X线平片与MSCT三维重建在桡骨远端骨折诊断中的价值分析

目的 探讨X线平片与多层螺旋CT(MSCT)三维重建在桡骨远端骨折诊断中的价值.方法 回顾性分析本院2016年2月至2018年11月收治的200例桡骨远端骨折患者临床资料,所有患者均先后X线平片与MSCT三维重建检查,比较X线平片与MSCT三维重建诊断结果差异.结果 本研究200例患者中,X线平片共确诊桡骨远端骨折18...     

手法与外固定器在桡骨远端不稳定骨折治疗中的应用

目的：总结手法与改良Ilizarov外固定器在桡骨远端不稳定骨折治疗中的应用经验。方法：2005年～2008年,采用手法复位,改良Ilizarov外固定器治疗30例桡骨远端不稳定骨折。其中,A3型12例,B2型3例,C1型8例,C2型4例,C3型3例。结果：全部病例均获得随访,采用Batra腕关节评分标准进行评分,其中优15例,良11例,可1例,差3例,平均86.27分。结论：手法与改良Ilizarov外固定器结合治疗桡骨远端不稳定骨折方法简单,疗效满意,是建立在一般桡骨远端骨折复位手法基础上的,借助器械和术后康复的的一套行之有效的方法。     

两种仪器测量角膜曲率及其半径的效果比较

【摘要】 目的 比较角膜地形图仪（Pentacam）与光学生物测量仪（IOLMaster）对角膜曲率及其半径测量结果的异同，为不同的临床需求提供准确便捷的检查方法。方法 选择年龄（2080±129）岁的受检者共40例，80只眼，分别应用Pentacam与IOLMaster进行角膜曲率及其半径的测量，进行t检验比较、Pearson相关性分析并应用Bland Altman 分析对两种测量方法进行一致性评价。结果 Pentacam与IOLMaster所测得的平均K值分别为（4356±168） D和（4362±159） D，平均R值分别为（776±005） mm和（774±005） mm，经配对t检验结果差异均无统计学意义（P＞005）；Pentacam与IOLMaster对角膜曲率及曲率半径测量结果相关系数平方为09741及09573，结果均显示出较高相关性，两种方法测量的K值及R值一致性较差。结论 两种仪器测量角膜曲率及曲率半径呈较高相关性，但一致性差，不可任意替代使用，需根据不同临床需求做出合理选择。     

伸直型与屈曲型桡骨远端骨折手术疗效对比

目的:比较掌侧锁定接骨板内固定治疗伸直型与屈曲型桡骨远端骨折的疗效.方法:自2015 年 1 月至2018年6月采用掌侧锁定接骨板内固定治疗桡骨远端骨折患者103例,根据原始骨折移位方向分为伸直型(Colles)骨折组和屈曲型(Smith)骨折组.Colles 骨折组68 例,其中男24 例,女44 例;年龄20～79...     

Axial and radial axonal diffusivities and radii from single encoding strongly diffusion-weighted MRI

We enable the estimation of the per-axon axial diffusivity from single encoding, strongly diffusion-weighted, pulsed gradient spin echo data. Additionally, we improve the estimation of the per-axon radial diffusivity compared to estimates based on spherical averaging. The use of strong diffusion weightings in magnetic resonance imaging (MRI) allows to approximate the signal in white matter as the sum of the contributions from only axons. At the same time, spherical averaging leads to a major simplification of the modeling by removing the need to explicitly account for the unknown distribution of axonal orientations. However, the spherically averaged signal acquired at strong diffusion weightings is not sensitive to the axial diffusivity, which cannot therefore be estimated although needed for modeling axons — especially in the context of multi-compartmental modeling. We introduce a new general method for the estimation of both the axial and radial axonal diffusivities at strong diffusion weightings based on kernel zonal modeling. The method could lead to estimates that are free from partial volume bias with gray matter or other isotropic compartments. The method is tested on publicly available data from the MGH Adult Diffusion Human Connectome project. We report reference values of axonal diffusivities based on 34 subjects, and derive estimates of axonal radii from only two shells. The estimation problem is also addressed from the angle of the required data preprocessing, the presence of biases related to modeling assumptions, current limitations, and future possibilities.     

Phyllanthus emblica (Amla) methanolic extract regulates multiple checkpoints in 15-lipoxygenase mediated inflammopathies: Computational simulation and in vitro evidence

Amla (Phyllanthus emblica) has long been used in traditional folk medicine to prevent and cure a variety of inflammatory diseases. In this study, the antioxidant activity (DPPH scavenging and reducing power), anti-inflammatory activity (RBC Membrane Stabilization and 15-LOX inhibition), and anticoagulation activity (Serin protease inhibition and Prothrombin Time assays) of the methanolic extract of amla were conducted. Amla exhibited a substantial amount of phenolic content (TPC: 663.53 mg GAE/g) and flavonoid content (TFC: 418.89 mg GAE/g). A strong DPPH scavenging effect was observed with an IC₅₀ of 311.31 µg/ml as compared to standard ascorbic acid with an IC₅₀ of 130.53 µg/ml. In reducing power assay, the EC₅₀ value of the extract was found to be 196.20 µg/ml compared to standard ascorbic acid (EC₅₀ = 33.83 µg/ml). The IC₅₀ value of the RBC membrane stabilization and 15-LOX assays was observed as 101.08 µg/ml (IC₅₀ of 58.62 µg/ml for standard aspirin) and 195.98 µg/ml (IC₅₀ of 19.62 µg/ml for standard quercetin), respectively. The extract also strongly inhibited serine protease (trypsin) activity with an IC₅₀ of 505.81 µg/ml (IC₅₀ of 295.44 µg/ml for standard quercetin). The blood coagulation time (PTT) was found to be 11.91 min for amla extract and 24.11 min for standard Warfarin. Thus, the findings of an in vitro study revealed that the methanolic extract of amla contains significant antioxidant, anti-inflammatory, and anticoagulation activity. Furthermore, in silico docking and simulation of reported phytochemicals of amla with human 15-LOXA and 15-LOXB were carried out to validate the anti-inflammatory activity of amla. In this analysis, epicatechin and catechin showed greater molecular interaction and were considerably stable throughout the 100 ns simulation with 15-lipoxygenase A (15-LOXA) and 15-lipoxygenase B (15-LOXB) respectively.     

BOLD螺钉内固定治疗MasonⅡ型桡骨头骨折

目的 探讨采用BOLD螺钉分步延期（ORIF）治疗MasonⅡ型桡骨头骨折的方法 和临床疗效,为临床治疗此类骨折提供参考.方法 对16例MasonⅡ型桡骨头骨折采用BOLD螺钉行ORIF,术后石膏固定10 d,早期功能锻炼.按照Broberg和Morrey的评定标准对肘关节功能评分.结果 16例均获随访,随访时间12～53个月,平均23个月.肘关节功能评分为92.0～100.0分,平均为98.3分;其中优15例,良1例.结论 采用BOLD螺钉ORIF治疗MasonⅡ型桡骨头骨折,手术创伤小、功能恢复好,是治疗成人MasonⅡ型桡骨头骨折较好的方法.