C反应蛋白检测与临床应用

C-反应蛋白（c—reactive protein，CRP）于1930年由Tillett和Frsncis首先发现，他们观察到一些病人的血清能和肺炎链球菌荚膜C-多糖物质c—polysaccharide substrate，CPS），在钙离子存在下形成复合物，产生沉淀反应并将其命名为C-反应素。1941年经Avery测定后确认在血清中形成沉淀反应抟是一种蛋白质．即将其定名为C-反应蛋白。     

湿润烧伤膏治疗16例褥疮的护理体会

褥疮不仅由压力引起，而且也可以由摩擦力和剪切力引起，通常由2—3种力联合作用所致。褥疮的防治是临床护理中的难题之一。高位截瘫、昏迷、晚期癌症等其他危重长期卧床患者，由于长期卧床、感觉障碍、局部皮肤及全身营养状况差、大小便失禁等因素，褥疮的发生率提高。既增加了患者的痛苦，又延长了住院时间。过去普遍认为创面干燥清洁有利于褥疮愈合。最近，通过临床观察，湿润更有利于创面上皮细胞的形成，使创面不经过一般的结痂过程而自然愈合。笔者通过使用湿润烧伤膏治疗湿敷创面，结合营养补充、预防感染、心理护理等，特别是对Ⅲ、Ⅳ度褥疮取得了满意疗效。操作简便易行，见效快，现介绍如下。     

从右下腹痛谈对实习医生临床诊断能力的培养

以右下腹痛待诊的病人为例,探讨如何培养实习医生临床诊治病人的思维能力。其正确的临床思维必须来自扎实的基础和临床理论知识,仔细的询问病史和一丝不苟的体格检查,严密的逻辑思考和不断的经验教训总结。学生临床思维能力的培养和提高除了理论指导外,更重要的是重视临床教学实践。     

三七在临床急症的应用

三七具有散瘀止血、消肿定痛的功效。临床上用途广泛，疗效显著，对人体心、脑血管系统、消化系统、神经系统、免疫系统等都有显著的作用。本文对其在临床急症方面的应用作初步的总结，探讨其作用的机理。     

60例牙周炎中西医结合治疗临床观察

牙周炎归属中医牙疳的范畴，笔者用中药加抗生素治疗收到显著的疗效，现报道如下。     

自制复合液治疗偏头痛148例疗效分析

偏头痛在临床上是一种常见病,传统的中、西药治疗虽能取得一定疗效,但显效慢,服药时间长,且复发率高.我们对148例有典型血管神经性偏头痛症状者,采用2种复合液治疗,观察其疗效、疗程,旨在探讨有效的治疗方法.     

左旋布比卡因腰麻用于剖宫产术的临床观察

我科白2005年8月至2006年4月应用0．75％左旋布比卡因腰麻行剖宫产手术30例，效果良好，报道如下。     

咽喉结核9例误诊临床分析

为提高对本病的诊疗水平,现将我科门诊1997年1月~2002年12月诊治的咽结核9例,采用回顾性调查的方法,对其临床资料进行分析讨论。现报告如下。资料与方法咽喉结核患者9例,男3例,女6例,年龄24~64岁,平均46.5岁,病程1~6个月,其中咽结核4例,喉结核5例,6例由外院按非特异性炎症治疗无效转来我院,3例在我院误诊。咽及扁桃体结核4例,均以咽部异物感为主,偶伴咽痛,全身中毒不明显。2例误诊为“奋森咽峡炎”,经抗炎及抗病毒治疗7天~2周,疗效差,检查见咽腔黏膜弥漫性充血,黏膜粗糙,鄂弓及咽侧索有散在溃疡及少量肉芽,经过1~2次活检确诊。2例表现为单侧…     

表达谱基因芯片筛选体外循环前后心肌细胞因子的变化

Objestive Systemic inflarmmation may be triggered by injury, hypothermia, ischemia-reperfusion and the contact of the blood with foreign body during cardiopulmonary bypass (CPB). To determine the application values of gene chip technique in the clinical practice and the study of cardiovascular stagery, as well as to provide clues to the study of inflammatory responess during CPB, microarry for gene expression profiles was used to identify the differences in the gene expression of myocardium between pre-and post- CPB. Methods Six adult patients who underwent CPB from March to May in 2003 were involved. Samples of right atrium were col- lected before and at immediate end of CPB. BD AtlasTM cDNA Expression Arrays was used to identify the differences in the gene ex- pression of cytokines. The results were compared with that of semi-quantative RT-PCR. Resellts The mean age of 6 patients (5 males and 1 female) was (32.67± 11.72) years. The baseline heart function was gradeⅡin 3 cases and grade Ⅲ in 3 other cases. The baseline left ventricular ejection fraction(LVEF)was (58.17±7.91)%. The mere duration was (91.67±43.88) minutes for CPB and was (58.67±43.46) minutes for aorta blocking. The minimum nasopharynx/rectal temperture was (29.37±1.90)℃/ (32.15±1.52)℃. Gene expression profiles of cytokines in the myocardium pre- and post-CPB were analysed successfully. The ex- pression of IL-6, IFN-γ,Wnt5a, TNFRSF1B, a member of tumor necrosis factor receptor superfamily, PIGF and MFNG in the myo- cardium were unpregulated after CPB. Conclusion Microarray technique is applicable in the study of cytokines changes dying CPB. cDNA microarray identified pleliminarily the differences in the gene expression between pre- and post-CPB. These genes may be in- valved in inflammation and other psthophysiological responses incuced by CPB. The myocardiym is probably one of the major sources of cytokines during CPB. Further study may be helpful in understanding the llngthe development of inflammation during CPB, and eventually, reducing the post-operative complications.     

剖宫产术后并发下肢静脉栓塞的护理及预防

通过对20例剖宫产术后并发下肢静脉栓塞病人的观察,分析了发生静脉栓塞的原因,提出了相应的护理、观察、预防等一系列措施.