全文获取类型
收费全文 | 42209篇 |
免费 | 5788篇 |
国内免费 | 1045篇 |
专业分类
耳鼻咽喉 | 166篇 |
儿科学 | 525篇 |
妇产科学 | 432篇 |
基础医学 | 2147篇 |
口腔科学 | 1583篇 |
临床医学 | 7854篇 |
内科学 | 2712篇 |
皮肤病学 | 177篇 |
神经病学 | 1618篇 |
特种医学 | 762篇 |
外国民族医学 | 1篇 |
外科学 | 4571篇 |
综合类 | 5619篇 |
现状与发展 | 1篇 |
一般理论 | 25篇 |
预防医学 | 8145篇 |
眼科学 | 254篇 |
药学 | 5976篇 |
83篇 | |
中国医学 | 5330篇 |
肿瘤学 | 1061篇 |
出版年
2024年 | 165篇 |
2023年 | 1173篇 |
2022年 | 1382篇 |
2021年 | 2407篇 |
2020年 | 2530篇 |
2019年 | 2289篇 |
2018年 | 2137篇 |
2017年 | 2234篇 |
2016年 | 2078篇 |
2015年 | 2002篇 |
2014年 | 3084篇 |
2013年 | 4193篇 |
2012年 | 2724篇 |
2011年 | 2905篇 |
2010年 | 2171篇 |
2009年 | 2009篇 |
2008年 | 2145篇 |
2007年 | 1975篇 |
2006年 | 1745篇 |
2005年 | 1324篇 |
2004年 | 1034篇 |
2003年 | 957篇 |
2002年 | 723篇 |
2001年 | 627篇 |
2000年 | 580篇 |
1999年 | 391篇 |
1998年 | 334篇 |
1997年 | 304篇 |
1996年 | 255篇 |
1995年 | 172篇 |
1994年 | 151篇 |
1993年 | 143篇 |
1992年 | 110篇 |
1991年 | 79篇 |
1990年 | 89篇 |
1989年 | 61篇 |
1988年 | 64篇 |
1987年 | 50篇 |
1986年 | 40篇 |
1985年 | 41篇 |
1984年 | 27篇 |
1983年 | 18篇 |
1982年 | 18篇 |
1981年 | 19篇 |
1980年 | 25篇 |
1979年 | 10篇 |
1978年 | 8篇 |
1977年 | 10篇 |
1976年 | 7篇 |
1974年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 128 毫秒
91.
92.
《Value in health》2020,23(10):1340-1348
ObjectivesWe applied principles for conducting economic evaluations of factorial trials to a trial-based economic evaluation of a cluster-randomized 2 × 2 × 2 factorial trial. We assessed the cost-effectiveness of atorvastatin, omega-3 fish oil, and an action-planning leaflet, alone and in combination, from a UK National Health Service perspective.MethodsThe Atorvastatin in Factorial With Omega EE90 Risk Reduction in Diabetes (AFORRD) Trial randomized 800 patients with type 2 diabetes to atorvastatin, omega-3, or their respective placebos and randomized general practices to receive a leaflet-based action-planning intervention designed to improve compliance or standard care. The trial was conducted at 59 UK general practices. Sixteen-week outcomes for each trial participant were extrapolated for 70 years using the United Kingdom Prospective Diabetes Study Outcomes Model v2.01. We analyzed the trial as a 2 × 2 factorial trial (ignoring interactions between action-planning leaflet and medication), as a 2 × 2 × 2 factorial trial (considering all interactions), and ignoring all interactions.ResultsWe observed several qualitative interactions for costs and quality-adjusted life-years (QALYs) that changed treatment rankings. However, different approaches to analyzing the factorial design did not change the conclusions. There was a ≥99% chance that atorvastatin is cost-effective and omega-3 is not, at a £20 000/QALY threshold.ConclusionsAtorvastatin monotherapy was the most cost-effective combination of the 3 trial interventions at a £20 000/QALY threshold. Omega-3 fish oil was not cost-effective, while there was insufficient evidence to draw firm conclusions about action planning. Recently-developed methods for analyzing factorial trials and combining parameter and sampling uncertainty were extended to estimate cost-effectiveness acceptability curves within a 2x2x2 factorial design with model-based extrapolation. 相似文献
93.
Stephen Hanessian 《ACS medicinal chemistry letters》2016,7(1):6-9
Current major advances in drug discovery
can be traced back to
pioneering contributions originating from academics over a century
ago. Living in a symbiotic yet noninvasive coexistence, the academic
community and the pharmaceutical industry have strived, each in their
own way, to develop the modern medicines that benefit humankind today.
The subject is presented from a historical and personal perspective. 相似文献
94.
Sibusiso Mdletshe Marcus Oliveira Bhekisipho Twala 《Journal of Medical Imaging and Radiation Sciences》2021,52(2):172-178
Recently, there has been a call for research-informed and research-developed practice in health sciences education. This prompts the consideration of alternative suitable research approaches that could be used to enhance health sciences education practice, including medical radiation sciences education (MRSE) practice. In this discussion paper, the authors uphold design science research (DSR) methodology as a suitable research approach to enhance MRSE practice and research. An overview of the DSR methodology and an example of a project that used DSR methodology are presented to demonstrate the application of this methodology in MRSE practice and research. The paper concludes that the use of DSR methodology could be instrumental in addressing practice related challenges while developing a theoretical contribution to the discipline. 相似文献
95.
96.
河南省疟疾防治研究回顾 总被引:1,自引:0,他引:1
本文从病原学、流行病学、诊断学、传播媒介和现场控制等方面回顾了河南省疟疾防治研究所取得的成果,并根据疟疾流行的现状,提出了将来的研究方向。 相似文献
97.
98.
James H. McKerrow 《Perspectives in Drug Discovery and Design》1995,2(3):437-444
Summary Papain family cysteine proteases function primarily intracellularly in higher eukaryotes, but are often extracellular proteases in protozoan helminths. The utility of this class of enzymes is reflected in the diversity of functions they perform in both parasite life cycles and the pathogenesis of parasitic diseases. Examples include secretion of proteases into the gut of parasitic worms for hemoglobin degradation, release from the surface of nematodes to degrade cuticular proteins during molting, and facilitating excystment of protozoa. 相似文献
99.
J.I. Smedberg E. Lothigius I. Bodin A. Frykholm K. Nilner 《Clinical oral implants research》1993,4(1):39-46
In order to satisfy the need to restore the aesthetics, phonetics and comfort and to facilitate optimal hygiene procedures, 20 edentulous patients were treated with a new concept of overdenture therapy on implants ad modum Brånemark. After 24±3.5 months the patients were re‐examined. They were asked to answer a questionnaire and use a Visual Analogue Scale (VAS) to give their opinion on the prosthetic treatment. The results indicate that an implant‐retained overdenture in the maxilla with this design can satisfy the patients needs in aesthetics, phonetics and comfort and can 1 facilitate oral hygiene measures. 相似文献
100.
实验表明,脾肾两虚、气血不足患者唾液蛋白明显下降,与正常人相比差异明显(P<0.01);脾肾两虚患者唾液蛋白与血浆白蛋白及总蛋白量成正相关性,气血不足患者唾液蛋白与血色素、红细胞量亦成正相关性。 相似文献