全文获取类型
收费全文 | 15654篇 |
免费 | 1880篇 |
国内免费 | 374篇 |
专业分类
耳鼻咽喉 | 236篇 |
儿科学 | 330篇 |
妇产科学 | 134篇 |
基础医学 | 967篇 |
口腔科学 | 199篇 |
临床医学 | 1047篇 |
内科学 | 1126篇 |
皮肤病学 | 557篇 |
神经病学 | 654篇 |
特种医学 | 2386篇 |
外国民族医学 | 15篇 |
外科学 | 1440篇 |
综合类 | 1836篇 |
现状与发展 | 1篇 |
预防医学 | 1259篇 |
眼科学 | 201篇 |
药学 | 754篇 |
4篇 | |
中国医学 | 308篇 |
肿瘤学 | 4454篇 |
出版年
2024年 | 34篇 |
2023年 | 221篇 |
2022年 | 417篇 |
2021年 | 626篇 |
2020年 | 515篇 |
2019年 | 528篇 |
2018年 | 561篇 |
2017年 | 549篇 |
2016年 | 695篇 |
2015年 | 724篇 |
2014年 | 1171篇 |
2013年 | 1458篇 |
2012年 | 1021篇 |
2011年 | 1006篇 |
2010年 | 741篇 |
2009年 | 713篇 |
2008年 | 700篇 |
2007年 | 670篇 |
2006年 | 650篇 |
2005年 | 604篇 |
2004年 | 488篇 |
2003年 | 458篇 |
2002年 | 385篇 |
2001年 | 360篇 |
2000年 | 276篇 |
1999年 | 252篇 |
1998年 | 239篇 |
1997年 | 212篇 |
1996年 | 221篇 |
1995年 | 143篇 |
1994年 | 119篇 |
1993年 | 109篇 |
1992年 | 92篇 |
1991年 | 106篇 |
1990年 | 85篇 |
1989年 | 102篇 |
1988年 | 85篇 |
1987年 | 75篇 |
1986年 | 65篇 |
1985年 | 87篇 |
1984年 | 62篇 |
1983年 | 57篇 |
1982年 | 44篇 |
1981年 | 34篇 |
1980年 | 42篇 |
1979年 | 33篇 |
1978年 | 15篇 |
1977年 | 18篇 |
1976年 | 19篇 |
1975年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
21.
伽玛刀治疗垂体大腺瘤临床分析(附30例报告) 总被引:2,自引:0,他引:2
目的 研究伽玛刀治疗垂体大腺瘤的效果及影响疗效的因素。方法 30例垂体大腺瘤病人用1.0T磁共振定位,Gamma-plan计划系统规划,等剂量曲线45%~60%(平均49.7%),周边剂量12~35Gy(平均22.9Gy),中心剂量24~70Gy(平均45.4Gy).Leksell伽玛刀实施放射外科治疗。分析治疗后垂体大腺瘤病例,总结其疗效和影响疗效的因素。结果 随访12~60个月,平均28个月,肿瘤完全消失6例(20%),肿瘤缩小19例(63.3%),无变化5例(16.7%);19/20(95.5%)功能性垂体腺瘤内分泌症状改善,临床症状好转,1例过早绝经(年龄36岁);5/10(50%)无功能性垂体腺瘤体积缩小.症状改善。结论 伽玛刀对于垂体大腺瘤仍是一种有效的治疗方法,其疗神与腺瘤的举类型、体积、照射剂量、剂量体剂、MRI信号特征密切相姜。 相似文献
22.
伽玛刀治疗功能性垂体瘤初步报告 总被引:1,自引:1,他引:0
目的 对伽玛刀治疗分泌型垂体瘤的疗效和并发症发生的相关因素进行探讨。方法 1997年9月至2001年11月,248例垂体瘤经伽玛刀治疗。其中.73例年龄在16至61岁的分泌型垂体瘤获得详细随访,53例为PRL型,11例GH型,2例为ACTH型,6例为PRL合并GH型,1例为PRL合并ACTH型。7例为术后复发和残留。23例曾接受过嗅隐亭治疗。平均肿瘤容积为5.83cm^3(0.14~25.20cm^3)。边缘剂量为8~35Gy。结果 平均随访时间21个月。36例(49.3%)内分泌恢复正常。内分泌恢复正常的比率3个月后1.4%,6个月后16.4%.1年后45.2%,2年后49.3%。3例(4、1%)发生垂体瘤功能低下。1例复发二次治疗。无病例发生视路受损。结论 伽玛刀治疗分泌型垂体瘤是安全有效的治疗方法。其长期疗效和并发症的发生仍需进一步的随访观察。 相似文献
23.
ISAO HARA SATOKO HIKOSAKA HIROSHI ETO HIDEAKI MIYAKE YUJI YAMADA TOSHINORI SOEJIMA KAZURO SUGIMURA SADAO KAMIDONO 《International journal of urology》2004,11(8):678-682
We report on two cases of women with locally advanced squamous cell carcinoma of the urethra. Patient 1 also displayed regional lymph node metastasis. Treatment comprised combined radiotherapy to 60 Gy and chemotherapy with 5-fluorouracil and cisplatin. Complete response was obtained in both patients, including the inguinal lymph nodes of Patient 1. Patient 1 experienced recurrent inguinal lymph node metastasis on the contralateral side at 42 months after initial treatment, and the same treatment was performed followed by surgical excision. Both patients remain alive with no evidence of disease, at 12 months after recurrence in Patient 1, and at 27 months after treatment in Patient 2. 相似文献
24.
