全文获取类型
收费全文 | 63665篇 |
免费 | 4421篇 |
国内免费 | 2091篇 |
专业分类
耳鼻咽喉 | 246篇 |
儿科学 | 887篇 |
妇产科学 | 736篇 |
基础医学 | 7923篇 |
口腔科学 | 811篇 |
临床医学 | 5063篇 |
内科学 | 14438篇 |
皮肤病学 | 830篇 |
神经病学 | 3376篇 |
特种医学 | 1261篇 |
外国民族医学 | 291篇 |
外科学 | 4395篇 |
综合类 | 9541篇 |
现状与发展 | 5篇 |
预防医学 | 4663篇 |
眼科学 | 932篇 |
药学 | 8597篇 |
6篇 | |
中国医学 | 3245篇 |
肿瘤学 | 2931篇 |
出版年
2023年 | 449篇 |
2022年 | 654篇 |
2021年 | 1233篇 |
2020年 | 1200篇 |
2019年 | 1891篇 |
2018年 | 1962篇 |
2017年 | 1667篇 |
2016年 | 1647篇 |
2015年 | 1815篇 |
2014年 | 6625篇 |
2013年 | 5869篇 |
2012年 | 4625篇 |
2011年 | 4564篇 |
2010年 | 5326篇 |
2009年 | 4903篇 |
2008年 | 3108篇 |
2007年 | 2364篇 |
2006年 | 2031篇 |
2005年 | 1783篇 |
2004年 | 1569篇 |
2003年 | 1447篇 |
2002年 | 1222篇 |
2001年 | 1094篇 |
2000年 | 933篇 |
1999年 | 843篇 |
1998年 | 720篇 |
1997年 | 774篇 |
1996年 | 581篇 |
1995年 | 578篇 |
1994年 | 502篇 |
1993年 | 380篇 |
1992年 | 335篇 |
1991年 | 261篇 |
1990年 | 201篇 |
1989年 | 179篇 |
1988年 | 150篇 |
1987年 | 131篇 |
1985年 | 466篇 |
1984年 | 565篇 |
1983年 | 453篇 |
1982年 | 418篇 |
1981年 | 406篇 |
1980年 | 363篇 |
1979年 | 324篇 |
1978年 | 276篇 |
1977年 | 208篇 |
1976年 | 247篇 |
1975年 | 250篇 |
1974年 | 196篇 |
1973年 | 174篇 |
排序方式: 共有10000条查询结果,搜索用时 718 毫秒
101.
本研究经杀菌试验和免疫后保护力试验探讨小鼠巨噬细胞在抗白色念珠菌感染中的作用,结果表明白色念珠菌酵母形体对巨噬细胞杀伤作用的抵抗力及对小鼠的毒力均较菌丝形体强。小鼠体内不同部位巨噬细胞杀伤白色念珠菌的作用不同,脾脏巨噬细胞作用大于腹腔残存巨噬细胞。经白色念珠菌活菌静脉免疫后脾巨噬细胞杀白色念珠菌作用增强,但其对再感染的抵抗力不增强。 相似文献
102.
103.
Papillitis and vasculitis of the arteria spinalis anterior as complications of hepatitis C reinfection after liver transplantation 总被引:1,自引:0,他引:1
T. Propst Albert Propst Karin Nachbaur I. Graziadei Hans Willeit Raimund Margreiter Wolfgang Vogel 《Transplant international》1997,10(3):234-237
It is well known that hepatitis C virus (HCV)-related chronic liver disease may be associated with various immunological
disorders including mixed cryoglobulinemia, which is accompanied by cutaneous vasculitis, arthralgias, membranoproliferative
glomerulonephritis, and neuropathy in association with cryoprecipitable immune complexes in serum. We describe here the first
case of central nervous system HCV infection with evidence of the virus in the cerebrospinal fluid in association with cryoglobulinemia
in a patient who developed recurrent episodes of papillitis and vasculitis of the arteria spinalis anterior after liver transplantation.
Received: 3 September 1996 Received after revision: 13 November 1996 Accepted: 6 December 1996 相似文献
104.
Dario Roccatello Marco Formica Guido Cavalli Maria C. Amprimo Maria G. Pignatelli Paolo Costa Ruggero de Paulis Giacomo Quattrocchio rea Molino Gianbeppe Giordano 《Artificial organs》1990,14(1):69-72
Neutrophil oxidative metabolism, C3d and beta 2 microglobulin levels, were assessed in nine consecutive patients undergoing cardiopulmonary bypass surgery with polypropylene hollow fiber oxygenators for open cardiac operations. Generation of oxygen free radicals by neutrophils was measured as luminol-enhanced chemiluminescence after stimulation with opsonized Zymosan and phorbol myristate acetate. A significant increase in light emission was detected by using both of the chemiluminescence stimulators. Moreover, a remarkable and significant increase in C3d levels was found already at 10 min. Conversely minimal changes in levels of beta 2 microglobulin were detected during cardiopulmonary bypass surgery. These data suggest that the impact of the patient blood with the foreign surface of cardiopulmonary bypass results in activation of phagocyte cells with increased potential in oxygen consumption. These effects could be partially complement-mediated. 相似文献
105.
