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51.
52.
肝细胞生长因子对多囊肾病囊肿衬里上皮细胞增殖及细胞外基质合成的影响 总被引:2,自引:2,他引:0
目的:研究重组人肝细胞生长因子(rhHGF)对常染色体显性遗传型多囊肾病(ADPKD)囊肿衬里上皮细胞增殖及细胞外基质合成的影响。方法:用^3H-TdR掺入法测定不同浓度(0.5、1、2.5、5ng/ml)rhHGF作用48h以及最适浓度的rhHGF分别作用24、48、72h ADPKD囊肿衬里上皮细胞系细胞的增殖情况;并分别用^3H-脯氨酸掺入法和放免法测定最适浓度rhHGF作用最佳时间后ADPKD囊肿衬里上皮细胞系细胞胶原及层粘连蛋白的合成情况。结果:rhHGF促进了ADPKD囊肿衬里上皮细胞增殖及胶原和层粘连蛋白的合成,以1ng/ml持续作用48h最为显。结论:rhHGF对体外培养的ADPKD囊肿衬里上皮细胞增殖及细胞外基质合成有明显的促进作用。 相似文献
53.
R. J. H. Ensink P. L. M. Huygen P. Van Hauwe P Coucke C. W. R. J. Cremers G. Van Camp 《European archives of oto-rhino-laryngology》2000,257(2):62-67
We studied a Dutch family with DFNA2-linked progressive sensorineural hearing impairment (SNHI). Recent audiograms were obtained
from 18 of the affected persons (age 7–81 years) and were used in a gene-linkage analysis. Linear regression analysis of the
audiograms, using binaural mean thresholds, disclosed on average a descending slope of approximately 10 dB/octave at any age
and an annual threshold increase at any frequency of about 0.7 dB/year. There may have been substantial congenital impairment
at higher frequencies, but longitudinal analysis of hearing impairment in the youngest case, who was followed from age 5 years,
suggested that the most significant changes in hearing may have occurred in the first two decades of life. Linkage analysis
was carried out with special attention to the DFNA2 region because hearing trends were very similar to families previously
linked to DFNA2. Linkage to DFNA2 was established with maximum lod scores of 4.7 and 3.2 for the flanking markers of the DFNA2
region (D1S432;MYCL1).
Received: 25 February 1999 / Accepted: 11 June 1999 相似文献
54.
Summary Hyperextensibility of the proximal interphalangeal joints was noted in 3 males and 6 females in 3 generations of a Japanese family. The proposita, a 14-year-old girl, had hyperextensible proximal interphalangeal joints of the 2nd, 3rd, 4th, and 5th fingers giving swan-neck appearance during the extension. She was asymptomatic and had no other features of skin involvement. Her father, younger sister, grandmother, two aunts, and three cousins on the father's side had hyperextensible proximal interphalangeal joints. No instance of male to male transmission was present. The condition was thus inherited as an autosomal or X-linked dominant trait. 相似文献
55.
Summary The study of the ultrastructure of the sural nerve and peripheral blood lymphocytes of a boy with late-infantile neuronal ceroid-lipofuscinosis revealed the presence of curvilinear bodies and fingerprint profiles. The elder sister of the patient died at the age of 7 years after progressive mental and motor deterioration. The same kind of cytoplasmic inclusions was found in the lymphocytes of the father of these children, who had had epilepsy since the age of 32. Clinical data and the results of the ultrastructural study suggest that in the same family two different forms of ceroid-lipofuscinosis appear and that the disease is inherited as an autosomal dominant trait. This family seems to suggest the nosological unity of clinically different forms of ceroid-lipofuscinosis.This work was supported by AMDA grant 1979–1980 相似文献
56.
P. Khoubesserian D. Baleriaux D. Toussaint N. Telerman-Toppet C. Coërs 《Journal of neurology》1981,226(3):157-168
Summary A 32-year-old patient had marked reduction of visual acuity due to falciform folds of the retina and retinal detachment, and severe neurological abnormality: bilateral pyramidal involvement, fasciculation in all limbs and gait ataxia. Skull radiographs showed internal frontal hyperostosis; CT scan showed calcification of the falx cerebri, and multiple arachnoid cysts were shown by myelography. A naevoid lesion had previously been removed from the left forearm. There was a history of ophthalmological symptoms in the mother and the daughter of the propositus. His son has café au lait spot on the abdomen and dentigerous cysts. The diagnosis of an adult form of basal cell naevus syndrome with an autosomal dominant mode of inheritance is discussed.This work was supported by grants from the F.R.S.M. of Belgium no. 3.4543.77 (Prof. P. Danis) and no. 3.4538.76 (Prof. C. Coërs) and the Free University of Brussels 相似文献
57.
