全文获取类型
收费全文 | 221996篇 |
免费 | 29525篇 |
国内免费 | 7271篇 |
专业分类
耳鼻咽喉 | 1710篇 |
儿科学 | 2114篇 |
妇产科学 | 5310篇 |
基础医学 | 16699篇 |
口腔科学 | 2179篇 |
临床医学 | 19406篇 |
内科学 | 22357篇 |
皮肤病学 | 1450篇 |
神经病学 | 839篇 |
特种医学 | 7062篇 |
外国民族医学 | 272篇 |
外科学 | 31279篇 |
综合类 | 29199篇 |
现状与发展 | 39篇 |
一般理论 | 3篇 |
预防医学 | 10353篇 |
眼科学 | 131篇 |
药学 | 15126篇 |
145篇 | |
中国医学 | 5113篇 |
肿瘤学 | 88006篇 |
出版年
2024年 | 473篇 |
2023年 | 4470篇 |
2022年 | 6788篇 |
2021年 | 11983篇 |
2020年 | 11155篇 |
2019年 | 10158篇 |
2018年 | 9741篇 |
2017年 | 10055篇 |
2016年 | 10816篇 |
2015年 | 12461篇 |
2014年 | 18287篇 |
2013年 | 17873篇 |
2012年 | 14471篇 |
2011年 | 14784篇 |
2010年 | 10816篇 |
2009年 | 10995篇 |
2008年 | 11312篇 |
2007年 | 10703篇 |
2006年 | 9518篇 |
2005年 | 7863篇 |
2004年 | 6478篇 |
2003年 | 5451篇 |
2002年 | 4578篇 |
2001年 | 4223篇 |
2000年 | 3474篇 |
1999年 | 2960篇 |
1998年 | 2475篇 |
1997年 | 2206篇 |
1996年 | 1821篇 |
1995年 | 1660篇 |
1994年 | 1341篇 |
1993年 | 1053篇 |
1992年 | 910篇 |
1991年 | 837篇 |
1990年 | 628篇 |
1989年 | 562篇 |
1988年 | 489篇 |
1987年 | 454篇 |
1986年 | 347篇 |
1985年 | 418篇 |
1984年 | 349篇 |
1983年 | 237篇 |
1982年 | 248篇 |
1981年 | 232篇 |
1980年 | 181篇 |
1979年 | 140篇 |
1978年 | 96篇 |
1977年 | 73篇 |
1976年 | 65篇 |
1975年 | 40篇 |
排序方式: 共有10000条查询结果,搜索用时 25 毫秒
991.
R. A. Gardiner 《ANZ journal of surgery》1995,65(5):350-358
The principles of urology and all surgical disciplines were, not too long ago, considered to be rigidly and permanently established. In this exciting era of change, the foundations of urology are now set on shifting sands rather than the bedrock of the past. The pertinent issue clinically is making discriminating evaluations of new developments so that, where appropriate. they are able to be incorporated into treatment practices to improve patient care. In this overview, a personal appreciation of the more important practical and conceptual changes relating to prostatic. urothelial and renal carcinoma during the past 5 to 10 years is presented. 相似文献
992.
聚合酶链反应单链构象多态性检测乳腺癌中P53基因突变 总被引:4,自引:0,他引:4
应用聚合酶链反应单链构象多态性方法,对24例原发性乳腺癌肿瘤组织基因组DNA进行了分析,结果表明:其中7例存在P53基因的突变,突变频率约为30%。同时对其中10例进行Souternblot分析,有2例在chr17P上存在等位基因的缺失,而其另一等位基因上均存在基因突变。 相似文献
993.
E. Rigotti G. L. Piacentini M. Ress R. Pigozzi A. L. Boner D. G. Peroni 《Clinical and experimental allergy》2006,36(5):614-618
BACKGROUND: Precise relationship between breastfeeding and infant allergy is poorly understood. Objective Aim was to quantify TGF-beta(1) and IL-10 in colostrum and mature milk from allergic and non-allergic mothers and to verify relationship with allergic disease development. METHODS: Mothers (13 allergics, nine controls) of 22 newborns participated to prospective study on development of children atopy. Colostrum and mature milk were assayed for TGF-beta(1) and IL-10 by ELISA. Children underwent paediatrician evaluation at 6 months of life. RESULTS: Data are presented as median values and range. A significant difference in concentration of TGF-beta(1) between colostrum (330, range 0-3400 pg/mL) and mature milk (215, range 0-2400 pg/mL) was observed in samples from allergic mothers (P=0.015). In mature milk TGF-beta(1) was significantly lower in allergic (215, range 0-2400 pg/mL) than in non-allergic mothers (1059, range 0-6250 pg/mL) (P=0.015). IL-10 was weakly expressed without significant differences between allergic (4.8, range 0-42 and 9.5, range 0-42 pg/mL in colostrum and in mature milk) and non-allergic mothers (0, range 0-42 pg/mL in colostrum and 0, range 0-42 pg/mL in mature milk). After 6 months 46% infants from allergic mothers, but none from controls, presented atopic dermatitis. CONCLUSION: TGF-beta(1) was significantly less secreted in mature milk of allergic mothers, while no difference in IL-10 was found. Particular cytokine patterns in milk could influence development of atopic diseases. Further immunological studies in this field are necessary. 相似文献
994.
