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561.
Kurimoto R Ishii R Canuet L Ikezawa K Azechi M Iwase M Yoshida T Kazui H Yoshimine T Takeda M 《Neuroscience letters》2008,443(2):86-89
In patients with Alzheimer's disease (AD), it is sometimes challenging to identify typical findings in electroencephalography (EEG) or magnetoencephalography (MEG) such as a slowing of the posterior dominant activity or an increase in slow activity. In this MEG study, we evaluated the event-related synchronization (ERS) of alpha activity after eye closing in patients with early AD and mild cognitive impairment (MCI) who presented no slow MEG pattern. Thirteen patients with probable AD and thirteen patients with MCI, who met NINCDS-ADRDA and Petersen's diagnostic criteria, respectively, were enrolled. We also selected fourteen age-matched normal control subjects. MEG activity was acquired during eye-open and eye-closed states. The ERS after eye closing within 8-15Hz frequency band was calculated and its cortical source was superimposed on the individual's MRI by using the beamformer implemented in Brain Electrical Source Analysis (BESA). The Source image was converted into a standardized image, and group comparisons across patients with AD, MCI and controls were performed using BrainVoyager QX. The averaged ERS was observed dominantly in posterior regions in all three groups. Significant difference in ERS was observed only for the comparison between AD patients and controls, with AD patients showing increased ERS in frontal regions. Frontal shift of posterior alpha activity was observed clearly in AD patients using the combination of beamformer and group comparison. 相似文献
562.
Edgar JC Hanlon FM Huang MX Weisend MP Thoma RJ Carpenter B Hoechstetter K Cañive JM Miller GA 《Psychophysiology》2008,45(5):812-824
Considerable evidence indicates early auditory stimulus processing abnormalities in schizophrenia, but the mechanisms are unclear. The present study examined oscillatory phenomena during a paired-click paradigm in the superior temporal gyrus (STG) as a possible core problem. The primary question addressed is whether first click and/or second click group differences in the time-domain evoked response in patients with schizophrenia are due to (1) group differences in the magnitude of poststimulus oscillatory activity, (2) group differences in poststimulus phase-locking, and/or (3) group differences in the magnitude of ongoing background oscillatory activity. Dense-array magnetoencephalography from 45 controls and 45 patients with schizophrenia produced left- and right-hemisphere STG 50- and 100-ms time-frequency evoked, phase-locking, and total power measures. Whereas first click 100-ms evoked theta and alpha abnormalities were observed bilaterally, evoked low beta-band differences were specific to the left hemisphere. Compared to controls, patients with schizophrenia showed more low-frequency phase variability, and the decreased 100-ms S1 evoked response observed in patients was best predicted by the STG phase-locking measure. 相似文献
563.
Junpei Tanigawa Kuriko Kagitani-Shimono Junko Matsuzaki Rei Ogawa Ryuzo Hanaie Tomoka Yamamoto Koji Tominaga Shin Nabatame Ikuko Mohri Masako Taniike Keiichi Ozono 《Clinical neurophysiology》2018,129(9):2029-2037
Objective
Individuals with autism spectrum disorder (ASD) often show characteristic differences in auditory processing. To clarify the mechanisms underlying communication impairment in ASD, we examined auditory language processing with both anatomical and functional methods.Methods
We assessed the language abilities of adolescents with ASD and typically developing (TD) adolescents, and analyzed the surface-based morphometric structure between the groups using magnetic resonance imaging. Furthermore, we measured cortical responses to an auditory word comprehension task with magnetoencephalography and performed network-based statistics using the phase locking values.Results
We observed no structural differences between the groups. However, the volume of the left ventral central sulcus (vCS) showed a significant correlation with linguistic scores in ASD. Moreover, adolescents with ASD showed weaker cortical activation in the left vCS and superior temporal sulcus. Furthermore, these regions showed differential correlations with linguistic scores between the groups. Moreover, the ASD group had an atypical gamma band (25–40?Hz) network centered on the left vCS.Conclusions
Adolescents with ASD showed atypical responses on the auditory word comprehension task and functional brain differences.Significance
Our results suggest that phonological processing and gamma band cortical activity play a critical role in auditory language processing-related pathophysiology in adolescents with ASD. 相似文献564.