Jean-yves Gillon Pierre-Alain Vitte Francoise Lemonnier Gabor Kato 《Drug development research》1994,32(1):42-49
Medifoxamine, an antidepressant agent which has an original chemical structure, has been shown through in vitro studies, utilising radioligand binding in tissue homogenates, to bind with moderately high affinity to 5-HT1c and 5-HT2 receptor subtypes and to 5-HT uptake sites (IC50 950, 980, and 1,500 nM, respectively). It has been shown to bind in vivo to rat brain 5-HT2 receptors after acute treatment with high dose (50 mg/kg, i.e., 133.9 μmol/kg). After 14 days continuous treatment with low dose (20 mg/kg, 53.6 μmol/kg), a decrease in the capacity of [3H]-5-HT uptake and a dose-dependent down-regulation of 5-HT2 receptors in rat cerebral cortex were observed. These results indicate that medifoxamine, which has been shown previously to act through dopaminergic systems, interacts also with central serotonergic neurotransmission and particularly with the 5-HT2 receptors, which could contribute to its antidepressant effect. 相似文献
106.
K. E. Anderson A. M. Dart E. A. Woodcock 《Clinical and experimental pharmacology & physiology》1994,21(2):141-144
1. Global myocariial ischaemia (MI) for periods greater tan 5 min caused an inhibition of phosphatidylinositol specific phospholipase C (PtdIns-PLC) activity. 2. Two min reperfusion following a 20 min MI period, a time point associated with reperfusion-induced arrhythmias, resulted in an activation of PtdIns-PLC activity, dependent on endogenous noradrenaline and mediated via al-adrenoceptors. 3. This 2 min reperfusion response, in contrast to healthy myocardium, resulted in: (i) enhanced PtdIns-PLC activity; (ii) increased sensitivity to endogenous noradrenaline; (iii) rapid increases in inositol(1,4,5)trisphosphate (Ins(1,4,5)P3); and (iv) PLC hydrolysis primarily of PtdIns(4,5)P2, such that the majority of InsP isomers derive from Ins(1,4,5)P3. 4. Together, these data suggest a functional role for Ins(1,4,5)P3 under postischaemic reperfusion conditions, and provide a possible link between al-adrenoceptor stimulation of the PtdIns turnover pathway and reperfusion injury. 相似文献
107.
应用国产ELISA试剂盒对157例肝癌、肝硬化病人血清中抗-HCV及HBV-M进行检测,101例肝癌10例抗-HCV阳性,阳性率为9.9%;56例肝硬化6例抗-HCV阳性,阳性率为10.7%;肝癌组抗HCV与HBsAg双阳性率79%(8/101),HBsAg阳性率为723%(73/101),明显高于HCV感染率,说明HBV仍是乙肝流行地区的主要相关因素。14例抗-HCV阳性(包括可疑阳性),肝癌外周血中8例(57.1%)HBsAg阳性,推测HCV可单独作用但更常与HBV形成混合感染参与慢性肝病的癌变过程。 相似文献
108.
杨兴旺 《眼外伤职业眼病杂志》1994,16(3):202-204
采用综合治疗,抗炎,散瞳,局部治疗与全身应用免疫抑制疗法,治疗319例352眼外伤获得了满意的疗效,眼球挫伤104例,眼球穿孔伤93例,化学烧伤71例,眼炸伤46例。眼热烧伤5例,治疗包括及时清创胶粘或缝合,清除前房出血合理用皮质类固醇和免疫抑制剂等。眼球挫伤治愈率97.12%,穿透伤93.18%,热烧伤66.67%。319例眼外伤治愈率94.67%好转5.33%,并对各种治疗方法进行了讨论。 相似文献
109.
Detection of hepatocellular carcinoma after interferon therapy for chronic hepatitis C: Clinical study of 26 cases 总被引:1,自引:0,他引:1
NOBUYUKI SUGIURA YUZOH SAKAI MASAAKI EBARA HIROYUKI FUKUDA MASAHARU YOSHIKAWA HIROMITSU SAISHO MASAO OHTO FUKUO KONDO 《Journal of gastroenterology and hepatology》1996,11(6):535-539
The clinical findings in 26 patients in whom hepatocellular carcinoma (HCC) was detected after the start of interferon (IFN) therapy for chronic hepatitis C were analysed. Histological study before IFN therapy showed that 34.6% of patients were categorized as stage 3 (septal fibrosis with architectural distortion; the 0–4 scale) and 80.8% demonstrated at least some evidence of septal fibrosis or more advanced features. The AFP levels examined before IFN therapy were more than 20 ng/mL in 13 patients (84.6% of those studied). One of 26 patients had a complete response to IFN therapy, while six of 26 patients had only a partial response. HCC was detected within 1 year after the start of IFN therapy in 76.9% of patients. Thus, the possibility of the early occurrence of HCC or its existence at the time of therapy should be seriously considered when IFN therapy is contemplated. Patients with stage 3 or 3–4 histology may already have a small undetectable HCC before IFN therapy. Thus, for this reason, every patient treated with IFN should be examined at short regular intervals for the development of HCC during and after IFN therapy. 相似文献
110.
目的:通过研究丙型肝炎病毒高变区1(HCV HVR1)准种复杂性与基因型之间的关系,探讨不同基因型HCV致病性差异的机制.方法:采用C区型特异性引物PCR法进行HCV基因分型,采用单链构象多态性聚合酶链反应法(SSCP法)检测HCV HVR1准种.结果:68例丙型肝炎患者中,Ⅱ型49例(72%),Ⅲ型13例(19%),Ⅱ、Ⅲ混合型6例(9%).Ⅱ型和Ⅱ、Ⅲ混合型HCV感染患者的HCV HVR1准种复杂性(SSCP条带数)明显高于Ⅲ型感染的患者,且与疾病严重程度关系密切.结论:HCV HVR1准种复杂性的差异可能是导致不同基因型HCV致病性差异的因素之一. 相似文献