25.
5名电离辐射事故患者外周血T细胞T细胞抗原受体、T细胞分化抗原决定簇-3效应的研究 总被引:1,自引:0,他引:1
文中报道了5名事故性急性骨髓型放射病患者照后2.5和3.5年外周血T淋巴细胞T细胞受体(TCR)基因,TCR、T细胞分化抗原决定簇-3(CD_3)表达与TCR/CD_3复合物功能的辐射效应.发现5名患者于照后2.5年,2名(5.2Gy和2.4Gy,55岁)于照后3.5年外周血T细胞应答抗CD3单抗刺激而增殖的能力尚未完全恢复;经同时用IL-2和抗CD_3单抗刺激,增殖能力比单用抗CD_3单抗刺激有所增强;后2名的外周血TCR、CD_3阳性细胞百分率一直低于正常对照和其他患者;并见一患者出现DNA重排杂交带型.本文并从TCR/CD_3在介导T细胞抗原刺激反应中的作用,电离辐射对TCR/CD_3复合物的影响,后果和意义等方面进行了讨论. 相似文献
26.
Iodine-125 interstitial irradiation for cerebral gliomas 总被引:3,自引:0,他引:3
27.
28.
Dr C. J. Whitters T. W. Macfarlane D. Mackenzie H. Moseley R. Strang 《Lasers in medical science》1994,9(4):297-303
Pulsed Nd-YAG laser irradiation of bacteria has been suggested as a possible means of treating contaminated intra-oral sites
although relatively few studies have been conducted. In this investigation, the antimicrobial activity of a pulsed Nd-YAG
laser was assessed in vitro for a range of oral bacteria using several pulse energies and exposure durations. Pure cultures
of each organism were lased in saline suspensions followed by standard colony counting techniques for test and control samples.
Microbial inhibition was found to be organism-dependent and varied with energy dose and pulse energy. For all nine test species
120-mJ laser pulses proved more efficient than 80-mJ pulses, with 99.9% kills compared with around 90% kills after exposure
to 1800 pulses. These killing activity levels compare favourably with those achieved with other lasers in vitro. 相似文献
29.
Y. SUZUKI† T. NAKANO† T. OHNO† S. KATO Y. NIIBE S. MORITA & H. TSUJII 《International journal of gynecological cancer》2006,16(1):306-311
The presence of hypoxic cells is one of the major factors affecting resistance against radiation therapy. In the clinical setting, little information exists as to the relationship between intratumoral oxygen partial pressure (pO(2)) and outcome. This study involved 30 consecutive patients with cervical cancer, who were treated with a combination of external and high-dose rate intracavitary irradiation. The pO(2) was measured before radiation therapy and at 9 Gy, using a needle-type polarographic oxygen electrode. The mean intratumoral pO(2) before radiation therapy was 17.3 +/- 10.8 mm Hg. The 3-year local control rates of patients with pO(2)< or = 20 mm Hg and pO(2) > 20 mm Hg before radiation therapy were 52% and 100%, respectively, representing a significant difference (P= 0.035). At 9 Gy, mean intratumoral pO(2) was 23.6 +/- 9.1 mm Hg, a significant increase compared to the value before radiation therapy (P= 0.006). The 3-year local control rates of tumors with pO(2)< or = 20 mm Hg and pO(2) > 20 mm Hg at 9 Gy were 35% and 93%, respectively, representing a significant difference (P= 0.001). The significantly better local control for oxygenated tumors at 9 Gy as well as before radiation therapy indicated that the oxygen effect and reoxygenation by radiation played an important role in local control in radiation therapy for cervical cancer. 相似文献
30.
R Rupprecht A Lippold C Auras G Bramkamp C Breitkopf H-J Elsmann EM Habenicht V Jasnoch H Müller-Pannes K-W Schulte L Suter 《Journal of the European Academy of Dermatology and Venereology》2007,21(2):178-185
Background Cosmetic changes are to be expected after radiotherapy for skin tumours. Objectives This study aimed to answer the questions: How frequent are cosmetic changes after soft X‐ray therapy? Do treatment parameters, tumour thickness, localization and size of the irradiated field have a major influence? Were patients irritated by the visual appearance of the irradiated field? Methods In total, 2474 examinations of 1149 irradiated fields were performed. Results Hypopigmentation was found in 64.7% of examinations more than 90 days after therapy, teleangiectases in 43.1%, erythema in 24.8%, and hyperpigmentation in 16.8%. The frequency of hypopigmentation, teleangiectases and hyperpigmentation increased with time from X‐ray exposure; more than 4 years after therapy hypopigmentation was diagnosed in 91.8% and teleangiectases in 82.2% of examinations. Total dose, the time–dose–fractionation factor (TDF), field size and dose per fraction were significantly related to the frequency of cosmetic changes. Incidence rates of cosmetic changes differed by less than 15% if different treatment conditions were compared: thicker vs. thinner tumours, larger vs. smaller fields, higher vs. lower total doses, doses per fraction, and TDF. Frequencies of hypopigmentation, teleangiectases, erythema and hyperpigmentation differed by more than 15% between some localizations on the head. Women reported irritation by the visual appearance of the irradiated field in 12.6% of 1116 interviews, and men in 4.4% of 1284 interviews. Conclusions Cosmetic changes after soft X‐ray therapy are relatively frequent. Treatment parameters, tumour thickness and field size have only a minor influence. Few patients, but more women than men, were irritated by the visual appearance of the irradiated field. 相似文献