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991.
情绪唤醒度对女性持续性疼痛调制的行为学研究 总被引:1,自引:1,他引:0
目的 研究情绪唤醒度对女性持续性疼痛的镇痛效应.方法 采用15名女性被试,先对情感图片进行分类,分为愉快、中性、不愉快3组,观看不同类别图片的同时给予冷痛或热痛刺激,记录在不同类别图片刺激下,被试的疼痛耐受时间.结果 ①相对于中性图片,观看愉快图片和不愉快图片时,被试对热痛的耐受时间明显延长[不愉快组(146.20±13.68)s,中性组(86.73±12.93)s,愉快组(145.27±15.99)s,F(2.42)=5.718,P<0.01];②在冷痛试验中,各条件下被试的耐受时间差异无显著性[不愉快组(74.73±15.78)s,中性组(68.80±15.85)s,愉快组(78.80±14.81)s,F(2.42)=0.109,P>0.05];③愉快组和中性图片组唤醒度差与二者热痛耐受时间差之间存在显著线性关系(r=0.546,P=0.035).结论 ①唤醒度可能是女性持续性热痛调节的关键因素之一;②冷、热痛觉的调制可能存在不同的神经传导通路. 相似文献
992.
目的:探讨改良式冷刀锥切术在治疗高级别宫颈上皮内瘤样病变中的价值。方法:对我院2007年1月~2009年12月接受宫颈锥切术的172例高级别宫颈上皮内瘤样病变患者的临床资料进行回顾性分析。根据手术方式分为两组,改良式冷刀锥切术为改良组,传统冷刀锥切术为对照组。比较两组的手术时间、术中出血量、切缘病理情况、术后宫颈狭窄或粘连发生率及宫颈鳞柱交界可见率等。结果:改良组平均手术时间及术中平均出血量明显少于对照组(P<0.05)。改良组与对照组切缘阳性率(5.6%、6.7%)、宫颈狭窄或粘连发生率(0、4.8%)差异均无统计学意义(P<0.05),而鳞柱交界可见率(93.2%、77.1%)差异有统计学意义(P<0.05)。结论:改良式冷刀锥切术,可以提供良好的锥切标本,并有效减少术中出血,缩短手术时间,同时具有术后宫颈鳞柱交界可见率高,有利于术后随访等优点,值得临床推广。 相似文献
993.
Daly PJ Docherty NG Healy DA McGuire BB Fitzpatrick JM Watson RW 《BJU international》2009,103(2):254-259
OBJECTIVE
To examine whether hypoxia (one of the many components of ischaemic preconditioning) can induce a protective response in culture renal tubular cells, and thus determine if non‐lethal periods of hypoxia could confer protection against apoptotic injury to human proximal tubular cells during cold storage and subsequent cytotoxic insult, and establish the cellular mechanisms by which this protection is induced.MATERIALS AND METHODS
Human proximal tubular cells (HK‐2) were pre‐incubated for 24 h in normoxic or hypoxic conditions and then incubated at 4 °C for 6 h to mimic cold storage, before being returned to normal conditions and exposed to varying concentrations of cyclosporine A (CSA). Cell viability and apoptosis were measured using propidium iodide staining and flow cytometry. The expression of heat‐shock protein (HSP)‐70 was determined by Western blotting.RESULTS
Hypoxia had no effect on cell viability or apoptosis. Pre‐exposure of cells to hypoxia significantly protected against CSA‐induced damage even after a period of cold storage. Western blotting analysis showed that hypoxia up‐regulated the anti‐apoptotic protein HSP‐70. HK‐2 cells over‐expressing HSP‐70 mimicked hypoxia preconditioning, in that they were protected during cold storage and CSA‐induced apoptosis.CONCLUSION
Exposure of renal tubular cells to a sequential model of cold storage, reperfusion and incubation with CSA resulted in apoptotic cell death. Preconditioning these cells with hypoxia induced a protective response and up‐regulation of the anti‐apoptotic protein HSP‐70. There was a similar response in non‐preconditioned cells over‐expressing HSP‐70. Further understanding of the cellular changes occurring during this period of preconditioning will allow the development of more targeted, clinically relevant methods of preconditioning in renal transplantation. 相似文献994.
目的:评价布洛伪麻那敏片治疗由普通感冒或感冒所致的上呼吸道症状的有效性和安全性。方法:采用多中心、随机双盲、阳性药物平行对照研究。共完成的病例数为226例。其中A组112例,B组114例,分别予以布洛伪麻那敏片和氨酚伪麻那敏片治疗,药物用法为每日3次,每次1片,疗程3~5d。结果:A组的总有效率为100.00%,总显效率为98.21%;B组的总有效率为99.12%,总显效率为97.37%。表明A组和B组总疗效差异无统计学意义(P〉0.05)。两组总有效率和总显效率非劣效性检验显示,A组非劣效于B组(P〈0.05)。不良反应发生率,A组和B组分别为20.18%和24.79%(P〉0.05)。结论:布洛伪麻那敏片和氨酚伪麻那敏片均系对症治疗感冒所致上呼吸道症状的安全有效药物。 相似文献
995.
996.