目的 探讨乳腺癌内乳淋巴结转移的高危因素。方法回顾性分析复旦大学附属肿瘤医院乳腺外科1956-2003年开展的l679例乳腺癌扩大根治术临床资料,选取病人年龄、肿瘤大小、肿瘤位置、腋窝淋巴结转移状况共4个乳腺癌内乳淋巴结转移可能相关的因素,分析不同情况下内乳淋巴结转移的高危因素。结果在选取的4个因素中,肿瘤大小不是影响内乳淋巴结转移的独立因素。腋窝淋巴结状况为内乳淋巴结转移的重要影响因素。不同情况下,肿瘤位置和年龄对内乳淋巴结转移的影响也不同。腋窝淋巴结阴性病人的内乳淋巴结转移率为4.4%,腋窝淋巴结1-3个阳性为18.8%,腋窝淋巴结4-6个阳性为28.1%,腋窝淋巴结≥7个为41.5%。结论有4个或以上腋窝淋巴结转移、内侧肿瘤合并腋窝淋巴结转移、肿瘤直径〉5.0cm的年轻病人是内乳淋巴结转移率的高危病人。 相似文献
995.
乳腺癌组织中Cyclin D1及p16蛋白表达的联合检测及其意义 总被引:3,自引:1,他引:2
目的:探讨乳腺癌中Cyclin D1及p16蛋白表达的相关性及其临床意义。方法:LSAB法检测多种乳腺组织中Cyclin D1及p16蛋白的表达情况,结合有关临床资料,分析Cyclin D1和p16蛋白表达异常与乳腺癌中重要的临床病理因素的关系。结果:62例乳腺癌组织中,Cyclin D1蛋白过度表达占48·4%,其表达与乳腺癌组织学分级呈明显正相关,且Cyclin D1蛋白过度表达更常见于ER、PR阳性的乳腺癌中。乳腺癌旁组织中Cyclin D1蛋白过度表达为20·0%,其他几种乳腺组织很少有CyclinD1蛋白的过度表达。p16蛋白仅在58·1%的乳腺癌组织中有表达,且p16的表达与组织学分级程度有负相关关系。正常乳腺组织中未见p16蛋白的异常。结论:乳腺癌组织中存在着Cyclin D1蛋白的过度表达及p16蛋白的异常,二者对乳腺癌组织的增殖分化有一定的影响。 相似文献
996.
DAISUKE ISHII AKIRA IRIE KAZUMASA MATSUMOTO TAKANORI TOJO YOSHINORI TAOKA MASATSUGU IWAMURA KAZUNARI YOSHIDA SHIRO BABA 《International journal of urology》2006,13(7):1009-1011
Laparoscopic cystectomy and bilateral ureteric ligation were performed on a 52-year-old woman with end-stage renal disease on hemodialysis (HD) for muscle-invasive bladder cancer. Her volume of urine production was approximately 100 mL/day. Excisions of the bladder and uterus with ligation of the bilateral ureter were conducted completely laparoscopically. Total operative time was 280 min and the amount of blood loss was 60 mL. No complications were seen perioperatively and no adverse events regarding ureteric ligation arose. HD was performed on the second postoperative day. At a 12-month follow-up, the patient showed no evidence of disease. 相似文献
997.
998.
999.
目的:探讨原发性高血压(EH)患者血浆中肾上腺髓质素前体N端20肽(PAMP)与左室肥厚的相互关系。方法:观察62例EH患者血浆PAMP的变化以及与左室重量指数之间的关系。结果:经超声心动图检查显示,62例EH患者中伴左室肥厚者42例,无左室肥厚患者20例。EH伴左室肥厚患者血浆PAMP浓度较无左室肥厚患者明显增高(65·8±12·0)∶(60·8±9·0)ng/L,P<0·05。结论:EH患者血浆PAMP的升高可能为机体的代偿反应,有助于改善患者的预后。 相似文献
1000.
Y. SUZUKI† T. NAKANO† T. OHNO† S. KATO Y. NIIBE S. MORITA & H. TSUJII 《International journal of gynecological cancer》2006,16(1):306-311
The presence of hypoxic cells is one of the major factors affecting resistance against radiation therapy. In the clinical setting, little information exists as to the relationship between intratumoral oxygen partial pressure (pO(2)) and outcome. This study involved 30 consecutive patients with cervical cancer, who were treated with a combination of external and high-dose rate intracavitary irradiation. The pO(2) was measured before radiation therapy and at 9 Gy, using a needle-type polarographic oxygen electrode. The mean intratumoral pO(2) before radiation therapy was 17.3 +/- 10.8 mm Hg. The 3-year local control rates of patients with pO(2)< or = 20 mm Hg and pO(2) > 20 mm Hg before radiation therapy were 52% and 100%, respectively, representing a significant difference (P= 0.035). At 9 Gy, mean intratumoral pO(2) was 23.6 +/- 9.1 mm Hg, a significant increase compared to the value before radiation therapy (P= 0.006). The 3-year local control rates of tumors with pO(2)< or = 20 mm Hg and pO(2) > 20 mm Hg at 9 Gy were 35% and 93%, respectively, representing a significant difference (P= 0.001). The significantly better local control for oxygenated tumors at 9 Gy as well as before radiation therapy indicated that the oxygen effect and reoxygenation by radiation played an important role in local control in radiation therapy for cervical cancer. 相似文献