MRI of the intraorbital optic nerve in patients with autosomal dominant optic atrophy 总被引:3,自引:0,他引:3
Votruba M Leary S Losseff N Bhattacharya SS Moore AT Miller DH Moseley IF 《Neuroradiology》2000,42(3):180-183
Measurements of the intraorbital optic nerve were made using high-resolution coronal MRI in 10 adults with autosomal dominant
optic atrophy. Comparisons were made with previous studies of 10 normal adult subjects. The cross-sectional diameters of the
optic nerve and the perineural subarachnoid space were measured and a ratio of there diameters at anterior, mid and posterior
positions along the optic nerve was determined. We found a statistically significant difference in the mean optic nerve: sheath
ratio between the control group and patients with autosomal dominant optic atrophy. At anterior, mid and posterior locations
along the optic nerve it is significantly smaller in patients with optic atrophy. We have demonstrated that the loss of ganglion
cells, previously documented in dominant optic atrophy, is associated with a significant loss of optic nerve tissue and thinning
of the nerve along its length.
Received: 6 July 1999/Accepted: 22 July 1999 相似文献
58.
Diagnosing CADASIL using MRI: evidence from families with known mutations of Notch 3 gene 总被引:4,自引:1,他引:3
Clinical data and MRI findings are presented on 18 subjects from two families with neuropathologically confirmed CADASIL.
DNA analysis revealed mutations in exon 4 of Notch 3 gene in both families. All family members with mutations in Notch 3 gene
had extensive abnormalities on MRI, principally lesions in the white matter of the frontal lobes and in the external capsules.
Of several family members in whom a diagnosis of CADASIL was suspected on the basis of minor symptoms, one had MRI changes
consistent with CADASIL; none of these cases carried a mutation in the Notch 3 gene. MRI and clinical features that may alert
the radiologist to the diagnosis of CADASIL are reviewed. However, a wide differential diagnosis exists for the MRI appearances
of CADASIL, including multiple sclerosis and small-vessel disease secondary to hypertension. The definitive diagnosis cannot
be made on MRI alone and requires additional evidence, where available, from a positive family history and by screening DNA
for mutations of Notch 3 gene.
Received: 17 February 1999 Accepted: 23 July 1999 相似文献
59.
PURPOSE: We evaluate the role of contemporary urological intervention in patients with nephrolithiasis associated with autosomal dominant polycystic kidney disease. MATERIALS AND METHODS: Intervention for upper tract stones associated with autosomal dominant polycystic kidney disease was performed in 5 women and 2 men 29 to 65 years old (mean age 47). Indications for intervention consisted of flank pain in 6 patients and/or hematuria in 2. A total of 12 procedures (mean 1.7 per patient) were performed, including shock wave lithotripsy in 6 patients, percutaneous nephrolithotomy in 2, retrograde endoscopy or manipulation in 3 and extended pyelonephrolithotomy in 1. RESULTS: All patients were rendered stone-free or had only residual "dust." Hospital stay for 5 patients was 1 night or less and there were no complications. Renal function for each patient was stable or improved as measured by serum creatinine. CONCLUSIONS: Most patients with autosomal dominant polycystic kidney disease who require intervention for nephrolithiasis can be safely and effectively treated with essentially any or all contemporary, minimally invasive techniques. The choice of intervention can be based primarily on size and location of the upper tract stones rather than the associated presence of polycystic kidneys. 相似文献
60.
先天性广泛眼外肌纤维化综合征一家系临床表型及基因连锁定位分析 总被引:1,自引:0,他引:1
目的 分析一个先天性广泛眼外肌纤维化综合征(CFEOM)家系的临床表型,并通过连锁分析方法来定位该家系的致病基因。方法 对家系中的所有患者进行临床检查。根据目前已知的两种常染色体显性遗传类型的CFEOM的遗传学位点12p11.2-q12(FEOM1)和16q24(FEOM3)选取微卫星进行连锁分析研究。结果 家系中4名患者具有典型的CFEOM表现。连锁分析显示,微卫星D12S59、D12S1048、D12S1648在所有患者中与疾病呈现共分离现象,其中D12S1048最大Lod值为1.91,而在微卫星D12S61和D12S1090处出现重组,表明该家系的致病基因位于这两个微卫星之间。结论此家系属常染色体显性遗传的CFEOM 1型,其致病基因定位于12p11.2-q12的D12S61和D12S1090之间。 相似文献