《Clinical neurophysiology》2020,131(2):425-436
ObjectiveVisual inspection of interictal epileptiform discharges (IEDs) in multi-channel MEG requires a time-consuming evaluation process and often leads to inconsistent results due to variability of IED waveforms. Here, we propose a novel extraction method for IEDs using a T/k type of blind source separation (BSST/k).MethodsWe applied BSST/k with seven patients with focal epilepsy to test the accuracy of identification of IEDs. We conducted comparisons of the results of BSS components with those obtained by visual inspection in sensor-space analysis.ResultsBSST/k provided better signal estimation of IEDs compared with sensor-space analysis. Importantly, BSST/k was able to uncover IEDs that could not be detected by visual inspection. Furthermore, IED components were clearly extracted while preserving spike and wave morphology. Variable IED waveforms were decomposed into one dominant component.ConclusionsBSST/k was able to visualize the spreading signals over multiple channels into a single component from a single epileptogenic zone. BSST/k can be applied to focal epilepsy with a simple parameter setting.SignificanceOur novel method was able to highlight IEDs with increased accuracy for identification of IEDs from multi-channel MEG data. 相似文献
565.
《Clinical neurophysiology》2020,131(2):377-384
ObjectiveThe project aimed to determine the alterations in the effective connectivity (EC) neural network in patients with insular epilepsy based on interictal high-frequency oscillations (HFOs) from magnetoencephalography (MEG) data.MethodsWe studied MEG data from 22 insular epilepsy patients and 20 normal subjects. Alterations in spatial pattern and connection properties of the patients with insular epilepsy were investigated in the entire brain network and insula-based network.ResultsAnalyses of the parameters of graph theory revealed the over-connectivity and small-world configuration of the global connectivity patterns observed in the patients. In the insula-based network, the insular cortex ipsilateral to the seizure onset displayed increased efferent and afferent EC. Left insular epilepsy featured strong connectivity with the bilateral hemispheres, whereas right insular epilepsy featured increased connectivity with only the ipsilateral hemisphere.ConclusionsPatients with insular epilepsy display alterations in the EC network in terms of both whole-brain connectivity and the insula-based network during interictal HFOs.SignificanceAlterations of interictal HFO-based networks provide evidence that epilepsy networks, instead of epileptic foci, play a key role in the complex pathophysiological mechanisms of insular epilepsy. The dysfunction of HFO networks may prove to be a novel promising biomarker and the cause of interictal brain dysfunctions in insular epilepsy. 相似文献
566.
Jing Ren Qun Yao Minjie Tian Feng Li Yueqiu Chen Qiqi Chen Jing Xiang Jingping Shi 《The journal of headache and pain》2022,23(1)
BackgroundMigraine is a common and disabling primary headache, which is associated with a wide range of psychiatric comorbidities. However, the mechanisms of emotion processing in migraine are not fully understood yet. The present study aimed to investigate the neural network during neutral, positive, and negative emotional stimuli in the migraine patients.MethodsA total of 24 migraine patients and 24 age- and sex-matching healthy controls were enrolled in this study. Neuromagnetic brain activity was recorded using a whole-head magnetoencephalography (MEG) system upon exposure to human facial expression stimuli. MEG data were analyzed in multi-frequency ranges from 1 to 100 Hz.ResultsThe migraine patients exhibited a significant enhancement in the effective connectivity from the prefrontal lobe to the temporal cortex during the negative emotional stimuli in the gamma frequency (30–90 Hz). Graph theory analysis revealed that the migraine patients had an increased degree and clustering coefficient of connectivity in the delta frequency range (1–4 Hz) upon exposure to positive emotional stimuli and an increased degree of connectivity in the delta frequency range (1–4 Hz) upon exposure to negative emotional stimuli. Clinical correlation analysis showed that the history, attack frequency, duration, and neuropsychological scales of the migraine patients had a negative correlation with the network parameters in certain frequency ranges.ConclusionsThe results suggested that the individuals with migraine showed deviant effective connectivity in viewing the human facial expressions in multi-frequencies. The prefrontal-temporal pathway might be related to the altered negative emotional modulation in migraine. These findings suggested that migraine might be characterized by more universal altered cerebral processing of negative stimuli. Since the significant result in this study was frequency-specific, more independent replicative studies are needed to confirm these results, and to elucidate the neurocircuitry underlying the association between migraine and emotional conditions. 相似文献
567.
