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61.
Eric T. Stoopler DMD res Pinto DMD Faizan Alawi DDS Sree Raghavendra DMD Ricardo Boyce Jr. DDS David Porter MD Thomas P. Sollecito DMD 《Special care in dentistry》2004,24(2):65-69
Acute myelogenous leukemia (AMU is a hematologic disorder that is characterized by an abnormal proliferation of immature myeloid cells. Granulocytic sarcomas are clusters of leukemic myeloid cells that may develop as a result of AML. Oral manifestations of AML are common and often involve enlargements of the gingiva and/or mucosal tissue from direct leukemia cell infiltration. We describe the case history of a 50-year-old man who had an ulcera-tive lesion of the oral mucosa that was determined to be a granulocytic sarcoma of AML-M0 subtype. The combination of both the subtype and clinical presentation of the leukemia makes this presentation unusual, and to the best of our knowledge, of a type that has not been previously reported in the literature. 相似文献
62.
Moussa Ndong Machiko Kazami Tsukasa Suzuki Mariko Uehara Shin-ichi Katsumata Hirohumi Inoue Ken-Ichi Kobayashi Tadahiro Tadokoro Kazuharu Suzuki Yuji Yamamoto 《Nutrition Research》2009,29(9):640-647
Iron deficiency (ID) is one of the most commonly known forms of nutritional deficiencies. Low body iron is thought to induce neurologic defects but may also play a protective role against cancer development by cell growth arrest. Thus, ID may affect cellular pathways controlling cell growth and proliferation, the mechanism of which is still not fully understood. The serine/threonine protein kinase Akt and its downstream target, the mammalian Target of Rapamycin (mTOR), is known to play a crucial role in the regulation of cell growth and survival. Therefore, we hypothesized that Akt/mTOR pathway could be influenced by ID. Three-week-old male Wistar-strain rats were divided into 3 groups and the 2 groups had free access to a control diet (C group) or an iron-deficient diet (D group). The third group (PF group) were pair-fed the control diet to the mean intake of the D group. After 4 weeks, rats were killed and their brains were sampled. In separate experiments, COS-1 cells were cultured with or without the iron chelator deferoxamine. Western blots of brain samples and COS-1 lysates were used to analyze the expression and phosphorylation state of Akt, TSC2, mTOR, and S6 kinase proteins implicated in the Akt/mTOR pathway. Using 2 different ID models, we show for the first time that iron deficiency depresses Akt activity in rats and in COS-1 cells, leading to a decrease in mTOR activity. 相似文献
63.
邻近皮瓣修复面部皮肤缺损 总被引:1,自引:0,他引:1
目的 探讨邻近皮瓣修复面部皮肤缺损的应用效果。方法 162例面部病变切除后皮肤缺损患者,其中先天性色素痣63例,基底细胞癌28例,鳞状细胞癌6例,其他皮肤病变65例。均采用邻近皮瓣即时修复,其中菱形皮瓣57例、双叶皮瓣8例,A-T皮瓣23例、V-Y皮瓣13例、Z成形术23例、推进皮瓣27例、鼻状皮瓣11例。结果 162例皮瓣存活良好,手术切口1期愈合,存活后皮瓣颜色与邻近部位无明显差异,术后无眼睑、眉毛、鼻梁及口角牵扯歪钭,术后3个月切口不显露。结论 邻近皮瓣是修复面部较大皮肤缺损的良好方法,手术外观效果好。 相似文献
64.
目的探讨冬凌草甲素对B淋巴细胞白血病细胞株Raji细胞的增殖抑制作用及其机制。方法以不同浓度的冬凌草甲素作用于体外培养的Raji细胞,MTT法检测细胞生长抑制率,应用流式细胞仪、Hoechst 33258荧光染色法观察细胞凋亡,TRAP-PCR-ELISA法检测细胞凋亡前后的端粒酶活性。结果冬凌草甲素可显著降低Raji细胞的端粒酶活性,抑制细胞的生长,诱导细胞发生凋亡,并呈现出明显的剂量-效应与时间-效应关系。结论冬凌草甲素对B淋巴细胞白血病具有明显的体外抗白血病作用,降低细胞端粒酶活性,诱导细胞发生凋亡,可能是其重要作用机制。 相似文献
65.
