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11.
目的探讨应用邻指皮瓣联合同指侧方带蒂皮瓣治疗手指近节指间关节严重屈曲挛缩畸形的临床疗效。方法 2008年10月-2011年2月,收治11例11指手指近节指间关节严重屈曲挛缩患者。男7例,女4例;年龄20~63岁,平均32.6岁。挤压伤及电锯伤7例,烧伤及爆炸伤3例,电击伤1例。指别:示指4例,中指2例,环指2例,小指3例。病程6~24个月,平均12.4个月。按照Stern等手指近节指间关节挛缩分型标准,均为Ⅲ型。术中切除瘢痕后,手指伸直掌侧皮肤软组织缺损范围3.0 cm×1.5 cm~5.0 cm×2.5 cm,均伴肌腱、神经、血管或指骨外露。采用大小为2.2 cm×1.8 cm~3.8 cm×2.5 cm的邻指皮瓣联合大小为1.5 cm×1.2 cm~2.5 cm×2.0 cm的患指侧方带蒂皮瓣移位修复,其中3例采用2个指侧方带蒂皮瓣。供区植皮或直接拉拢缝合。结果术后皮瓣及植皮均成活,创面Ⅰ期愈合。患者均获随访,随访时间6~18个月,平均11.3个月。患指外形恢复满意,皮瓣质地柔软,无明显色素沉着及瘢痕挛缩。患指均可完全伸直,患指主、被动屈伸活动恢复满意。末次随访时,近节指间关节最大伸直角度范围10~15°,按照中华医学会近节指间关节活动范围标准评定:优6例,良4例,可1例,优良率为90.9%。结论邻指皮瓣联合同指侧方带蒂皮瓣具有操作简便、修复面积大、术后外观及功能恢复满意的优点,是治疗手指近节指间关节严重屈曲挛缩畸形较理想方法之一。 相似文献
12.
Fischer T Wigger-Alberti W Elsner P 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》1999,50(1):5-11
Melatonin (N-acetyl-5-methoxytryptamine) is a hormone with multiple functions in humans, produced by the pineal gland and stimulated by beta-adrenergic receptors. Serum melatonin levels exhibit a circadian rhythm with low levels during the day, rise in the evening and maximum levels at night between 2 and 4 a.m. Melatonin participates in the regulation of several physiological processes such as seasonal biological rhythm, daily sleep induction, aging and modulation of immunobiological defence reactions. Furthermore, melatonin has a highly lipophilic molecular structure facilitating penetration of cell membranes and serving as an extra- and intracellular free radical scavenger. Melatonin seems to quench mainly hydroxyl radicals, the most damaging of all free radicals. Melatonin may play a role in the etiology and treatment of several dermatoses e.g. atopic eczema, psoriasis and malignant melanoma. The influence of melatonin on hair growth is another aspect. Topical application of melatonin inhibits the development of UV-erythema. Penetration through skin after topical application and oral bioavailability auxit further investigations on the pharmacokinetic and pharmacodynamic actions of melatonin. 相似文献