纯音听觉优势半球--fMRI和脑磁图联合研究 总被引:3,自引:0,他引:3
目的 利用血氧水平依赖功能磁共振成像(BOLD-fMRI)和脑磁图(MEG)观察正常人在纯音刺激时听觉中枢的兴奋情况及两侧半球的差异。资料与方法 BOLD-fMRI研究对象为30名正常听力志愿者。BOLD-fMRI采用组块设计。声音刺激用140曲1kHz纯音,持续时间500in8,刺激间隔18,刺激施加频率1Hz。MEG检查共有10名正常受试者,采用90dB1kHz纯音刺激,持续时间8ms,刺激间期1s。用等电流偶极(ECD)描述皮质兴奋并将其与自身MRI图像叠加。结果 在BOLD-fMRI研究中,纯音刺激激活两侧听觉中枢和其周围邻近脑区,右侧半球听觉中枢的激活强度明显大于左侧。MEG检查中纯音刺激诱发的主要磁反应波为M100,M100 ECD位于初级听觉中枢预横回。右侧半球M100 ECD比左侧半球偏前、潜伏期短、强度高。结论 纯音刺激激活听觉中枢和周围脑区,右侧半球为纯音刺激时听觉的优势半球。 相似文献
568.
Recent investigations have studied the development of motor-related oscillatory responses to delineate maturational changes from childhood to young adulthood. While these studies included youth during the pubertal transition period, none have probed the impact of testosterone levels on motor cortical dynamics and performance. We collected salivary testosterone samples and recorded magnetoencephalography during a complex motor sequencing task in 58 youth aged 9–15 years old. The relationships between testosterone, age, task behavior, and beta (15–23 Hz) oscillatory dynamics were examined using multiple mediation modeling. We found that testosterone mediated the effect of age on movement-related beta activity. We also found that the effect of age on movement duration was mediated by testosterone and reaction time. Interestingly, the relationships between testosterone and motor performance were not mediated by beta activity in the left primary motor cortex, which may indicate the importance of higher-order motor regions. Overall, our results suggest that testosterone has unique associations with neural and behavioral indices of complex motor performance, beyond those already characterized in the literature. These findings are the first to link developmental changes in testosterone levels to maturation of beta oscillatory dynamics serving complex motor planning and execution, and specific measures of motor performance. 相似文献
569.
Humans’ extraordinary ability to understand speech in noise relies on multiple processes that develop with age. Using magnetoencephalography (MEG), we characterize the underlying neuromaturational basis by quantifying how cortical oscillations in 144 participants (aged 5–27 years) track phrasal and syllabic structures in connected speech mixed with different types of noise. While the extraction of prosodic cues from clear speech was stable during development, its maintenance in a multi-talker background matured rapidly up to age 9 and was associated with speech comprehension. Furthermore, while the extraction of subtler information provided by syllables matured at age 9, its maintenance in noisy backgrounds progressively matured until adulthood. Altogether, these results highlight distinct behaviorally relevant maturational trajectories for the neuronal signatures of speech perception. In accordance with grain-size proposals, neuromaturational milestones are reached increasingly late for linguistic units of decreasing size, with further delays incurred by noise. 相似文献