全文获取类型
收费全文 | 102735篇 |
免费 | 10114篇 |
国内免费 | 2486篇 |
专业分类
耳鼻咽喉 | 978篇 |
儿科学 | 3779篇 |
妇产科学 | 1063篇 |
基础医学 | 8000篇 |
口腔科学 | 1064篇 |
临床医学 | 13769篇 |
内科学 | 15373篇 |
皮肤病学 | 726篇 |
神经病学 | 18738篇 |
特种医学 | 2980篇 |
外国民族医学 | 2篇 |
外科学 | 8151篇 |
综合类 | 15452篇 |
现状与发展 | 5篇 |
一般理论 | 1篇 |
预防医学 | 7678篇 |
眼科学 | 1084篇 |
药学 | 9459篇 |
109篇 | |
中国医学 | 5273篇 |
肿瘤学 | 1651篇 |
出版年
2024年 | 291篇 |
2023年 | 2037篇 |
2022年 | 3212篇 |
2021年 | 5282篇 |
2020年 | 5112篇 |
2019年 | 4334篇 |
2018年 | 3991篇 |
2017年 | 4436篇 |
2016年 | 4466篇 |
2015年 | 3918篇 |
2014年 | 7042篇 |
2013年 | 8015篇 |
2012年 | 5690篇 |
2011年 | 6305篇 |
2010年 | 5103篇 |
2009年 | 4803篇 |
2008年 | 4940篇 |
2007年 | 4987篇 |
2006年 | 4323篇 |
2005年 | 3653篇 |
2004年 | 2972篇 |
2003年 | 2639篇 |
2002年 | 2257篇 |
2001年 | 1964篇 |
2000年 | 1582篇 |
1999年 | 1375篇 |
1998年 | 1250篇 |
1997年 | 1122篇 |
1996年 | 940篇 |
1995年 | 916篇 |
1994年 | 807篇 |
1993年 | 647篇 |
1992年 | 696篇 |
1991年 | 572篇 |
1990年 | 489篇 |
1989年 | 431篇 |
1988年 | 406篇 |
1987年 | 365篇 |
1986年 | 270篇 |
1985年 | 308篇 |
1984年 | 272篇 |
1983年 | 177篇 |
1982年 | 224篇 |
1981年 | 139篇 |
1980年 | 107篇 |
1979年 | 110篇 |
1978年 | 111篇 |
1977年 | 59篇 |
1976年 | 65篇 |
1975年 | 42篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
101.
102.
Joseph M. Northey Kate L. Pumpa Clare Quinlan Ashley Ikin Kellie Toohey Disa J. Smee Ben Rattray 《Journal of Science and Medicine in Sport》2019,22(5):580-585
Objectives
The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.Design
Pilot randomised-controlled trial.Methods
Seventeen female cancer survivors (mean: 62.9 ± 7.8 years) were randomised into three groups: high-intensity interval training (HIIT, n = 6); moderate-intensity continuous training (MOD, n = 5); or wait-list control (CON, n = 6). The HIIT and MOD groups exercised on a cycle ergometer 3 days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO2peak). Data were analysed with General Linear Mixed Models and Cohen’s d effect sizes were calculated.Results
All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7 ± 13.2% vs 79.4 ± 12.0%; p = 0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO2peak by 19.3% (d = 1.28) and MOD had a non-significant 5.6% (d = 0.72) increase, compared to CON which had a 2.6% decrease.Conclusions
This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials. 相似文献103.
104.
Children with a specific learning disorder (SLD) are often characterized by marked intellectual strengths and weaknesses. In the last few years, research has focused on a common discrepancy between low working memory and processing speed on the one hand, and high verbal and visuoperceptual intelligence on the other. SLD profiles featuring a specific discrepancy between verbal and visuoperceptual abilities have been only marginally considered, however, and their systematic comparison vis-à-vis typically-developing (TD) populations has yet to be conducted. The present study examined a dataset of 1624 WISC-IV profiles of children with a diagnosis of SLD. It emerged that the proportion of children with a Verbal Comprehension Index (VCI) at least 1.5 SD (22 standardized points) lower than their scores on the Perceptual Reasoning Index (PRI) was larger than the proportion of SLD children with the opposite discrepant profile; it was also larger than the same proportion found among TD children. Comparing the two discrepant profiles revealed that the children also differed by type of learning difficulty, gender, and performance in the WISC-IV Symbol search task. Further examination suggested that children who were discrepant and also distinctly poor in visuoperceptual intelligence were particularly slow in general processing. 相似文献
105.
