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991.
《Respiratory investigation》2022,60(2):227-233
BackgroundPatients with early-stage lung cancer who underwent R0 resection often encounter disease recurrence, especially during the early phase; thus, it is deemed vital to determine the predictive factors for recurrence after surgery. In this study, we aimed to identify the independent variables associated with recurrence after complete surgical resection of pathological stage I lung adenocarcinoma.MethodsWe retrospectively reviewed the medical records of 169 patients who underwent pulmonary resection for primary lung adenocarcinoma pathological stage I with curative intent lung cancer surgery from 2015 to December 2018 at our institution for information on the recurrence of the disease.ResultsPer the multivariate analysis, the presence of micropapillary pattern and vessel invasion were found to be independent predictors of disease recurrence after surgery (odds ratio [OR]: 9.36, 95% confidence interval [CI]: 2.42–36.2, P = 0.0012; and OR: 4.50, 95% CI: 1.52–13.4, P = 0.0068, respectively). Vessel invasion was also found to be an independent predictor of disease recurrence after surgery within a year (OR 11.4, 95% CI 3.08–42.5, P = 0.0003).ConclusionsThe presence of vessel invasion may help in distinguishing patients with the highest risk of early-phase disease recurrence after surgery. Patients with stage I adenocarcinoma with vessel invasion should undergo intensive surveillance after surgery. 相似文献
992.
目的探讨胃癌及癌前期病变粘膜芳香基酰胺酶(AAD)同工酶的表达规律,寻找癌前期病变及早期癌的标志物.方法采用本室建立的圆盘等电聚焦电泳(CIEF)分离122例各种胃病粘膜(胃癌41例,浅表性胃炎48例,萎缩性胃炎30例,胃溃疡8例,其中伴肠化19例,异型增生8例)中AAD同工酶.以60g/L丙烯酰胺作支持递质,pH35~50和pH35~100两种载体两性电解质建立pH梯度,加匀浆液50μl,阴极及阳极电极液分别用02mol/LNaOH和05mol/LH3PO4,恒压电泳(10℃)18h后以亮氨酰β萘胺作为基质呈色.结果AAD分为8条区带,从阳极到阴极依次命名为AADⅠ~AADⅧ,其中AADⅣ主要见于胃癌(902%),不完全大肠型肠化(867%)和异型增生(750%);而不伴有肠化或异型增生的良性胃病和正常胃中则未发现.AADⅣ的阳性率与胃癌病理类型、细胞分化程度及临床分期无相关,且AADⅣ等电点和胎盘型AAD等电点相当.结论AADⅣ是一种癌胚蛋白,即胃癌组织特异性同工酶,是癌前期病变及早期癌的标志物. 相似文献
993.
994.
Medich D McGinty J Parda D Karlovits S Davis C Caushaj P Lembersky B 《Diseases of the colon and rectum》2001,44(8):1123-1128
PURPOSE: Preoperative chemoradiotherapy followed by radical surgical resection has been the preferred treatment for patients presenting with locally advanced distal rectal carcinoma at our institutions. We postulated that chemoradiotherapy-induced pathologic response of the primary tumor would identify which patients would be candidates for local excision as definitive surgical therapy. METHODS: A retrospective analysis of 60 patients with palpable, locally advanced, distal rectal adenocarcinomas treated from 1995 to 2000 was performed. All patients received preoperative chemoradiotherapy consisting of 5-fluorouracil (325 mg/m2) and leucovorin (20 mg/m2) by bolus infusion on Days 1 through 5 and 29 through 33 delivered concurrently with at least 45.0 to 50.4 Gy of pelvic radiation, followed six to eight weeks later by radical surgery and then adjuvant chemotherapy. RESULTS: Among 60 patients (20 females) there was a mean age of 58.7 (28–84) years. Clinical staging was as follows: Stage II, 14 patients (23 percent); Stage III, 35 patients (58 percent); and Stage IV, 11 patients (18 percent). Pathologic examination revealed that negative margins were obtained in 58 patients (97 percent). Downstaging to T0-2N0 was achieved in 17 patients (28 percent), with five (8 percent) achieving a pathologically complete response. Lymph nodes were positive in 24 patients (40 percent) despite chemoradiotherapy. Pathologic node positivity was found in 0 of 5 pT0 patients, 9 (41 percent) of 22 pT1 or pT2, and 15 (45 percent) of 33 pT3. Clinical stage, tumor size, pathologic stage, and adverse histologic features could not reliably predict pN0 status, except pT0 (5 patients only). CONCLUSIONS: Preoperative chemoradiotherapy often downsizes and downstages locally advanced rectal carcinoma. Neither pretreatment clinical characteristics, response to preoperative chemoradiotherapy, or pathologic features reliably predict pN0 status. Therefore, local excision is not recommended as an alternative to radical surgery for locally advanced adenocarcinoma of the distal rectum regardless of the response of the primary tumor to preoperative chemoradiotherapy.Presented at the meeting of The American Society of Colon and Rectal Surgeons, Boston, Massachusetts, June 24 to 29, 2000. 相似文献
995.
JIANG Hai Xing LIU Zhi Ming ZHUANG Ya Qiang YANG Ding Hua JIANG Yi Qiang LI Jia Quan 《世界华人消化杂志》1998,(11)
INTRODUCTIONRecently,p16gene,aputativetumorsuppresorgene,hasbeenfounddeletedathighfrequencyinavarietyoftumorcellines[1,2],nev... 相似文献
996.
997.
观察表皮生长因子受体单克隆抗体对人肺癌细胞体外增殖的作用。探讨其在肺癌抗体生物治疗中的应用价值。方法 应用杂交瘤技术制备EGFR单在隆抗体并以噻唑蓝比色法检测EGFR单克隆抗体对人肺癌细胞体外增殖能力的影响。 相似文献
998.
Shibuya T Uchiyama K Kokuma M Shioya T Watanabe Y Moriyama Y Matsumoto K Yokosuka I 《Journal of gastroenterology》2002,37(5):387-390
Received: October 31, 2000 / Accepted: March 30, 2001 相似文献
999.
Yuko Omori Yusuke Ono Mishie Tanino Hidenori Karasaki Hiroshi Yamaguchi Toru Furukawa Katsuro Enomoto Jun Ueda Atsuko Sumi Jin Katayama Miho Muraki Kenzui Taniue Kuniyuki Takahashi Yoshiyasu Ambo Toshiya Shinohara Hiroshi Nishihara Junpei Sasajima Hiroyuki Maguchi Shinya Tanaka 《Gastroenterology》2019,156(3):647-661.e2
1000.