Cytosine deaminases (CDs) in bacteria andfungi are found to deaminate prodrug 5 - FC intocytotoxic agent 5 - FU .Yeast CD (YCD) is clonedfrom Saccharomyces cerevisiae.It has been shownpreviously that YCD was more efficient inconversing5 - FC than bacterial CD(b CD) [1-3 ] .As anovel suicide gene therapy system,YCD/ 5 - Fcsystem may be promising in cancer therapy andprevention of graft versus host disease.In thepresent study,we established a P388/ DBA murineleukemia model by infusin… 相似文献
66.
67.
云南省600例0~5岁儿童维生素A缺乏调查 总被引:3,自引:3,他引:0
目的:了解云南省城乡0~5岁儿童维生素A营养状况及影响因素。方法:省、地、县随机整群抽取600例儿童,采用微量荧光光度法检测VitA含量。结果:VitA缺乏发生率16·17%,地、县明显高于省会城市;0岁儿童明显高于其他年龄组;腹泻儿童明显高于正常儿童;VitA缺乏的影响因素:近1周内进食鸡蛋、奶类制品、鱼虾类、肝类、黄绿色蔬菜、鱼肝油等食物有利于维生素A的吸收,急性呼吸道感染、发烧与维生素A缺乏发生率差异不明显。结论:维生素A缺乏发生率城市明显低于农村地、县两级,说明维生素A缺乏防治工作重点在农村,特别是0岁儿童,防治的主要措施是采取合理膳食,均衡营养,控制腹泻流行。 相似文献
68.
M L Cibull M E Thompson L Smith C D Jennings M A Doukas E J Pavlik D E Powell 《American journal of hematology》1987,24(3):293-299
The emergence of a near-haploid clone of cells in blast phase chronic myelogenous leukemia is an unusual event. We report such a case and review eight other cases described in the English literature. The significance of the substantial loss of genetic material is discussed as is the phenotypic and genotypic heterogeneity observed in this group of patients. 相似文献
69.
通过半年对35名7~12岁轻度碘缺乏病儿童进行补碘,并与同龄、同地的正常儿童和缺碘未补碘儿童进行比较,以观察补碘对儿童脑功能及生长发育的影响。结果发现:①补碘可使儿童碘营养状况恢复正常,尿碘值由(83.2±3.5)μg/L上升到(162.2±1.6)μg/L,血清T4、FT4I和rT3:也与正常儿童一致而与未补碘儿童有显著性差异(P<0.05).②轻度碘缺乏病儿童智商低于正常儿童(P<0.01),补碘在一定程度上改善其智商水平。③轻度碘缺乏病及补碘未能明显影响儿童的生长发育,可能与儿童总营养水平较差有关。 相似文献
70.
Diminished effect of etidronate in vitamin D deficient osteopenic postmenopausal women 总被引:7,自引:0,他引:7
J. C. Koster W. H. L. Hackeng H. Mulder 《European journal of clinical pharmacology》1996,51(2):145-147
Objective: The effects of vitamin D deficiency in osteopenic postmenopausal women treated with intermittent cyclical etidronate have
been studied. Bone mass and biochemical parameters as bone markers were measured before and after one year of therapy with
intermittent cyclical etidronate.
Results:
In 30 patients without vitamin D deficiency, bone mass in the lumbal spine and femoral neck was significantly increased compared
to 28 vitamin D deficient patients. After cyclical intermittent etidronate therapy, serum osteocalcin and PTH were significantly
increased in the vitamin D deficient patients, whereas in non-vitamin D deficient patients they did not change.
Conclusion:
It is worthwhile measuring serum vitamin D before starting etidronate therapy and, in case of deficiency, to give vitamin
D.
Received: 6 April 1995/Accepted in revised form: 23 April 1996 相似文献