A case of acute psychosis in a patient following exposure to a single high dose of styrene

We report a case of acute psychotic symptoms following exposure to a single high dose of styrene monomer. The 24‐year‐old male patient showed psychotic and cognitive symptoms immediately after exposure. His psychotic symptoms included auditory hallucinations and delusions of reference. Brain magnetic resonance imaging, electroencephalography, and laboratory examinations were performed to evaluate any other causes. The clinical, neuroimaging, and laboratory review in this case suggested that the suddenly developed psychotic symptoms that led to chronic deterioration were caused by the single exposure to styrene monomer. This is the first recent report in which acute psychotic symptoms developed from a single high dose of styrene suffocation compared with previous findings showing symptoms because of long‐term low‐dose exposure.     

首发精神分裂症患者心肌酶谱变化及临床意义

目的观察首发精神分裂症(SZ)患者心肌酶谱变化及临床意义。方法选取2018年2月～2019年11月本院收治的精神分裂症患者100例,按照精神分裂症阳性和阴性症状量表(PANSS)分为阳性症状组和阴性症状组,另选取本院同期体检健康职工32例,作为健康组。分别于治疗前和治疗4周后采集SZ患者外周血4 mL,健康组患者于体检时抽取,检测样本乳酸脱氢酶(LDH)、肌酸激酶(CK)、天门冬氨酸氨基转移酶(AST)水平,对SZ患者治疗前后、SZ患者与健康组血清心肌酶谱水平进行比较分析。结果阳性症状组治疗前、治疗后血清LDH、CK、AST水平显著高于阴性症状组(P0.05);治疗后两组患者血清LDH、CK、AST水平均低于治疗前(P0.05);Spearman秩相关分析结果显示,SZ患者血清LDH、CK、AST水平与阳性症状量表得分具有相关性(P0.05);治疗前SZ患者血清LDH、CK、AST水平显著高于健康组(P0.05);血清CK诊断SZ的曲线下面积(AUC)最大,敏感度和特异度显著优于LDH、AST(P0.05)。结论首发精神分裂症患者心肌酶谱存在异常增高现象,血清LDH、CK、AST水平与SZ患者阳性症状有相关性,CK对SZ的临床诊断具有一定的参考价值。