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941.
ABSTRACT. Sixty of 68 consecutive patients detected during the first two years of the Swedish screening programme for congenital hypothyroidism were Griffiths tested at the age 6.5–7.5 years. The test quotients of the patients could not be distinguished from those of reference population. Replacement therapy with 8.7 ± 2.8 μg of l -thyroxine (mean±SD)/kg/d had been started at 15.0 ± 7.1 days of life. Furthermore, normal results on Griffiths tests were also found in 13 patients with delayed normalization of serum TSH, i.e. ≥ 19 mU/l at the age of six weeks, as well as in patients with retarded skeletal maturity and/or very low neonatal serum levels of thyroxine, i.e. < 18 nmol/l and tri-iodothyronine, i.e. <0.92 nmol/l. Our findings indicate that replacement dose of 6–11 μg l -thyroxine/kg/d is adequate and allows normal psychological development if treatment is started early. 相似文献
942.
R. B. Deshpande Nalini N. Hasgekar A. R. Chitale V. S. Lalitha 《Fetal and pediatric pathology》1989,9(2):141-151
The morphological features of kidney neoplasms induced by ethylnitrosourea (ENU) with or without prior irradiation were examined with a view to comparing them with human renal tumors of childhood. The rat renal tumors consisted of poorly differentiated, highly mitotic mesenchymal cells frequently attempting to differentiate along fibroblastic and myofibroblastic lineages. Though the host renal tubules were frequently entrapped in these tumors, immature tubules and islands of epithelial cells occasionally were seen to form an integral part of the neoplasms. Rarely, adenomatous areas surrounded by mesenchymal proliferation were observed. None of the tumors had the blastemal component that is the hallmark of nephroblastoma. The rat mesenchymal tumors resembled the human congenital mesoblastic nephroma. 相似文献
943.
A. LEONHARDT P. G. KÜHL H. SCHWEER D. WOLF H. W. SEYBERTH 《Acta paediatrica (Oslo, Norway : 1992)》1989,78(6):853-857
ABSTRACT. In general, prostanoids act as local mediators, not as circulating hormones. A specific exception to this rule is the infusion of prostaglandin E1 in patients with ductus arteriosus-depend-ent pulmonary or systemic blood flow associated with congenital heart disease. We therefore measured prostaglandin E, plasma levels by gas chromatography-mass spectrometry during effective infusion of prostaglandin E1 in 10 neonates. Prostaglandin E1 plasma levels ranged from 22 to 530 (median 56) pg/ml in these patients. Since prostaglandin E1 is not synthesized endogenously to any significant extent, these plasma concentrations constitute genuine circulating levels not confounded by the common problem of e vivo artifacts. If endogenous prostanoids (e.g. prostaglandin E2 ) are suspected as circulating mediators, plasma levels detected by reliable methods ought to be in the same range as prostaglandin E1 plasma levels in the present investigation. 相似文献
944.
ELHAM HAMMAD INGEMAR HELIN ALEXANDER PACSA 《Acta paediatrica (Oslo, Norway : 1992)》1989,78(6):963-964
ABSTRACT. A case of congenital anomalies following varicella infection in the 8th week of gestation is described. Though the baby demonstrated a majority of the features characteristic of the congenital varicella syndrome and had positive immunofluorescent and ELISA tests for VZ specific antibodies, no vesicles or depigmented skin areas were seen. 相似文献
945.
D. F. Schorderet S. Dahoun I. Defrance D. Nusslé M. A. Morris 《European journal of pediatrics》1992,151(8):586-589
A Kurdish family had two children affected with Robinow syndrome. The daughter had short stature, macrocephaly, hypertelorism, hepatosplenomegaly, short forearms and marked vertebral anomalies. Her brother had hypertelorism, hypertrophied alveolar ridges, hepatosplenomegaly, short forearms, rib anomaly and ambiguous genitalia. The karyotype of the affected male sibling showed mosaicism for 45X, 46,X,dicY(q11.22), 47,X,dicY(q11.22),dicY(q11.22). 相似文献
946.
L Van Maldergem Y Gillerot E Vamos M Toppet P Watillon G Van Vliet 《Acta paediatrica (Oslo, Norway : 1992)》1992,81(4):365-367
A boy presented with ectrodactyly (lobster claw deformity), bilateral cleft lip and palate, semilobar holoprosencephaly and microcephaly, associated with congenital hypogonadotropic hypogonadism and central diabetes insipidus. Other aspects of pituitary function were normal. We suggest that the ectrodactyly-ectodermal dysplasia-clefting syndrome can be associated with a variety of hypothalamo-pituitary dysfunctions, in addition to the already described isolated growth hormone deficiency. 相似文献
947.
采用NADPH二磷酸酶组织化学方法,研究先天性巨结肠症NANC抑制性神经系统。结果提示狭窄段肠管缺乏NOS阳性神经丛,肌层内有散在神经纤维,有时可见到粗纤维或小神经干;正常结肠和巨结肠正常段富含阳性神经节细胞和神经纤维。提示NO与先天性巨结肠发病机理有关。 相似文献
948.
64例先天性胆总管囊肿术后随访及中药治疗 总被引:2,自引:0,他引:2
1979~1992年共手术治疗先天性胆总管囊肿并随访64例,男19例,女45例,年龄5天~12岁,随访时间10个月~14年,平均4年3个月。未发现癌变患儿。经临床体检、血肝功能测定、血透明质酸测定、B超及GI检查,碱性磷酸酶增高60例,透明质酸增高6例,钡剂返流7例,胆道积气2l例,胆道蛔虫4例,胆道结石5例。发现囊肿切除肝管空肠Roux-Y吻合加矩形瓣手术可预防返流的发生,且其术后并发症最少。根据患儿随访情况,采用中药“胆康1号”治疗各种并发症,总有效率达95%。 相似文献
949.
Elly M. -J. Xenakis MD Oded Langer MD Jeanna M. Piper MD Deborah Conway MD Michael D. Berkus MD 《American journal of obstetrics and gynecology》1995,173(6):1874-1878
OBJECTIVE: Our purpose was to compare the efficacy and safety of low-dose versus high-dose oxytocin regimens in the augmentation of labor.STUDY DESIGN: Three hundred ten term pregnancies requiring augmentation of labor underwent randomization to receive either a low-dose or high-dose oxytocin augmentation regimen. Maternal demographics, labor-delivery data, and neonatal outcome were compared.RESULTS: The hgih-dose oxytocin group had a significant lower cesarean section rate, regarless of parity (10.4% vs 25.7%. p < 0.001), with no differences in maternal complications and neonatal outcomes. The time needed to correct the labor abnormality as also significantly decreased (1.24 ± 1.4 hours vs 3.12 ± 1.6 hours, p < 0.001) in the high-dose group.CONCLUSIONS: The use of a high-dose oxytocin regimen benefits both nulliparous and multiparous women requiring labor augmentation by significantly lowering both the time necessary to correct the labor normality and the need for cesarean section. 相似文献
950.
Andrew C. Swift S.Dev. Singh 《International journal of pediatric otorhinolaryngology》1985,10(3):253-261
Nasal gliomata are rare and experience in management is therefore not widespread. Clinical details of 5 children with nasal gliomata are presented. In each case the glioma was excised by an external approach without the need for craniotomy. These cases demonstrate the variability of presenting features and problems in management. They illustrate a relatively conservative surgical approach to treatment which we consider to be safe and effective. The characteristics of these unusual neural malformations are reviewed, and the management is discussed. 相似文献