全文获取类型
收费全文 | 1559篇 |
免费 | 44篇 |
国内免费 | 69篇 |
专业分类
耳鼻咽喉 | 76篇 |
儿科学 | 23篇 |
妇产科学 | 21篇 |
基础医学 | 228篇 |
口腔科学 | 36篇 |
临床医学 | 126篇 |
内科学 | 231篇 |
皮肤病学 | 74篇 |
神经病学 | 83篇 |
特种医学 | 83篇 |
外科学 | 148篇 |
综合类 | 156篇 |
预防医学 | 66篇 |
眼科学 | 48篇 |
药学 | 146篇 |
中国医学 | 26篇 |
肿瘤学 | 101篇 |
出版年
2023年 | 28篇 |
2022年 | 38篇 |
2021年 | 60篇 |
2020年 | 40篇 |
2019年 | 49篇 |
2018年 | 38篇 |
2017年 | 43篇 |
2016年 | 56篇 |
2015年 | 42篇 |
2014年 | 94篇 |
2013年 | 73篇 |
2012年 | 88篇 |
2011年 | 104篇 |
2010年 | 72篇 |
2009年 | 93篇 |
2008年 | 78篇 |
2007年 | 67篇 |
2006年 | 69篇 |
2005年 | 67篇 |
2004年 | 43篇 |
2003年 | 42篇 |
2002年 | 47篇 |
2001年 | 42篇 |
2000年 | 25篇 |
1999年 | 22篇 |
1998年 | 21篇 |
1997年 | 23篇 |
1996年 | 17篇 |
1995年 | 13篇 |
1994年 | 19篇 |
1993年 | 15篇 |
1992年 | 16篇 |
1991年 | 14篇 |
1990年 | 15篇 |
1989年 | 7篇 |
1988年 | 8篇 |
1987年 | 13篇 |
1986年 | 7篇 |
1985年 | 17篇 |
1984年 | 8篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 6篇 |
1980年 | 11篇 |
1979年 | 6篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1972年 | 2篇 |
1969年 | 1篇 |
排序方式: 共有1672条查询结果,搜索用时 281 毫秒
31.
Magnetic resonance imaging and histopathology of cerebral gliomas 总被引:22,自引:1,他引:21
Summary The correlation of magnetic resonance imaging (MRI) with histopathological findings was analysed in 26 patients with untreated cerebral gliomas. In low-grade gliomas, T2-weighted images demonstrated relatively homogeneous high-intensity lesions involving both the grey and the white matter. In high-grade gliomas, especially grade IV, T2-weighted images demonstrated prominent heterogeneity in signal intensity, which consisted of a hyperintense core, less hyperintense or normal intensity rim and surrounding finger-like areas of high intensity. Marked and irregular contrast enhancement was evident in all but one case of these high-grade gliomas in which gadolinium-DTPA was used. Histological examination revealed tumour cells extending as far as the borders of the high-intensity areas shown on T2-weighted images in both high-and low-grade gliomas, but in 5 of 8 low-grade and 4 of 18 high-grade gliomas, isolated tumour cells extended beyond the hyperintense areas shown on T2-weighted images. 相似文献
32.
Summary Muscle biopsies of two patients originally reported in the Göttingen family by Becker (1962) that formed the basis of separating a benign X-linked muscular dystrophy from the rapidly progressive Duchenne-type X-linked muscular dystrophy, revealed mild pathological changes in the younger patient and more advanced in the older one, consisting of increased spectra of fiber diameters, endomysial fibrosis, angulated fibers, pyknotic nuclear clumps and small groups of atrophic fibers. Essentially, both biopsies showed the same changes, but of different severity, possibly due to the differences in age and muscle biopsy sites. These changes were regarded myopathic, but a neurogenic component was suggested. Our observations accord well with those of a larger series (Bradley et al., 1978) where both electromyography and histopathology revealed a mixed myopathic-neurogenic pattern in patients with Becker-type dystrophy. Differential diagnostic aspects encompass Duchenne's muscular dystrophy, the other hereditary dystrophies and X-linked proximal spinal muscular atrophies. The precise nature of Becker-type muscular dystrophy requires morphological data on peripheral nerves, spinal roots and spinal cord anterior horn cells as well as sequential biopsy analysis to substantiate the primary site of pathology. However, on the basis of available data, it seems reasonable to suggest that the early changes of degeneration/regeneration which are accompanied by a markedly elevated CPK eventuate in the histopathologic and electromyographic patterns illustrated in these two patients with Beckertype dystrophy.These studies have in part been supported by a grant from The Volkswagen-Stiftung (HHG). Parts of this paper have been presented at the Neurochemical Group Symposium, Bath University, March 30, 1977, and at the Annual Meeting of the German Society of Neuropathology, Tübingen University, October 17–19, 1977 相似文献
33.
