SARS胸部影像表现与评价(附75例分析)

目的：回顾分析75例严重急性呼吸综合症(SARS)病例，探讨该病影像学表现及其与临床治疗有关的问题。方法：全部75例患者均行胸片检查，一般隔日行影像追踪复查。结果：胸部X线表现为肺实质渗出病灶为主，肺内网状改变及肺门片块影较少。影像表现与临床病程有一定关系。结论：胸部影像表现以肺实质渗出病灶较常见。胸片检查是进行本病诊断和评估病程及疗效的重要方法。     

皮质激素对人体血管收缩试验的研究

在20名正常人前臂内侧涂以4种以清凉油为基质含不同浓度地塞米松(0.1、0.05、0.025、0.0125%)的皮炎速灵油膏,并以清凉油作阴性对照,地塞米松软膏作阳性对照。采用改良的Mckenzie和Stoughton法,将六种药剂涂于同一个体,以消除个体间反应差异。涂药后3h拭去药物,再经2、3、4、5、7、9及21h进行观察并打分,在双盲条件下根据用药部位发白情况由3名评估者对每名受试者独立打分,应用Wilcoxon等经典秩和试验法进行统计分析,结果显示清凉油和所有含地塞米松的制剂之间存在着非常显著的差异,并对受试者反应和评估者打分的变异系数进行了计算。我们的体会是血管收缩试验在黄种人也是可行的,而这种打分系统只要提供足够数量的受试者,特别适宜于应用Wilcoxon等统计方法。     

76例宫颈癌组织中人类乳头瘤病毒的检测

本文应用ＨＰＶ－ＰＣＲ技术和ＤＮＡ杂交技术对７６例宫颈鳞癌标本进行了ＨＰＶ－ＤＮＡ的研究，发现ＨＰＶ－ＤＮＡ存在率为９０．７９％（６９／７６），主要类型为ＨＰＶ１６和１８。多酶切ＳｏｕｔｈｅｒｎＢｌｏｔ杂交证实在宫颈癌中９２．５６％的ＨＰＶ－ＤＮＡ发生变异，说明ＨＰＶ－ＤＮＡ的基因变异与其致癌作用密切相关。ＰＣＲ结果证实ＨＰＶ－Ｅ６片段在宫颈癌组织中常可出现，推测可能是致癌的关键片段之一。因此，检测宫颈癌组织中ＨＰＶ－ＤＮＡ的完整性、关键基因片段的存在与否，可能对于病变恶变的预测有一定的意义     

Patients seeking symmetrical recontouring for “Perceived” deformities in the width of the face and skull

This article describes plastic surgery patients who sought symmetrical recontouring of the width of the face and skull. The basic demographic and personality characteristics of these facial width deformity (FWD) patients and the surgical procedures performed on them are discussed. Details of the surgical and psychological management of three representative cases are given. Speculative conclusions regarding the general characteristics of the FWD population are offered. Suggestions are proposed for a combined surgical-medical psychotherapeutic collaboration in managing these patients.     

亚硒酸钠对荷Lewis肺癌小鼠癌组织和肝组织溶酶体的作用研究

用差速离心方法分离提取荷Lewis肺癌小鼠癌组织和肝组织富含溶酶体部分,并以溶酶体标志酶酸性磷酸酶(ACP)的游离酶和总酶活性比值作为观察溶酶体膜稳定性变化的指标,观察了亚硒酸钠对两种组织ACP酶活性和膜稳定性的影响。发现硒对癌组织和肝组织ACP活性的异常升高有抑制作用、稳定溶酶体膜,在癌瘤增殖前期作用明显(P<0.05)。提示这种拮抗效应与硒直接和间接的抗脂质过氧化有关。     

