阻塞性睡眠呼吸暂停综合征患者血清25-羟

目的 探讨在阻塞性睡眠呼吸暂停综合征患者中25-羟维生素D浓度与心脏结构异常的关系.方法 选择2010年8月至2012年4月住院的337例阻塞性睡眠呼吸暂停综合征患者,采用酶联免疫法测定血清25-羟维生素D浓度,超声心动图测量并计算左心室质量指数,定义左心室质量指数≥125 g/m2(男)、≥120 g/m2(女)为左心室肥厚.结果 (1)与轻至中度阻塞性呼吸睡眠暂停综合征(5次/小时≤睡眠呼吸暂停低通气指数＜ 30次/小时,n=111)组相比,重度阻塞性睡眠呼吸暂停综合征组(n =226)的左心室质量指数、左心室肥厚的发生率、体质指数显著增加(P＜0.01),血清25-羟维生素D浓度明显降低.(2)多元回归分析显示四分位数25-羟维生素D浓度与左心室肥厚发生具有独立相关性(校正OR =4.11,95％CI:1.15～12.70,P＜0.01),在校正肥胖及其他危险因素后,仍有相关性.另外,血清25-羟维生素D浓度与体质指数呈负相关.结论 血清25-羟维生素D浓度降低提示重度阻塞性睡眠呼吸暂停综合征患者发生左心室肥厚的可能性增加.     

胆汁反流性胃炎的中医研究述评

:从病名、病因病机、辨证分型、治疗规律等诸方面 ,对胆汁反流性胃炎的中医研究现状和进展进行了评述。认为今后应在胆汁反流性胃炎的中医病名研究 ,建立完整客观的诊断指标 ,完善辨证分型标准及疗效评定标准 ,加强实验研究等方面多做工作。以利于进一步提高中医药治疗本病的临床水平     

A study of abrupt lithium withdrawal

Twelve patients were abruptly switched from lithium to placebo as part of a double-blind cross-over study. In contrast to other drugs effective in mood disorders, lithium produced no withdrawal syndrome.     

Seromuscularis rupture of the oesophagus after vomiting: a rare cause of hemothorax

We report a case of seromuscularis rupture of the oesophagus occurring after an episode of vomiting and revealed by a left hemothorax. Diagnosis was established at thoracoscopy and was related to the nosologic setting of post-emetic syndromes. All unusual pleuropulmonary symptoms after vomiting must make evoke this diagnostic hypothesis.     

Cystic diseases of the kidney

Cystic diseases of the kidney constitute a heterogeneous family. Most renal cysts are benign and asymptomatic, and don't have any impact on renal function. These "simple" cysts are usually managed conservatively. However, some renal cysts may be symptomatic or may have atypical radiological presentation, leading to suspicion of malignant tumour; puncture or surgical investigation may be indicated in such cases. The other cystic renal diseases include specific entities, either genetic or acquired during development. Some malformative syndromes are often associated, and renal function may be impaired. In such cases, nephrectomy is required.     

Study of the intronic polymorphism of the angiotensin 1 converting enzyme among coronary Tunisians

Background

The acute coronary syndromes (ACS) are classified among the major causes of mortality in the industrialized countries. The increased angiotensin I converting enzyme (ACEI) activity related to a genetic polymorphism constitutes a hereditary predisposition to these syndromes.

Aim

Evaluate the ACEI activity in Tunisian patients with coronary heart disease, and investigate the association between this activity and an intronic deletion of 287 pb on the intron 16 of the ACEI gene.

Patients and methods

Seventy-two coronary patients and 34 control subjects are recruited for our study. ACEI activity was measured by kinetic method. The intronic deletion was identified by PCR technique.

Results

An increased activity of ACEI was observed in patients compared with control subjects (84.38 ± 33.83 UI/L vs 59.06 ± 18.2 UI/L, P = 10⁻⁵). The molecular study showed a raised relative frequency of D/D genotype (51.4%) among patients, whereas among the witnesses, I/I genotype prevailed (62%). D/D genotype is always associated with highest ACEI activity for the patients and the control subjects.

Conclusion

The molecular studies and the biochemical investigations of the various parameters of cardiovascular risk (including the ACEI) direct towards a better treatment.     

急性冠状动脉综合征患者外周血CD31~(bright)/Annexin V~+内皮微粒水平增高

目的 观察急性冠状动脉综合征患者与非冠心病患者外周血内皮微粒水平,探讨CD31bright/AnnexinV+内皮微粒与心血管危险因素的相关性.方法 急性冠状动脉综合征患者56例,非冠心病患者26例,采用流式细胞仪检测外周血CD31bright/Annexin V+内皮微粒水平.结果 与非冠心病患者比较,急性冠状动脉综合征患者外周血CD31bright/Annexin V+内皮微粒显著增加(P<0.01),而急性心肌梗死与不稳定型心绞痛亚组之间外周血CD31bright/Annexin V+内皮微粒水平无显著性差异(P>0.05).所有入选患者中,2型糖尿病患者外周血CD31bright/Annexin V+内皮微粒水平较非糖尿病患者显著升高(P<0.05);多因素回归分析显示,血清甘油三酯水平与外周血CD31bright/Annexin V+内皮微粒数量独立正相关(r=0.28,P<0.05).急性冠状动脉综合征组血清高敏C反应蛋白水平与外周血CD31bright/Annexin V+内皮微粒数量呈正相关(r=0.31,P<0.05).结论 急性冠状动脉综合征患者和糖尿病患者外周血CD31bright/Annexin V+内皮微粒增多,提示急性冠状动脉综合征患者和2型糖尿病患者内皮损伤严重.CD31bright/Annexin V+内皮微粒水平增高可能与血清甘油三酯和血清高敏C反应蛋白水平增高有关.     

脑卒中后疲劳中医证候分布特点研究

目的研究脑卒中后疲劳的基本证候及证候类型分布特点,并探讨疲劳严重度量表（FSS）评分与中医证候的关系。方法根据中医临床证候信息采集表收集信息,对我院符合纳入标准的126例缺血性脑卒中患者行FSS评分以分析中医证候分型。结果脑卒中后疲劳基本证候以气虚证、血瘀证占绝大多数,均超过总数73%;中医证候类型以气虚血瘀、气虚痰瘀、气阴两虚挟瘀三证最常见,且患者FSS评分明显高于风痰火亢、风痰瘀血、阴虚风动三证的FSS评分（P〈0.05）。结论脑卒中后疲劳中医证候类型以本虚标实证多见,以气虚血瘀、气虚痰瘀、气阴两虚挟瘀三证最常见。