目的 探索氩氮靶向冷冻治疗系统(氩氮刀)在脑胶质瘤治疗中的应用价值。方法 开颅后,根据MRI及CT设计冷冻范围,应用氩氮刀冷冻-复温-冷冻后切除胶质瘤,并取冷冻前后标本送病理检查。结果 8例Ⅱ~Ⅳ级胶质瘤患者肿瘤均达到全切,术中出血少,术后短期未见副作用及神经功能缺失。冷冻前后病理切片对比:与冷冻前对比,冷冻后标本在普通显微镜下见有明显出血灶;透射电镜下可见几乎所有细胞核膜肿胀,核形状不规则,染色质凝结为粗颗粒状,明显边聚,线粒体明显肿胀,部分破裂崩解。结论氩氮靶向冷冻治疗系统治疗脑胶质瘤具有能直接摧毁肿胀细胞、手术安全、出血少、全切率高的优点。 相似文献
34.
35.
36.
Yasuhiro Takahashi Emiko Takahashi Yuji Hiromatsu 《Modern rheumatology / the Japan Rheumatism Association》2018,28(5):893-896
We report two cases with immunoglobulin G4 (IgG4)-positive staining of orbital lesions and thyroid eye disease (TED). Case 1 was a 63-year-old male with right upper eyelid swelling due to right lacrimal gland enlargement. Case 2 was a 49-year-old male with bilateral proptosis due to multiple orbital masses. Both the biopsied right lacrimal gland in Case 1 and the orbital masses on both sides in Case 2 showed infiltration of immunoglobulin-G4-positive plasma cells. 相似文献
37.
Histopathological evaluation of duodenal biopsy in the PreventCD project. An observational interobserver agreement study 下载免费PDF全文
Vincenzo Villanacci Luisa Lorenzi Francesco Donato Renata Auricchio Piotr Dziechciarz Judit Gyimesi Sibylle Koletzko Zrinjka Mišak Vanesa Morente Laguna Isabel Polanco David Ramos Raanan Shamir Riccardo Troncone Sabine L. Vriezinga M. Luisa Mearin 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2018,126(3):208-214
Aim of the current study was to evaluate the inter‐observer agreement between pathologists in the diagnosis of celiac disease (CD), in the qualified context of a multicenter study. Biopsies from the “PreventCD” study, a multinational‐ prospective‐ randomized study in children with at least one‐first‐degree relative with CD and positive for HLA‐DQ2/HLA‐DQ8. Ninety‐eight biopsies were evaluated. Considering diagnostic samples with villous atrophy (VA), the agreement was satisfactory (κ = 0.84), but much less when assessing the severity of these lesions. The use of the recently proposed Corazza‐Villanacci classification showed a moderately higher level of agreement (κ = 0.39) than using the Marsh‐Oberhuber system (κ = 0.31). 57.1% of cases were considered correctly oriented. A number of >4 samples per patient was statistically associated to a better agreement; orientation did not impact on κ values. Agreement results in this study appear more satisfactory than in previous papers and this is justified by the involvement of centers with experience in CD diagnosis and by the well‐controlled setting. Despite this, the reproducibility was far from optimal with a poor agreement in grading the severity of VA. Our results stress the need of a minimum of four samples to be assessed by the pathologist. 相似文献
38.
39.
《亚太生殖杂志》2014,3(1):8-12
ObjectiveTo evaluate the safety & efficacy of Maa-Lact granules for its galactogougue activity in Holtzman rats and its effect on suckling pups.MethodsGroup I rats were treated as control, group II and III rats were treated with 500 mg/kg, 1 000 mg/kg of Maa-Lact granules for 21 days. Weekly body weights of dams and pups were collected, litter survivability for 22 days and ocular blood samples were collected on 1st day of parturition and 21st day of post parturition for the estimation of prolactin levels. On 21st day blood samples were collected from retro-orbital sinus for haemotological and biochemical estimations. On the same day of weaning rats were sacrificed and subjected to necropsy and individual organ weights were recorded.ResultsNo significant difference in weekly food weight consumption, body weights between control & treated groups with normal clinical signs. There is no mortaly in dams throught the study period with no significant difference in pups weights. The percentage mortality in pups was 14.43 %, 14.07 %, and 13.42% in group I, group II and group III, respectively. The histopathological finding has shown that treated groups have less convulution and adipose tissue deposition along with increase in length and branching of lactiferous duct and alveolar size.ConclusionBased on above results, it can be concluded that Maa-Lact posseses significant galctogogue activity. 相似文献
40.
In this study, biochemical changes and histological structure of rat liver after bendiocarb administration and possible preventive effects of vitamins C and E were studied. The animals were given with bendiocarb, vitamin C and vitamin E, daily 0,8 mg/kg of body weight (bw), 100 mg/kg-bw and 100 mg/kg-bw for 28 days, respectively. Lipid peroxidation, antioxidant enzyme activities, histological alterations and antioxidant capacity assays of liver and also liver function tests and lipid profile were measured. Bendiocarb treatment decreased the antioxidant enzyme activities, FRAP and TEAC values and increased malondialdehyde levels compared to control. Also, there were statistically significant alterations in liver function tests, lipid profile parameters and histopathological changes in bendiocarb treated groups. Vitamins C and E showed protective effects against examining parameters. According to results we can say that co-treatment of vitamin C and vitamin E may be more effective than use of them alone. 相似文献