全文获取类型
收费全文 | 153篇 |
免费 | 4篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 9篇 |
妇产科学 | 1篇 |
基础医学 | 14篇 |
临床医学 | 39篇 |
内科学 | 15篇 |
神经病学 | 20篇 |
外科学 | 13篇 |
综合类 | 8篇 |
预防医学 | 26篇 |
药学 | 8篇 |
中国医学 | 4篇 |
出版年
2023年 | 4篇 |
2022年 | 5篇 |
2021年 | 9篇 |
2020年 | 5篇 |
2019年 | 11篇 |
2018年 | 7篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 2篇 |
2014年 | 12篇 |
2013年 | 27篇 |
2012年 | 5篇 |
2011年 | 6篇 |
2010年 | 4篇 |
2009年 | 4篇 |
2008年 | 6篇 |
2007年 | 9篇 |
2006年 | 4篇 |
2005年 | 3篇 |
2004年 | 2篇 |
2003年 | 1篇 |
2002年 | 3篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1997年 | 6篇 |
1995年 | 1篇 |
1993年 | 3篇 |
1986年 | 2篇 |
1977年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有158条查询结果,搜索用时 46 毫秒
21.
作者讨论了观测数据的独立性对统计结论的重要影响,给出了检验独立性的非参数检方法,便于医学科研人员有效地使用统计方法解决问题。 相似文献
22.
The neurochemical factors involved in the maintenance and breakdown of dopamine D1/D2 receptor synergism were investigated by giving rats various pharmacological treatments that diminish the ability of dopamine to interact with its D1 and/or D2 receptors. Following these treatments, rats were observed for the expression of stereotyped motor behavior in response to independent stimulation of D1 or D2 receptors. Independent D2-mediated responses were observed: (a) 2 h after the last of three daily reserpine (1 mg/kg) injections, (b) 48 h after bilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathways, (c) 24 h after a concentrated 48-h regimen (one injection/6 h) of eticlopride (0.5 mg/kg) or eticlopride + SCH 23390 (0.5 mg each), and (d) 2 h after a concentrated 48-h regimen (one injection/6 h) of α-methyl-p-tyrosine (αMPT; 100 mg/kg), but not after control treatments or a concentrated regimen of SCH 23390 alone. By contrast, independent D1-mediated responses were observed only after three daily reserpine injections or 48 h after bilateral 6-OHDA lesions. Independent D1-mediated stereotypy was not observed under control conditions or following a concentrated 48-h regimen of (a) SCH 23390 or eticlopride (0.5 mg/kg each) alone or in combination, (b) a high dose of SCH 23390 (1.0 mg/kg), (c) αMPT (100 mg/kg), or (d) αMPT (100 mg/kg)+SCH 23390 (1.0 mg/kg). Reserpine, bilateral 6-OHDA, and αMPT treatments produced striatal dopamine depletions of 96%, 92%, and 71%, respectively. These data indicate that the breakdown in D1/D2 synergism consists of two components: (a) D1 independence from the controlling influence of D2 receptors, and (b) D2 independence from the controlling influence of D1 receptors. The interaction of synaptic DA with its D2 receptors plays a major role in determining whether these receptors can function independently of D1 receptors, whereas reduced DA-D1 activity alone appears insufficient to elicit D1 independence. 相似文献
23.
Objective: To evaluate the effects of an increase in the intensity of rehabilitation on the functional outcome of patients with traumatic brain injury (TBI).
Design and methods: Sixty-eight patients (age 12-65 years) with moderate-to-severe TBI were included. They were randomized into high (4-hour/day) or control (2-hour/day) intensity rehabilitation programmes at an average of 20 days after the injury. The programmes ended when the patients achieved independence in daily activities or when 6 months had passed.
