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81.
H. Teshima S. Beaudenon S. Koi K. Katase K. Hasumi K. Masubuchi G. Orth 《Archives of gynecology and obstetrics》1997,259(4):169-177
Human papillomavirus (HPV) DNA sequences were detected by Southern blot hybridization and polymerase chain reaction (PCR)
in 10 out of 19 patients (52.7%) with adenocarcinoma [15] and adenosquamous [4] carcinoma of the uterine cervix. HPV 18 DNA
was detected in 8 of these 19 patients (42.1%), HPV 16 DNA in 1 patient (5.3%) and HPV type X (unknown) in another (5.3%).
Of the 10 HPV positive samples HPV 18 was found in 6 out of 6 pure adenocarcinomas (100%), and in 2 of 4 (50%) adenosquamous
carcinomas. HPV 16 and HPV X were each detected in 1 out of 4 (25%) adenosquamous carcinomas. The physical state of the viral
DNA was investigated in 5 of the 10 HPV-positive cases. All the specimens from these 5 cases showed HPV to be integrated into
the host genome, except for one adenosquamous specimen, which showed both episomal and integrated forms of HPV 16. Six of
8 HPV 18 DNA positive specimens were from cases of pure adenocarcinoma and it was found by PCR that five of these 6 specimens
retained fragments of E6/E7, LCR/E7 and early sequence of E1 fragment (sequence: 1188–1373) but deleted most part of E1. 相似文献
82.
L. Selvaggi G. Di Vagno E. Maiorano G. Cormio G. Loverro G. Nacci R. Ricco 《Archives of gynecology and obstetrics》1997,259(4):197-200
A case of giant (32 Kg) malignant fibrous histiocytoma (MFH) arising from the uterus and occupying the entire abdomen and
the pelvis is reported. The patient had debulking surgery, followed by combination chemotherapy, but died 7 months after diagnosis. 相似文献
83.
Anne M. Weber MD Allison R. Mitchinson MPH Gita P. Gidwani MD Edward Mascha MS Mark D. Walters MD 《American journal of obstetrics and gynecology》1997,176(6):1213-1219
OBJECTIVE: Our purpose was to describe clinical characteristics in premenopausal women with uterine myomas and to identify factors associated with hysterectomy.STUDY DESIGN: Data were collected by chart abstraction in 421 premenopausal women with myomas and analyzed by univariate and multivariable regression.RESULTS: Over a median follow-up period of 29 months, 86% of women had symptoms associated with myomas and 40% had an increase in uterine size of >2 gestational weeks. By multivariable regression, bleeding symptoms at presentation and previous surgical history of cholecystectomy and adhesiolysis were significantly associated with greater odds of hysterectomy. There was a significant interaction between age and uterine size, so that as age increased, uterine size had a greater impact on the likelihood of hysterectomy.CONCLUSIONS: In this cohort of premenopausal women myomas were associated with symptoms in almost all women over the follow-up period. Hysterectomy was performed in 22% of women overall. (Am J Obstet Gynecol 1997;176:1213-9.) 相似文献
84.
绝经后阴道出血患者诊断性刮宫前B超检测子宫内膜的价值 总被引:53,自引:0,他引:53
目的:评估绝经后阴道出血患者应用B超检测子宫内膜,以减少不必要的诊断性刮宫术(诊刮术)的价值。方法:对192例绝经后阴道出血患者,于诊刮术前行B超检查,测量子宫大小及子宫内膜厚度,然后进行分段诊刮术,标本送病理检查。结果:77例内膜厚度≤4mm者中,74例(96.1%)子宫内膜属生理性改变,3例为内膜癌;115例子宫内膜厚度≥5mm者中,92例(80.0%)子宫内膜属病理性改变,其中59例(51.3%)为内膜癌。结论:高分辨阴道B超检测,可作为绝经后出血患者进行诊刮术前的一种筛选手段,当超声检测内膜厚度≤4mm时,可考虑避免诊刮术。 相似文献
85.
Objective: To investigate the significance of c-erbB-2 and PCNA expression in adenocarcinoma. Methods: Expression of c-erbB-2
and PCNA in 74 cases of adenocarcinoma of the uterine cervix was examined by immunohistochemistry. Results: The expression
of c-erbB-2 was detected in 34 cases. The positive staining of c-erbB-2 was associated with increased lymph node metastasis
(57.1% Vs 24.0%, P=0.041) and lower 5-year survival rate (32.4% Vs 58.9%, P=0.008). The average PCNA labeling index (PCNA
LI) was 40.6% (0.1%–91.4%). High PCNA LI was associated with lymph node metastasis (56.4% Vs 38.5%, P=0.016) and lower 5-year
survival rate (28.7% Vs 64.4%, P=0.005). Positive staining of c-erbB-2 were associated with high PCNA LI (44.7% Vs 34.6% P=0.003).
Conclusions: c-erbB-2 and PCNA LI were associated with malignant biological behavior and poor prognosis of patients with cervical
adenocarcinoma. 相似文献
86.
87.
目的了解子宫内膜癌发病的高危因素,探讨其早期诊断的手段。方法对42例子宫内膜癌的病史、临床表现、诊断技术及病理类型进行分析。结果子宫内膜癌占同期生殖系统恶性肿瘤病人的38.1%,不规则子宫出血是子宫内膜癌的主要症状,其次是阴道排液增多。不孕病人及更年期功能性子宫出血长期受无孕激素桔抗的雌激素刺激是本病的高危因素。结论诊断性刮宫及超声波探查对诊断及分期是必不可少的方法。 相似文献
88.
米非司酮配伍与不配伍甲基睾丸素治疗子宫肌瘤的临床研究 总被引:17,自引:1,他引:17
目的:评价米非司酮配伍与不配伍甲基睾丸素治疗子宫肌瘤的临床效果。方法:有症状的子宫肌瘤患者60例,随机分为两组,每组30例。A组:口服米非司酮及甲基睾丸素。米非司酮25mg,甲基睾丸素5mg,每日1次,连服90天;B组:口服米非司酮及安慰剂,服药方法同A组。结果:两组治疗后均使患者发生闭经。A组治疗后经量减少4932%,瘤体缩小5220%;B组治疗后经量减少3980%,瘤体缩小4410%。结论:抗雌孕激素的联合治疗是保守性治疗子宫肌瘤较为理想的方法。 相似文献
89.
目的:观察我院骨髓移植治疗恶性血液病的疗效、探讨移植相关并发症的预防及处理等问题。方法:4例行HLA相合的同胞间异基因外周干细胞移植(Allo-PBSCT)、2例行自体外周干细胞移植(APBSCT)和1例行自体骨髓移植(Au-to-BMT)。结果:全部病例均成功造血重建。中性粒细胞≥0·5×109/L平均时间为11天;血小板≥20×109/L平均时间为16天;发生Ⅱ~Ⅲ度aGVHD1例,cGVHD1例,溶血性贫血2例,间质性肺炎2例,中位随访时间18(6~42)月,全部病例现均存活。结论:骨髓移植治疗恶性血液病有较好疗效。 相似文献
90.