王玉玺老师治疗小儿感冒临床经验 总被引:1,自引:0,他引:1
王玉玺老师临证时注重辨别小儿感冒的寒热虚实、轻中重度,用药也简练、轻清,在预防方面除了药物预防外,还强调饮食和起居。 相似文献
997.
Cold agglutinin induced autoimmune hemolytic anemia is uncommonly associated with leukemia and lymphomas. We present a case of a young Mexican female presenting with a cold agglutinin hemolytic anemia with expression of a rare Pr antigen specificity and an aggressive NK-cell leukemia. Our patient had a rapid fatal course. To our knowledge this is the first reported case of such an association. 相似文献
998.
Sylvester KP Patey RA Rafferty GF Rees D Thein SL Greenough A 《Pediatric pulmonology》2007,42(3):272-276
To determine the occurrence and magnitude of airway hyperresponsiveness (AHR) in children with sickle cell anemia (SCA) who had or had not had acute chest syndrome (ACS) episodes. A subsidiary aim was to determine whether cold air and exercise challenge testing gave similar results in children with SCA. AHR would be greater in SCA children who had had an ACS episode compared to those who had not. Prospective observational study. Forty-two SCA children (median age of 11.5 [range 6.1-16.8] years); 12 children had been previously hospitalized for an ACS episode. AHR was assessed by the change in forced expiratory volume in 1 sec (FEV1) to a cold air challenge and in a subset of the children to an exercise challenge. A positive result to either challenge was deemed to have occurred if the FEV1 fell by at least 10% from the pre-challenge baseline. The magnitude of change in FEV1 following the cold air challenge was similar in children who had or had not had an ACS episode. Six children had a positive response to the cold air challenge (AHR); none had had an ACS hospitalization. Similar proportions of children responded to the cold air and exercise challenge and the magnitude of response to the two tests was similar. Some children, however, responded only to a cold air challenge and others only to an exercise challenge. SCA children who had had an ACS hospitalization episode compared to those who had not were not more likely to respond to a cold air challenge. Importantly, if AHR is to be correctly diagnosed, some SCA children will require to undergo both cold air and exercise challenge testing. 相似文献
999.
Wiersma P Chappell MA Williams JB 《Proceedings of the National Academy of Sciences of the United States of America》2007,104(52):20866-20871
Compared with temperate birds, tropical birds have low reproductive rates, slow development as nestlings, and long lifespans. These “slow” life history traits are thought to be associated with reduced energy expenditure, or a slow “pace of life.” To test predictions from this hypothesis, we measured exercise-induced peak metabolic rates (PMRE) in 45 species of tropical lowland forest birds and compared these data with PMRE for three temperate species. We also compared cold-induced PMR (PMRC) with PMRE in the same individuals of 19 tropical species. Tropical birds had a 39% lower PMRE than did the temperate species. In tropical birds, PMRC and PMRE scaled similarly with body mass (Mb), but PMRE was 47% higher than PMRC. PMRE averaged 6.44 × basal metabolic rate (BMR) and PMRC averaged 4.52 × BMR. The slope of the equation relating PMRE to Mb exceeded the slope for the equation for BMR vs. Mb, whereas slopes for the equations of PMRC and BMR vs. Mb did not differ. Mb-adjusted residuals of PMRE were positively correlated with residual BMR, whereas residual PMRC and residual BMR were not correlated. PMRE and PMRC were not correlated after we corrected for Mb. Temperate birds maintained their body temperature at an 8.6°C lower average air temperature than did tropical species. The lower PMRE values in tropical species suggest that their suite of life history traits on the slow end of the life history continuum are associated with reduced metabolic rates. 相似文献
1000.
Pronociceptive changes in response properties of rostroventromedial medullary neurons in a rat model of peripheral neuropathy 总被引:1,自引:0,他引:1
The spared nerve injury (SNI) model of peripheral neuropathy produces a robust and long-lasting hypersensitivity. Previous behavioural studies suggest that brainstem-spinal pathways originating in or relaying through the rostroventromedial medulla (RVM) contribute to neuropathic hypersensitivity. We determined whether SNI induces changes in response properties of RVM neurons that might influence descending modulation of nociception. RVM neurons included in the study were classified into presumably pronociceptive ON-cells and antinociceptive OFF-cells (giving excitatory or inhibitory responses to noxious stimulation, respectively). Spontaneous activity and the response to cold, pinch and colorectal distension were assessed under light anaesthesia in the rat, 1 week and 8 weeks following nerve injury or sham operation. Spontaneous activity was increased 1 week but not 8 weeks after nerve injury in ON-cells but decreased in OFF-cells at both time points. In the SNI group, cold-evoked responses were enhanced particularly in ON-cells, independent of the postoperative time point. Responses of ON-cells to pinch and visceral stimulation were enhanced 8 weeks but not 1 week following nerve injury, whereas OFF-cell responses to pinch or colorectal distension were not changed. The results indicate that SNI induces pronociceptive changes in spontaneous activities of ON-cells and OFF-cells and peripherally evoked responses of ON-cells that vary with the postoperative time point. Increased ON-cell activity and decreased OFF-cell activity in the RVM are likely to enhance spinal nociception in a tonic fashion, whereas increased responses of ON-cells to peripheral stimulation are likely to enhance ascending nociceptive signals by a positive feedback following peripheral noxious stimulation. 相似文献