Outcome and results: No significant differences were found in the Functional Independence Measure (FIM) (primary outcome) and Neurobehavioural Cognitive Status Examination (NCSE) total scores between the two groups. There were significantly more patients in the high intensity group than in the control group who achieved a maximum FIM total score at the third month (47% vs. 19%, p = 0.015) and a maximum Glasgow Outcome Scale (GOS) score at the second (28% vs. 8%, p = 0.034) and third months (34% vs. 14%, p = 0.044).
Conclusions: Early intensive rehabilitation may improve the functional outcome of patients with TBI in the early months post-injury and hence increase the chance of their returning to work early. Intensive rehabilitation in this study speeded up recovery rather than changed the final outcome. 相似文献
Design and methods: Sixty-eight patients (age 12-65 years) with moderate-to-severe TBI were included. They were randomized into high (4-hour/day) or control (2-hour/day) intensity rehabilitation programmes at an average of 20 days after the injury. The programmes ended when the patients achieved independence in daily activities or when 6 months had passed.
Outcome and results: No significant differences were found in the Functional Independence Measure (FIM) (primary outcome) and Neurobehavioural Cognitive Status Examination (NCSE) total scores between the two groups. There were significantly more patients in the high intensity group than in the control group who achieved a maximum FIM total score at the third month (47% vs. 19%, p = 0.015) and a maximum Glasgow Outcome Scale (GOS) score at the second (28% vs. 8%, p = 0.034) and third months (34% vs. 14%, p = 0.044).
Conclusions: Early intensive rehabilitation may improve the functional outcome of patients with TBI in the early months post-injury and hence increase the chance of their returning to work early. Intensive rehabilitation in this study speeded up recovery rather than changed the final outcome. 相似文献
24.
泡囊狸殖与斯氏狸殖的比较及前者独立性的研究 总被引:4,自引:0,他引:4
确定泡囊狸殖的独立性。观察福建建瓯市蟹体中发现的泡囊狸殖囊蚴和以之感染家猫获得的成虫。比较斯氏狸殖、泡囊狸殖囊蚴与成虫等形态、结构特征。建瓯市蟹体内泡囊狸殖感染率为 2 0 .51 % ( 2 4 / 1 1 7) ,以 1 2个囊蚴感染 1只家猫 ,68天后解剖 ,在肺脏检及 6只成虫 ,经比较 ,成虫同斯氏狸殖无明显差别 ,而囊蚴同斯氏狸殖囊蚴有显著差别。由于泡囊狸殖斯氏狸殖囊蚴差异明显 ,所以泡囊并殖具独立性 相似文献
25.
26.
Gustaf Magaard Per Wester Richard Levi Peter Lindvall Emma Gustafsson Arzhang Nazemroaya Sedeh Malin Lönnqvist Stina Berggren Kristin Nyman Xiaolei Hu 《Journal of stroke and cerebrovascular diseases》2018,27(11):3224-3235
Background
Unmet rehabilitation needs are common among stroke survivors. We aimed to evaluate whether a comprehensive graphic “Rehab-Compass,” a novel combination of structured patient-reported outcome measures, was feasible and useful in facilitating a capture of patients' rehabilitation needs in clinical practice.Methods
A new graphic overview of broad unmet rehabilitation needs covers deficits in functioning, daily activity, participation, and quality of life. It was constructed by using 5 patient-oriented, well-validated, and reliable existing instruments with converted data into a 0 (worst outcome) to 100 (best outcome) scale but unchanged in terms of variable properties. Satisfaction of the Rehab-CompassTM was studied by a qualitative interview of 9 patients with stroke and 3 clinicians. Practical feasibility and capacity of the instrument were evaluated in a cross-sectionalstudy with 48 patients at 5-month follow-ups after subarachnoid hemorrhage.Results
The Rehab-CompassTM identified and graphically visualized a panoramic view of the multidimensional needs over time which was completed before clinical consultation. The Rehab-CompassTM appeared to be feasible and time-efficientin clinical use. The interviews of both patients and clinicians showed high satisfaction when using the Rehab-CompassTM graph. In the studied stroke patients, the Rehab-CompassTM identified memory and processing information, fatigue, mood, and pain after subarachnoid hemorrhage as the most common problems.Conclusions
The graphic Rehab-CompassTM seems to be a feasible, useful, and time-saving tool for identification of unmet rehabilitation needs among stroke survivors in clinical practice. Further research is needed to make the Rehab-CompassTM more concise and evaluate the instrument among different stroke subgroups. 相似文献27.
