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61.
Intrauterine growth restriction is known to be associated with many medical problems for the baby, both before and after delivery. The mechanisms involved in fetal growth are not well understood, with an increasing range of metabolic diseases being implicated. Several key genes involved in normal embryonic and fetal growth and development are now known to be imprinted. Disruption of this parent-specific mono-allelic expression causes phenotypic changes, many of which are important for growth and development. Two growth disorders, Beckwith–Wiedemann syndrome and Silver–Russell syndrome, are discussed in detail as they represent well-characterized phenotypes that arise as a consequence of disrupted imprinting. These human models will allow us to elucidate key genes and mechanisms important in normal fetal growth. 相似文献
62.
第一产程异常胎心监护图形与新生儿结局的关系 总被引:11,自引:0,他引:11
目的 探讨第一产程异常胎心监护图形与新生儿结局的关系。方法 回顾分析 2 0 0 2年 8月至 2 0 0 3年 6月在我院足月单胎头位分娩产妇 ,第一产程中胎心率 (FHR)异常图形 2 1 7例 (观察组 )和FHR正常图形的2 6 9例 (对照组 )的临床资料。结果 第一产程异常FHR图形的发生率为 4 4 7% ,常见类型为轻度变异减速(6 4 5 % )、基线变异减弱 (2 1 6 % )和轻度心动过速 (1 2 0 % )。晚期减速、基线变异减弱和重度变异减速是导致新生儿窒息的危险因素。观察组羊水过少 (5 1 % )、脐带缠绕 (2 2 6 % )、羊水粪染 (1 0 6 % )、新生儿窒息 (6 5 % )、新生儿转入NICU(1 0 1 % )的发生率和剖宫产率 (31 8% )明显高于对照组 (P <0 0 5 )。结论 第一产程异常FHR图形的发生率较高 ,其中晚期减速、基线变异减弱、重度变异减速与新生儿窒息的发生相关 ,其他图形可在严密监护下继续试产 相似文献
63.
新生儿脐血红细胞葡萄糖6磷酸脱氢酶缺乏筛查结果分析 总被引:4,自引:0,他引:4
目的 了解广东省东莞市莞城地区新生儿脐血红细胞葡萄糖6磷酸脱氢酶(G-6-PD)缺乏的发生率。方法 9676例活产新生儿生后即取脐血,采用定量法测定红细胞G6PD/6PGD的比值。低于1.0者为G-6-PD缺乏。结果 测得G-6-PD缺乏的患儿265例,总发生率为2.74%。其中男230例,发生率为4.07%;女35例,发生率为0.87%。男性发生率明显高于女性(χ^2=90.75,P<0.001)。结论 脐血G-6-PD活性筛查,能比较准确地检测出G-6-PD缺乏患儿,指导临床对其并发症进行早期干预,避免智力低下等后遗症的发生,提高人口素质。 相似文献
64.
W. Andonotopo M. Stanojevic A. Kurjak G. Azumendi JM Carrera 《The Ultrasound Review of Obstetrics & Gynecology》2004,4(2):103-114
The aim of this paper was to review the clinical applications of four-dimensional ultrasonography in the assessment of fetal behavior. With the use of a computerized database, articles on three-dimensional ultrasonography were reviewed. Several applications of dynamic three-dimensional ultrasonography have been reported, including imaging of fetal movements, facial expression and fetal hand movements. The importance of the assessment of fetal behavior by four-dimensional sonography is stressed. Four-dimensional sonography seems to be a useful imaging tool for clinical problem solving in perinatology, especially in observing the development of the central nervous system in utero. 相似文献
65.
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67.
Pam Loughna 《Current Obstetrics & Gynaecology》2006,16(2):107-110
68.
Objective To assess the effect of lung protective ventilation on outcome of children with acute respiratory distress syndrome(ARDS).Methods Between January 1999 and December 2007,43 children with ARDS were enrolled from PICU of Shanghai Children's Medical Center and assigned to the protective-ventilation group(group A) or the conventional-ventilation group(group B).The patients in group A (from January 2004 to December 2007)received lower tidal volume(6~7 ml/kg) and high levels of positive end-expiratory pressure(PEEP),and optimal oxygenation was achieved by adjusting FiO2 and PEEP.The patients in group B(from January 1999 to December 2003) received relatively higher tidal volume(8~12 mL/kg) with lower PEEP(2~6 cm H2O),and optimal oxygenation was achieved by adjusting FiO2.Tidal volume,PEEP,arterial blood gas,mortality and the number of ventilator-free days were compared between the two groups.Results Since protective ventilation was adopted after 2004,tidal volume was significantly lower in group A[(7.09±1.66)ml/kg]as compared with that in group B[(9.82±2.31) ml/kg](P=0.001).PEEP was significantly higher in group A[(7.15±2.08) cm H2O]as compared with that of group B[(5.40 + 1.84) cm H2O](P=0.021).The mortality was 30.3% in group A and 60.0% in group B.The number of ventilator-free days were(10.88±8.84) d in group A and(8.40±10.86) d in group B.Although mortality was lower and number of ventilator-free days was greater in group A,no significant differences were found between the two groups(P>0.05).Conclusion Lung protective ventilation may improve the outcome for pediatric patients with ARDS,however,larger trials are required before a definite conclusion can be reached. 相似文献
69.
Belek I 《Social psychiatry and psychiatric epidemiology》2000,35(2):94-101
Aim: The aim of this study is to determine the separate effects of social class, income, education and area of residence on psychological
distress. The study also assesses whether the association between prevalence of high score on the 12-item General Health Questionnaire
(GHQ 12) and social class is independent of other variables. Method: Psychological distress was assessed by means of the GHQ 12. The study covered 1092 adults aged 15 years or more living in
two different quarters of Antalya. Social class status was defined by occupational position, with income, education and area
of residence treated as confounders. Chi-square and logistic regression analyses were used to evaluate the data. Results: Large inequalities in psychological distress by all variables were observed. Psychological distress was significantly associated
with class status, after adjusting for income, education, area of residence and other potential confounders (age, sex and
marital status). Class inequalities in psychological distress were observed between blue-collar workers/unqualified employees
and bourgeoisie. Conclusions: These findings support the view that the recent widening of inequalities among social classes in Turkey pose a substantial
threat to health.
Accepted: 5 November 1999 相似文献
70.