目的 采用网络药理学阐明济脉通片多成分-多靶点-多途径的作用理念,为进一步研究济脉通片降压药效物质基础和机制提供一定理论参考。方法 通过TCMSP数据库,结合口服利用度(≥ 30%)和类药性分析(≥ 0.18)参数,筛选济脉通片的活性成分;通过Drugbank和TCMSP数据库进行靶点预测分析;通过GENCARD数据库筛选出高血压疾病相关基因;结合DAVID和KEGG数据库进行GO分析和通路分析;使用Cystoscope软件构建"化合物-靶点-作用通路"网络图。结果 经筛选后得到济脉通片的33个化合物,148个潜在靶基因并映射到了223条信号通路,其中31条信号通路与高血压的发生发展密切相关,其中AGE-RAGE signaling pathway in diabetic complications、PI3K-Akt signaling pathway、TNFsignaling pathway、Adrenergic signaling in cardiomyocytes和Focal adhesion为重要的通路枢纽。结论 济脉通片主要通过多成分、多靶点、多通路调节血管内皮功能、炎症反应、钙钠离子转运、糖脂代谢等参与血管舒张、改善炎症、调节机体代谢、调节离子转运等而产生降压作用。 相似文献
106.
107.
《结合医学学报(英文版)》2019,17(4):250-260
BackgroundAutism spectrum disorder is a condition that affects all races, ethnic and socioeconomic groups. With a high incidence ratio of one in every 68, it has become one of the most discussed psychiatric disorders. For this reason, the need for investigating novel treatments has been emerging. Qigong, a traditional Chinese mind-body technique, has already proven to be able to reduce symptoms of several physical and psychological illnesses.ObjectiveThe purpose of this systematic review is to examine and categorize the current scientific evidence regarding the efficacy of Qigong on children suffering from autism spectrum disorders.Search strategyA systematic literature search of the electronic scientific databases PubMed, Clinical Trials.gov, BioMed Central, PubMed Central and Google Scholar was performed to identify studies of Qigong in the treatment of children with autism spectrum disorder.Inclusion criteriaThis review included randomized controlled trials, replication studies, retrospective studies and observational follow-up studies of Qigong on children with autism spectrum disorder. Case reports and case series were excluded.Data extraction and analysisTwo researchers independently evaluated the methodological quality of all included studies. Any discrepancies were solved by discussion until consensus was achieved.ResultsOur literature search identified 157 publications, and 10 additional publications from hand search of references. After duplicate removal, 103 records remained. After the title/abstract screening, 19 publications were obtained for detailed evaluation. After detailed evaluation, 10 studies were included. Seven studies were conducted with small children with 2–6 years old employing Qigong massage, and three studies were conducted with older children aged 7–17 years old applying both Qigong massage (one study) and Neigong (two studies).ConclusionStudies demonstrated that Qigong has interesting and promising applicability and effect on children with autism spectrum disorder and should be tested further. Despite the need for more rigorous controlled studies, Qigong seems to be able to decrease severity of individual sensory, behavioural, and language components of autism, and improve self-control, sociability, sensory and cognitive awareness as well as healthy-physical behaviour. Besides positive effect on children and adolescents, benefits seem to extend to parents and caregivers as well. However, quality of methodology seems to be insufficient to state that Qigong is an alternative to common behavioural therapies. We suggest that, until more investigation is performed, Qigong may only be used as a complement, or when behavioural therapies are not accessible. 相似文献
108.
109.
《L'Encéphale》2022,48(2):188-195
Depressive disorder is characterized by a polymorphic symptomatology associating emotional, cognitive and behavioral disturbances. One of the most specific symptoms is negative beliefs, called congruent to mood. Despite the importance of these beliefs in the development, the maintenance, and the recurrence of depressive episodes, little is known about the processes underlying the generation of depressive beliefs. In this paper, we detail the link between belief updating mechanisms and the genesis of depressive beliefs. We show how depression alters information processing, generating cognitive immunization when processing positive information, affective updating bias related to the valence of belief and prediction error, and difficultie to disengage from negative information. We suggest that disruption of belief-updating mechanisms forms the basis of belief-mood congruence in depression. 相似文献
110.
目的 探索珠海地区NRXN1和NLGN1基因多态性与儿童孤独症易感性的关系,为孤独症的防治提供科学依据。方法 采用病例对照的研究方法,选取2011-2016年就诊于珠海市妇幼保健院的123例珠海地区的孤独症患儿和506例健康对照。采用口腔拭子采集口腔上皮细胞以提取DNA,采用Sequenom Mass Array platform分型技术对NRXN1基因上的rs1045881和rs11885824以及NLGN1上的rs9855544进行基因分型。结果 NRXN1基因上的rs1045881和rs11885824以及NLGN1上的rs9855544位点基因型分布在孤独症组和健康对照组比较,差异无统计学意义;但NLGN1基因上的rs9855544与NRXN1基因上的rs11885824存在基因与基因间的交互作用(预测准确率为0.480,交叉验证一致性为10/10,P=0.040)。结论 NRXN1基因上的rs1045881和rs11885824以及NLGN1上的rs9855544位点基因多态性可能与孤独症易感性没有关联,但NLGN1基因上的rs9855544与NRXN1基因上的rs11885824之间的交互作用可能是孤独症易感性的影响因素。 相似文献