Contrast-enhanced magnetic resonance angiography of carotid arterial wall in pigs

This study was designed to investigate the effects of contrast agents on MR images of balloon-injured carotid arteries containing atherosclerotic-like lesions. We have evaluated an intravascular contrast agent, MS-325 (METASYN INC., Cambridge, MA) and an extra-vascular contrast agent, Optimark, (Mallinckrodt Medical Inc., St. Louis, MO) on MR angiograms obtained 4 weeks after balloon hyperinflation-induced injury of the left common carotid artery in 12 hypercholesterolemic minipigs. High in-plane resolution (.8 × .4 mm²), thin slice (1 mm) time-of-flight gradient echo sequences were used to acquire the MR angiographic images. Vascular lumen definition was compared before and after a single bolus intravenous injection of a contrast agent. Digital subtraction angiograms were obtained from all pigs after MR imaging. High grade stenosis developed in 1 of the 12 pigs and five pigs had complete occlusion of the injured vessel. The remaining pigs exhibited essentially no visible stenoses as assessed either by MR angiography or digital subtraction angiography. The vessel walls of the stenosed and occluded vessels were visible after the injection of either intravascular or extravascular contrast agent. Histologic analyses showed well developed neovascularization in the neointima or occlusive thrombosis. We conclude that the observed contrast-enhanced vessel wall is caused by an increased vascular supply associated with thrombosis and neointimal thickening that leads to an accumulation of contrast agent in the abnormal vessel walls after the injection of the T1-shortening paramagnetic contrast agent.     

Safety and efficacy of lifibrol upon four-week administration to patients with primary hypercholesterolaemia

The efficacy and safety of lifibrol, a novel cholesterol-lowering drug, was investigated in a double-blind clinical study in 168 patients with primary hypercholesterolaemia. Placebo and four lifibrol dose groups (150, 300, 450 and 600 mg/day) were tested over a period of 4 weeks.The mean LDL-cholesterol changes were 5.7%, –11.1%, –27.7%, –34.5% and –35.0%, respectively, after 4 weeks of treatment. No major changes in HDL-cholesterol were seen after this period. With the present study design, a decrease in triglycerides (–28%) was significant in the highest dosage group only. Additionally, it was shown that further independent risk factors for coronary heart disease were favourably influenced. Fibrinogen decreased in all dosage groups with a maximal mean value of 18% and a tendency toward reduction in lipoprotein (a) was observed in patients with high baseline levels (>30 mg·dl^–1).Lifibrol was generally well tolerated in all dosage groups and no serious adverse events were reported. Laboratory parameters did not show any clinically relevant alterations.P. Schwandt is representing the 22 medical centres of the Lifibrol Study Group     

喹胺酸和LICAM(C)对大鼠体内238Pu和241Am的促排效果比较

喹胺酸(Quinamic acid, QAA, 811)是一种异哇啉类络合剂, 对钍有较好的促排效果。本文主要研究大鼠静脉注入(iv)²³⁸Pu和²⁴¹Am各26kBq/kg后1小时, 经皮下注入(so)不同剂量.(1～30μmol/kg)QAA, 或静脉注入核素后立即灌胃(po)QAA(30μmol/kg)对²³⁸Pu、²⁴¹Am的促排疗效, 并与LICAM(C)相比较。实验观察到QAA对降低骨肝中²³⁸Pu、²⁴¹Am的蓄积量有较好的作用, QAA对²³⁸Pu的促排效果高于对²⁴¹Am.在剂量(1～30μgmol/kg)对肝、肾中²³⁸Pu和骨、肾中²⁴¹Am蓄积量的降低, QAA优于LICAM(C)；灌胃QAA(30μttmol/kg)伍用NaHCO₃(5mmol/kg的)疗效, 对骨、肝中²³⁸Pu蓄积量的降低, QAA和LICAM(C)二间无差异(P>0.05), 但对²³⁸Pu在肾中蓄积量和对²⁴¹Am在骨, 肾中蓄积量的降低, QAA明显优于LICAM(C)。     

Conventional industrial foam rubber as an alternative dressing for large skin grafts in plastic surgery

Industrially manufactured foam rubber (polyurethane) is clinically used as variable, hygienic mattresses and also serves as a positioning aid during surgery. It can be sterilized and used to cover large skin grafts; it conforms well to the anatomical topography. It is stapled together with the skin graft, this allows mobilization of patients with large skin grafts i.e. >10% body surface area.     

脑电地形图检查在肺炎支原体脑炎诊断治疗中的应用价值

本组69例肺炎支原体感染患儿脑电地形图有不同程度改变。其中72.5％伴有多脏器损害,年龄越小多脏器损害率越高,且与脑电地形图异常程度成正比。脑电地形图检查对脑神经损害的诊断及恢复期监测有较大临床价值。     

几种抗绿脓杆菌药物疗效筛选的实验研究

采用大鼠 TBSA15%Ⅲ度烧伤模型,伤后创面涂绿脓杆菌(10~9/ml)后共分6组。其中5个组的创面分别涂以不同药物,对照组不涂药。通过对各组创面外观、痂下细菌定量与病理组织学观察,皆证实 AgSD-ZnSD-A 霜组效果最好,是满意的烧伤外用药。     

新型强心药物──Pimobendan的合成研究

本文叙述了以乙酰苯胺为起始原料合成新型强心药物Ｐｉｍｏｂｅｎｄａｎ的新的合成方法，总收率为３．５１％，关键中间体及最终化合物的结构经光谱分析得到了确证。     

抗病毒药物2，5，6-三取代－4（3H）嘧啶酮衍生物的合成及诱导干扰素活性

抗病毒药物２，５，６-三取代－４（３Ｈ）嘧啶酮衍生物的合成及诱导干扰素活性刘新泳，徐丽君（山东医科大学药学系济南２５００１２）取代嘧啶酮类化合物是一类小分干扰素诱导剂，有抗病毒、抗肿瘤、杀菌抑霉、诱导干扰素和白介素、免疫调节等多种生物活性（１）。目前?..