A retrospective study on the use of oral morphine in cancer pain

The authors report a retrospective study of 390 cancer pain patients tested with oral morphine during a four-month period. Initial pain scores were reduced to one half after one week of treatment and then maintained throughout the study period. Mean daily dosages of morphine were lower in those patients 65 years and older. No significant changes in performance in relation to therapy were noted except for an increase in hours of sleep. An accurate titration of dosage and continued control of side effects are the main requirements of this method of administration. The presence of side effects and the cause of interruption of treatment are reported.     

应用人自体血清培养人口腔黏膜上皮的实验研究

目的 研究人自体血清培养人口腔黏膜移植生长的生物学特性，为组织工程化尿道提供新材料。方法 将人自体血清培养黏膜移植于裸鼠体内，分别于移植后2、3、4、6周观察培养黏膜生长与转归，应用anti—HLA免疫荧光鉴定成活黏膜组织属性，应用抗人Ⅳ型胶原及抗人层黏蛋白为基底膜形成指标。结果 裸鼠体内移植培养黏膜成活生长分化良好，anti—HLA免疫荧光证实为移植的培养人黏膜组织；免疫组化发现移植后3周开始形成基底膜，4周形成完整的基底膜。结论 自体血清培养的人口腔黏膜可形成功能完整的上皮组织。     

小柴胡汤口服液药效作用的研究

观察了小柴胡汤口服液的主要药理作用。研究表明,小柴胡汤口服液有显著抑制角叉菜胶诱发的大鼠踝关节水肿(p<0.05),保护四氯化碳所致的大鼠急性肝功能损害,有极显著降低血清SGPT及LDH的作用(P<0.01)。对家兔发热反应也有较好的抑制作用。此外,小柴胡汤口服液对小鼠兔疫反应也有一定的增强作用,可促进小鼠碳粒廓清速率,提高血清溶血素水平及增强鸡红细胞所致的迟发性过敏反应。     

38例前牙反(牙合)的临床矫治体会

目的　探讨更有效矫治前反牙合的方法。方法　本文选择了 38例恒前牙反牙合、反覆牙合深而反覆盖浅、下牙列基本整齐、磨牙关系基本中性的病例 ,采用上颌方丝弓加下颌后牙牙合垫相结合的方法进行矫治。结果　平均 7个月完成矫治 ,并取得满意疗效。结论　对具有较深反覆牙合的恒前牙反牙合 ,采用上颌方丝弓与下颌后牙牙合垫相结合的方法矫治 ,明显的提高了矫治效率     

复方决明子口服液的制备工艺研究

目的 :用正交法优选复方决明子口服液的最佳工艺条件。方法 :以决明子中蒽醌的含量及浸出物的含量为指标 ,应用L9(3′)正交试验法优选复方决明子口服液的最佳工艺条件。结果 :最佳提取条件为 :加 1 0倍量水 ,煎煮 3次 ,每次 1 .5h。结论 :优越工艺验证表明 ,最佳提取工艺为A1 B2 C1 。说明优选工艺稳定可靠。     

功能性矫治器在正畸矫治中运用的伦理思考

功能性矫治器是正畸临床中常用的一种矫治器，作者从口腔正畸学理论基础出发，探讨了功能性矫治器在正畸矫治作用中存在的伦理道德问题，主要有（1）不能正确的诊断、制定周密的矫治计划。（2）操作不规范、不细致、缺乏敬业精神。（3）态度简单，粗曝，缺乏与患者良好的交流。并提出解决方法（1）刻苦学习专业知识，不断提高诊疗水平及个人修养。（2）建立高度的道德责任感，以严谨的作风，规范的操作为病人服务。（3）尊重、善待青少年，建立良好的医患关系。     

Failure of oral implants: aetiology, symptoms and influencing factors

The use of oral implants opened a wide range of prosthetic treatment possibilities in edentulous patients. Although the reported success rates of oral implants are high, failures do occur. This paper reviews the current knowledge about the aetiology, the signs and symptoms and the possible influencing factors of implant failure. Possible causes of implant failure are thought to be infection of the periimplant tissues, occlusal overload, or a combination of both. Nevertheless, pinpointing one of these as the aetiological factor in a particular case is difficult and should be handled reluctantly. Although the cause might seem obvious, influencing factors could play a role as well. Gaining insight into these processes might stimulate the adoption of preventive action and therefore increase the predictability of the treatment outcome with oral implants. Received: 4 April 1997 / Accepted: 27 November 1997     

Ultrastructure of lentigo maligna in the oral cavity

A rare case of lentigo maligna in the oral cavity was investigated by light and electron microscopy. Cutaneous lentigo malignas often develop to malignant melanomas. However, the electron microscopic examination revealed that even though there were a large number of melanosomes, most of them were late stage and had membrane structure, and positive staining with HMB-45 was not recognized. From our findings, it is difficult to conclude that oral lentigo malignas develop malignant melanomas, and thus further studies are needed.     

大肠菌群MPN检测法在药品微生物限度检查中的应用

采用大肠菌群作为卫生指示菌,对口服药品进行细菌学检验,实验结果表明有利于口服药品染菌状况的监督与控制。     

金锁匙口服液药效学及毒性研究

通过对金锁匙口服液的药效学及毒性的研究表明：本品能明显抑制吗啡依赖性小白鼠停药后的跳跃反应，协同戊巴比妥钠催眠作用，提高小鼠热板法痛阈值，抑制醋酸引起的小鼠扭体反应，提示金锁匙口服液对吗啡类成瘾患者有一定的治疗作用，毒理研究表明；本品服用无药物依赖性、安全、无毒。