恶性肿瘤患者血清癌胚抗原放射免疫分析

本文采用放射免疫法测定了144例恶性肿瘤患者血清CEA含量,并以同样条件测定了30例正常人作为对照。结果表明恶性肿瘤患者血清CEA含量显著高于健康人,均值为10.3±4.84ng/ml。不同肿瘤患者血清CEA升高的程度不等,其中以肺癌含量最高为14.7±7.83ng/ml。转移性肿瘤CEA含量高于144例肿瘤的平均水平。术后复发者含量不见下降。癌性胸腹水中CEA含量明显升高。因此,血清CEA的测定对恶性肿瘤的辅助诊断,评价疗效和判断预后具有重要的临床意义。     

Correlation between 1.25 dihydroxyvitamin D serum levels and fractional rate of intestinal calcium absorption in hypercalciuric nephrolithiasis. role of phosphate

Summary Different mechanisms could explain the elevated calcium elimination, the main cause of calcium oxalate renal stones. Our results suggest that phosphate levels are decreased in patients with absorptive hypercalciuric nephrolithiasis and elevated serum dihydroxyvitamin D. This could be the reason why in this group of patients oral phosphate treatment prevented hypercalciuria and renal lithiasis.This work was supported by FlSss 89/0799     

Calorie restriction increases serum parathyroid hormone and decreases serum calcitonin levels in patients with maturity onset diabetes mellitus

Calorie restriction is important in managing patients with maturity onset diabetes mellitus (NIDDM). The effect of such restriction on calcium metabolism is not known. The objective of this study was to determine whether patients on calorie restricted diets would show any modification of parathyroid hormone (PTH) and calcitonin (CTN). The serum levels of PTH and CTN were measured by radioimmunoassays in 269 patients with NIDDM. The patients were divided into two groups depending on the intake of calorie, and PTH and CTN were monitored for 2 years. Plasma levels of vitamin D were measured by competitive protein binding assays before and after each program. The level of PTH (520.8±266.0 pg/ml) (mean±S.D.) was significantly (P<0.01) higher in 109 diabetic patients whose calorie intake was restricted for 2 years (diet (D) group) as compared with that (256.6±103.8 pg/ml) of 160 diabetic patients whose calorie intake was not restricted (non-diet (ND) group). The daily oral calcium intake of the two groups did not differ significantly. We found no significant difference in the serum PTH level in the ND groupVS. normal control subjects (248.8±98.4, N=78). The serum calcium concentration and the amount of calcium excreted in urine were slightly but significantly (P<0.01) lower in the D than in the ND group. The rate of tubular reabsorption of phosphate (% TRP) was significantly lower in the D group than that in the ND group (P<0.01). The serum CTN level was significantly (P<0.01) lower in the D group (33.9±11.3 pg/ml) than in the ND group (64.9±21.2 pg/ml) 2 years after each treatment. The plasma 1,25-(OH)₂-vitamin D level was significantly (P<0.01) lower in the D group (22.2±6.6 pg/ml) than in the ND group (50.6±4.2 pg/ml). When the restriction of calorie intake in the D group was canceled, their PTH levels decreased, which was accompanied by increase in the 1,25-(OH)₂-vitamin D levels, whereas their CTN levels were unchanged. These observations suggested that a restricted calorie intake is a risk factor for secondary hyperparathyroidism as well as for a low serum level of CTN in patients with NIDDM.     

^99mTc—MIBI心肌断层显像潘生丁试验对缺血性心脏病诊断的评价

本文对４０例冠心病患者和３２例正常人在潘生丁药物负荷前、后进行＾９９ｍＴｃ－ＭＩＢＩ心肌断层显像的资料进行了分析。结合潘生丁药物负荷前、后的＾９９ｍＴｃ－ＭＩＢＩ心肌断层图像和靶心图可对冠心病心肌缺血或心肌梗塞的部位、范围及严重程度作出有意义的评价，并可观察左室腔的大小和室壁厚薄等情况。其诊断冠心病的灵敏性为９２．５％、特异性为８７．５％。本文发现早期冠心病负荷显像表现的缺血区在静息状态下显像大多