有7例神经症状有不同程度的改善。本文还对该病的诊断要点,误诊误治原因及目前的处理观点等问题作了讨论。     

中药内服配合手法治疗椎动脉型颈椎病疗效观察

目的：观察中药内服加手法治疗椎动脉型颈椎病的临床疗效。方法：取椎动脉型颈椎病患者200例，随机分为观察组和对照组，人别给予中药内服加手法和牵引治疗，观察比较两组疗效。结果：观察组治愈率76％，总有效率92％；对照组治愈率50％，总有效率68％二者经统计学处理，有显著差异。结论：中药内服配合手法治疗椎动脉型颈椎病疗效优于单纯牵引治疗。     

康莱特联合化学药物动脉灌注治疗转移性肝癌的临床研究

目的：观察康莱特联合化学药物动脉灌注治疗转移性肝癌的疗效。方法：152例转移性肝癌患者随机分为治疗组(康莱特联合化学药物动脉灌注)79例、对照组(化学药物动脉灌注)73例。结果：治疗组的稳定率为87．3％，1年生存率为73．4％，2年生存率为50．6％，均明显高于对照组；并可减低血液高凝状态，提高患者的细胞免疫功能，缓解化疗药物的毒副反应，改善患者的生活质量。结论：康莱特联合化学药物动脉灌注治疗转移性肝癌有较好的疗效。     

中国小型猪心导管介入冠状动脉栓塞心肌梗塞模型的建立

目的 建立中国小型猪心导管介入冠状动脉栓塞心肌梗塞模型，为基础医药学研究尤其为干细胞移植治疗冠心病研究提供新的方法。方法与结果 选用心脏及冠状动脉系统的解剖生理特点与人相似的中国小型猪，应用心导管介入技术将栓子定位植入冠状动脉，阻断冠状动脉血流，造成心肌梗塞，形成与临床相似的病理生理过程，从而建立了普遍适用于急性与慢性实验研究的中国小型猪心肌梗塞模型。结论 该模型稳定，方法先进，可进行准确的定位、定量、动态观测，结果可靠，重复性好，可广泛用于药理学、病理生理学以及细胞工程学等各个领域的研究。