国家标准腧穴定位变化的分析与探讨

从解剖学知识、骨度折量定位法、指寸定位法和部分腧穴定位等角度分析了腧穴的最新标准化定位与常用腧穴学类教材/专著/标准的不同点,认为更多人体解剖学知识的引入可以使腧穴定位更为严谨,骨度分寸和部分腧穴定位的变化有待进一步探讨,而手指同身寸法的弱化可被视作弃用该法的铺垫。     

显微外科在骨科的临床应用(附512例报告)

目的：总结显微外科在骨科临床的治疗经验。方法：应用显微外科技术对断指（ 肢） 、骨缺损、复合组织缺损、血管神经离断缺损修复等七类５１２ 例进行临床处理。结果：５０１ 例获得成功,成功率９７ ．８ ％ 。结论：显微外科在骨科临床应用效果满意。     

肢体功能训练在累及肩肘腕指关节烧伤康复中的应用

目的：探讨肢体功能训练在累及肩、肘、腕、指关节烧伤的康复疗效。方法：对累积肩、肘、腕、指关节烧伤患者,随机分为康复组（肢体功能训练）和对照组（未进行功能训练）,进行疗效比较。结果：肢体功能训练组疗效明显高于对照组。结论：早期功能训练有利烧伤康复,临床应广泛应用。     

断指再植和拇指再造术后的计划性康复

目的 :探索断指再植和拇指再造术后康复方法和效果。方法 :设计断指再植和拇指再造术后计划性康复程序 ,应用BTEPrimus康复评估仪进行断指再植和拇指再造术后计划性、系统性康复 2 1例 ,并与 2 0例未系统康复的患者进行比较。结果 :计划康复组手指活动度恢复至健侧的 77%± 9% ,两指捏力恢复至健侧的 81%± 12 % ,三指捏力恢复至健侧的 83 %± 7% ,3个月后全部返回原工作岗位。计划康复组手功能的恢复明显优于对照组。结论 :断指再植和拇指再造术后计划性康复能有效地提高再植术后的手功能。     

323例末节断指再植的临床经验

目的 总结末节断指再植的临床经验。方法 采用静脉动脉化、血管移植、扩大近端骨髓腔的经骨髓腔静脉回流等方法治疗末节断指。结果 再植323例,其中成活314例,成活率97．1％。术后随访3个月～5年,根据中华医学会手外科学会断指再植功能评定试用标准,优217例,良89例,差8例。结论 采用静脉动脉化、血管移植、扩大近端骨髓腔的经骨髓腔静脉回流等再植方法不仅可以扩大再植适应证,提高断指再植成活率,而且有良好的外形及功能。     

RNF43 overexpression attenuates the Wnt/β-catenin signalling pathway to suppress tumour progression in cholangiocarcinoma

RING finger protein 43 (RNF43) is a ubiquitin E3 ligase that negatively regulates Wnt/β-catenin signalling. Mutation, inactivation and downregulation of RNF43 in cholangiocarcinoma (CCA) are associated with a less favourable prognosis. Since the functional role of RNF43 in CCA has not yet been demonstrated, the present study aimed to assess the effect of its overexpression in mediating CCA suppression via Wnt/β-catenin signalling pathway inhibition. Accordingly, RNF43 was overexpressed, and various malignant phenotypic changes studied, including cell proliferation, cell migration, chemotherapeutic sensitivity and the expression of several Wnt/β-catenin target genes. Overexpression of RNF43 in the CCA cell-line KKU-213B hindered activation of Wnt/β-catenin signalling, evidenced by: i) Accumulation of β-catenin in the cytoplasmic fraction and downregulation of several known Wnt target genes at the mRNA level [AXIN2, survivin (BIRC5), CCND1, MMP-7, c-MYC and ABCB1 (MDR1)]; ii) a reduction of cell proliferation; iii) a significant decrease in KKU-213B cell migration with RNF43 overexpression via upregulation of E-cadherin (CDH1); and iv) a reduction in N-cadherin (CDH2), MMP-2, MMP-7 and MMP-9. In addition, overexpression of RNF43 increased 5-fluorouracil sensitivity and downregulation of ABC transporter genes [including ABCB1 and ABCC1 (MRP1)]. The current results demonstrate a functional role for RNF43 in CCA by: i) Blocking β-catenin nuclear translocation; and ii) the subsequent downregulation of Wnt/β-catenin target genes (the latter being involved in the progression of CCA and chemotherapeutic drug susceptibility). Therefore, the present findings suggest that RNF43 could serve a tumour suppressive role in CCA.     

针刺结合扳机点穴位注射治疗原发性三叉神经痛临床观察

目的:观察针刺结合扳机点穴位注射治疗三叉神经痛的临床疗效.方法:72例随机分为治疗组和对照组各36例,治疗组用针刺结合扳机点穴位注射,对照组口服卡马西平治疗.结果:总有效率治疗组94.4％、对照组75.0％,两组比较差异有统计学意义(P＜0.05).两组视觉模拟评分(VAS)治疗前后组内比较及治疗后组间比较均差异有统计...     

腱性锤状指损伤机制与修复术式选择的解剖学研究

目的:探讨腱性锤状指损伤的解剖学机制,为采用伸肌腱断端直接缝合术治疗腱性锤状指损伤提供解剖学依据。方法:纳入成人新鲜手标本12只,解剖示、中、环、小指各12指的伸肌装置,观察掌指关节（MP）、近侧指间关节（PIP）和远侧指间关节（DIP）被动活动时伸肌腱与中节指骨头的接触情况,测量伸肌腱Ⅰ~Ⅱ区的最大滑程。伸直位固定伸...