Energy-efficient cabin climate control of electric vehicles using linear time-varying model predictive control

A cabin climate control system, often referred to as a heating, ventilation, and air conditioning (HVAC) system, is one of the largest auxiliary loads of an electric vehicle (EV), and the real-time optimal control of HVAC brings a significant energy-saving potential. In this article, a linear-time-varying (LTV) model predictive control (MPC)-based approach is presented for energy-efficient cabin climate control of EVs. A modification is made to the cost function in the considered MPC problem to simplify the Hessian matrix in utilizing quadratic programming for real-time computation. A rigorous parametric study is conducted to determine optimal weighting factors that work robustly under various operating conditions. Then, the performance of the proposed LTV-MPC controller is compared against a rule-based (RB) controller and a nonlinear economic MPC (NEMPC) benchmark. Compared with the RB controller benchmark, the LTV-MPC reaches the target cabin temperature at least 69 s faster with 3.2% to 15% less HVAC system energy consumption, and the averaged cabin temperature difference is 0.7°C at most. Compared with the NEMPC, the LTV-MPC controller can achieve comparable performance in temperature regulation and energy consumption with fast computation time: the maximum differences in temperature and energy consumption are 0.4°C and 2.6%, respectively, and the computational time is reduced 72.4% on average with the LTV-MPC.     

Exosomes: Potent regulators of tumor malignancy and potential bio-tools in clinical application

Multiple lines of evidence indicate that exosomes, as efficient messengers in cell-to-cell communication, play pleiotropic roles in regulating tumor malignancy. The cargos (proteins, mRNAs, and miRNAs) carried by exosomes can be functionally delivered between different types of cells and even transferred to distant locations, influencing the biological activities of tumor and non-tumor cells and promoting tumor growth, invasion, metastasis, angiogenesis, and drug resistance. Tumor-associated exosomes have been identified in biological (plasma, urine, saliva) and pathological (malignant effusions, pleural effusions, ascites) fluids from cancer patients. The contents of exosomes may vary depending on tumor types and status. Detection of exosomes in biofluids of cancer patients may represent a promising strategy to gain pathogenic information and to select specific biomarkers for the diagnosis and prognosis of cancer. Utilization of exosomes as delivery vehicles for siRNAs and therapeutic drugs brings out new concepts such as biomimetics in cancer treatment. In this review, we will mainly discuss emerging roles of exosomes in tumor invasion, metastasis, angiogenesis, and drug resistance and potential clinical application of exosomes as biomarkers and therapeutic tools.     

Milk-derived exosomes exhibit versatile effects for improved oral drug delivery

As endogenous courier vesicles, exosomes play crucial roles in macromolecule transmission and intercellular communication. Therefore, exosomes have drawn increasing attention as biomimetic drug-delivery vehicles over the past few years. However, few studies have investigated the encapsulation of peptide/protein drugs into exosomes for oral administration. Additionally, the mechanisms underlying their biomimetic properties as oral delivery vehicles remain unknown. Herein, insulin-loaded milk-derived exosomes (EXO@INS) were fabricated and the in vivo hypoglycemic effect was investigated on type I diabetic rats. Surprisingly, EXO@INS (50 and 30 IU/kg) elicited a more superior and more sustained hypoglycemic effect compared with that obtained with subcutaneously injected insulin. Further mechanism studies indicated that the origin of excellent oral-performance of milk-derived exosomes combined active multi-targeting uptake, pH adaptation during gastrointestinal transit, nutrient assimilation related ERK1/2 and p38 MAPK signal pathway activation and intestinal mucus penetration. This study provides the first demonstration that multifunctional milk-derived exosomes offer solutions to many of the challenges arising from oral drug delivery and thus provide new insights into developing naturally-equipped nanovehicles for oral drug administration.     

Wounding characteristics and treatment principles of ground anti-armored vehicle ammunition against armored crew

The wound mechanism, injury characteristics and treatment principles of anti-armored vehicle ammunition against armored crew in the past 20 years are summarized in this paper. Shock vibration, metal jet, depleted uranium aerosol and post armor breaking effect are the main factors for wounding armored crew. Their prominent characteristics are severe injury, high incidence of bone fracture, high rate of depleted uranium injury, and high incidence of multiple/combined injuries. During the treatment, attention must be paid on that the space of armored vehicle is limited, and the casualties should be moved outside of the cabin for comprehensive treatment. Especially, the management of depleted uranium injury and burn/inhalation injury are more important than other injuries for the armored wounds.