Preventive effect of non-mitogenic acidic fibroblast growth factor on diabetes-induced testicular cell death

Fibroblast growth factor (FGF)-1 was found to protect the heart from oxidative damage, but clinically its long-term use was restricted for its undesirable proliferating activity on cells. Thus a cluster of amino acids responsible for the proliferation were deleted in the native FGF-1 to create a non-mitogenic FGF-1 (nmFGF-1). Whether the nmFGF-1 protects male germ cells from diabetes-induced apoptotic death was examined in diabetic mice induced with multiple low-doses of streptozotocin, followed by nmFGF-1 treatment for 6 months. Diabetic mice showed a decrease in testicular weight and an increase in apoptotic cell death. Treatment with nmFGF-1 alleviated the diabetic effects on testicular weight and apoptotic cell death. Mechanistically, nmFGF-1 may alleviate diabetes-induced germ cell death by decreasing the BAX/Bcl-2 ratio and endoplasmic reticulum stress as well as associated cell death, which is associated with Nrf-2 activation.     

Hydrocele accompanying testicular cavernous hemangioma: A infant case report

Testicular hemangioma is a rare benign testicular tumor. In this case we presented who an infant applied to our clinic with left scrotal swelling. The tests performed were found to be compatible with testicular hemangioma and accompanying hydrocele. We performed inguinal exploration due to hydrocele accompanying testicular hemangioma. Pathology of tissue was found to be compatible with testicular cavernous hemangioma. In our investigations, it was seen that it was the first infant cavernous hemangioma in the literature.     

Scattered radiation to gonads: Role of testicular shielding for para-aortic and homolateral illiac nodal radiotherapy

BackgroundScattered radiation to organs at risk deserves great attention during radiotherapy especially when the concern is about fertility. Minimizing the delivery of scattered radiation to the gonads while treating abdominal nodes or pelvic fields in male patients requires adequate shielding of the testes to preserve testicular functions. We constructed a testicular shield with cerrobend for the purpose of treatment of seminoma of testis stage I and IIA disease.Materials & methodsAn outer shell of coconut of required dimensions was taken as a base over which cerrobend was poured to obtain two semi-spherical half testicular shields. Five patients of seminoma early stage (stage I and IIA) were treated with this testicular shield.ResultsThe estimated total dose received by the testis by scatter radiation after completion of the treatment was 0.115 Gy (0.28%) of total mid-plane dose of 40 Gy delivered by inverted Y field. At a distance of 8 cm from the inferior field border the 2 cm thick cerrobend testicular shield provided a shielding factor of 3.2/0.3 = 10.33.ConclusionsWith proper testicular shielding, doses as low as 0.28% of the prescribed dose can be achieved. This low dose is believed to maintain the fertility of the patient.     

A rare cause of acute abdominal pain in adolescence: Hydrosalpinx leading to isolated torsion of fallopian tube

Torsion of the fallopian tube accompanying hydrosalpinx is a rare occurrence in the pediatric population. This report describes a 13 year old sexually inactive girl with isolated tubal torsion due to hydrosalpinx. The girl had lower left abdominal pain for two days. The physical examination revealed left lower quadrant tenderness with a firm round anterior mass on rectal examination. Abdominal ultrasound showed left tubal enlargement with free pelvic peritoneal fluid. Magnetic Resonance Imaging (MRI) showed engorgement and dilatation of the left fallopian tube without contrast enhancement suspicious of tubal torsion. At operation, torsion of the left tube on its longitudinal axis was observed, and a salpingectomy was performed.     

睾丸微石症合并精索静脉曲张36例分析

目的:探讨睾丸微石症合并精索静脉曲张患者的临床诊治方法,提高患者的睾丸储备功能。方法:回顾性报告并分析2011年3月至2013年2月36例睾丸微石症合并精索静脉曲张患者的病历资料,其中弱精症30例,精液质量正常6例。所有弱精症患者均行MV手术治疗,精液正常患者中1例CTM合并Ⅲ°VC有临床表现者行MV手术治疗,其余5例无临床表现患者无特殊处理;所有患者均每半年复查1次,彩色多普勒超声检查睾丸微石程度,精液CASA检查患者精液质量。结果:30例接受手术的弱精症患者有29例术后精液质量(精液密度,A+B级活动精子率,精子畸形率)明显改善,1例CTM患者精液质量及睾丸微石程度与手术前比较均无明显变化,且LTM患者的改善情况明显优于CTM患者,但所有患者的睾丸微石程度无明显变化;1例CTM合并Ⅲ°VC精液质量正常患者接受手术后精液质量及睾丸微石程度均无明显变化;1例CTM合并Ⅱ°VC和1例LTM合并Ⅲ°VC精液质量正常患者半年后精液出现异常,后接受MV手术治疗;2例LTM合并Ⅲ°VC精液质量正常患者2年后精液质量无变化,但其中1例睾丸微石程度加重,转为CTM;1例LTM合并Ⅰ°VC患者精液质量及睾丸微石程度无变化。结论:TM合并VC患者应该定期复查精液常规及泌尿生殖彩超,且MV手术对TM合并VC弱精症患者的精液质量有明显改善,LTM患者改善的程度明显优于CTM患者,对精液正常的患者可能会延缓精液质量恶化及睾丸微石程度加重。