Tytti Sarkeala Tapio Nummi Merja Vuorisalmi Antti Hervonen Marja Jylh? 《European journal of ageing》2011,8(2):87-94
Substantial growth of the population aged 90 years or over has focused interest on trends in the functioning and disability
of the oldest old, but research findings are scarce and they vary. In the Vitality 90+ Study, we evaluated overall, gender-specific,
and age-specific trends in disability among total cohorts of people aged 90 years or older in the city of Tampere, Finland,
in the years 2001, 2003, and 2007. The size of the target population ranged from 1113 to 1146 and the participation rate from
79 to 86%. The participants were asked whether they were able to get in and out of bed, dress and undress, move about indoors,
walk 400 m, and use stairs. Independence was defined as being able to perform an activity without help. The aggregate outcome
measures included independence in all five activities, dependence in one to four activities, dependence in all five activities
(severe dependence), and a disability score. In analyses taking into account the within subject associations which resulted
due to those who participated in several years, and proxy respondents, no overall or gender-specific trend was found in any
of the independence or dependence estimates. In each year, independence decreased clearly by increasing age. Our results imply
stable disability levels in nonagenarians in a population with increasing life expectancy and improving survival until the
age of 90. Longer-time series are needed to confirm the trends. 相似文献
28.
Reilly KT Hammond GR 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2006,173(4):564-571
Although the superior dexterity of one hand is an almost ubiquitous human experience, it is unclear which characteristics of the motor system controlling the preferred hand produce this superior dexterity. Between-species studies show that greater dexterity is associated with a motor system that permits more independent movements of the digits. If between-hand dexterity differences are mediated by the same mechanism as between-species dexterity differences, then there should be asymmetries within the corticospinal tracts of humans that would result in between-hand independence differences. The evidence for asymmetries in the corticospinal tracts is sparse, and if an asymmetry does exist, it appears to be limited to the control of intrinsic hand muscles. We wondered, therefore, whether there might be a difference in the degree of independent control on the two hands during performance of a task that primarily uses intrinsic hand muscles. We examined digit individuation when subjects produced abduction or adduction forces with a single digit in isolation. Consistent with previous studies in which forces or movements in single digits were generated primarily by extrinsic hand muscles, we found no difference between the individuation of the digits on the preferred and non-preferred hands. We suggest that whereas independence differences underlie large dexterity differences between species, they do not underlie the more subtle dexterity differences between the preferred and non-preferred hands. Instead, the neural substrate for handedness might be asymmetrical connectivity within M1, with more profuse connections within the dominant than non-dominant M1 imparting a greater potential for excitatory and inhibitory interactions between movement representations which might then result in the more efficient coordination of hand and arm movements of the preferred hand. 相似文献
29.
30.
胡艳丽 《中国听力语言康复科学杂志》2013,(5):384-386
目的探讨增加听障儿童角色游戏自主参与时间,发展交往能力的策略。方法以56名4~5岁听障儿童为研究对象,观察、记录调整干预指导策略前后其在角色游戏中自主参与游戏时间的变化,采用SPSS 19.0软件对两次数据进行配对样本t检验。结果指导策略调整前后,教师在角色游戏中介入的时间具有极其显著性差异(P=0.00);听障儿童在角色游戏中自主游戏的时间发生了极其显著的改变(P=0.00)。结论调整角色游戏指导策略是提高听障儿童角色游戏自主性的有效方法,教师要缩短对儿童游戏的控制时间,引导儿童自主组织、实施和评价游戏。 相似文献