全文获取类型
收费全文 | 8949篇 |
免费 | 1205篇 |
国内免费 | 177篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 107篇 |
妇产科学 | 135篇 |
基础医学 | 688篇 |
口腔科学 | 166篇 |
临床医学 | 582篇 |
内科学 | 1131篇 |
皮肤病学 | 45篇 |
神经病学 | 127篇 |
特种医学 | 319篇 |
外科学 | 4460篇 |
综合类 | 934篇 |
预防医学 | 379篇 |
眼科学 | 37篇 |
药学 | 610篇 |
1篇 | |
中国医学 | 472篇 |
肿瘤学 | 125篇 |
出版年
2024年 | 11篇 |
2023年 | 81篇 |
2022年 | 180篇 |
2021年 | 236篇 |
2020年 | 220篇 |
2019年 | 301篇 |
2018年 | 384篇 |
2017年 | 301篇 |
2016年 | 301篇 |
2015年 | 294篇 |
2014年 | 574篇 |
2013年 | 578篇 |
2012年 | 507篇 |
2011年 | 510篇 |
2010年 | 388篇 |
2009年 | 533篇 |
2008年 | 477篇 |
2007年 | 527篇 |
2006年 | 482篇 |
2005年 | 463篇 |
2004年 | 337篇 |
2003年 | 283篇 |
2002年 | 265篇 |
2001年 | 257篇 |
2000年 | 223篇 |
1999年 | 202篇 |
1998年 | 170篇 |
1997年 | 157篇 |
1996年 | 113篇 |
1995年 | 123篇 |
1994年 | 103篇 |
1993年 | 93篇 |
1992年 | 57篇 |
1991年 | 58篇 |
1990年 | 32篇 |
1989年 | 25篇 |
1988年 | 20篇 |
1987年 | 22篇 |
1986年 | 24篇 |
1985年 | 51篇 |
1984年 | 78篇 |
1983年 | 41篇 |
1982年 | 57篇 |
1981年 | 57篇 |
1980年 | 29篇 |
1979年 | 32篇 |
1978年 | 25篇 |
1977年 | 20篇 |
1976年 | 12篇 |
1969年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 29 毫秒
31.
本实验研究切除卵巢造成肾虚骨质疏松症大鼠模型。通过观测红细胞膜蛋白激酶C(PKC)和Ca2+-Mg2_-ATP酶的活性,探讨肾虎骨质疏松症病理机制中肌醇脂质系统的变化,并结合全身和脊柱骨密度(BMD)指标观察了补肾中药(密骨灵)的疗效,与正常对照组、模型空白组和阳性药(骨疏康颗粒剂)对照组进行对照,探讨补肾法的防治机理。结果表明;模型空白组大鼠红细胞膜PKC和Ca2+-Mg2+-ATP酶、Mg2+-ATP酶的活性明显低于正常组(p均<0.05);密骨灵组与骨疏康组大鼠全身、脊柱BMD和红细胞膜PKC、Ca2+-Mg2+-ATP酶的活性均明显高于模型空白组(p均<0.05),并且与正常组大鼠无明显差别(p均>0.05);密骨灵组大鼠红细胞膜Mg2+-ATP酶活性高于模型空白组和骨疏康组(p<0.05),并且与正常组无显著性差异(p>0.05);密骨灵组大鼠红细胞膜PKC活性高于骨疏康组(P<0.05)。结论:肾虎骨质疏松症具有红细胞膜PKC和Ca2+-Mg2+-ATP酶、Mg2+-ATP酶活性的改变;密骨灵可以恢复肾虎骨质疏松症大鼠全身骨量,达到防治目的;补肾中药可以恢复红细胞膜PKC活性和钙镁泵的活性,是补 相似文献
32.
Alpha2-HS glycoprotein phenotypes and quantitative hormone and bone measures in postmenopausal women
June E. Eichner Christopher A. Friedrich Jane A. Cauley Mohammad I. Kamboh James P. Gutai Lewis H. Kuller Robert E. Ferrell 《Calcified tissue international》1990,47(6):345-349
Summary It has been suggested that inherited traits play a role in the development of osteoporosis by providing a background for the
modulation of gene expression. In this study, we examine the influence of the different alleles of alpha2-HS glycoprotein (AHSG), a protein of the bone matrix, on quantitative estrogens, estrone and estradiol, and bone measures,
bone area and density. Estrogens provide a protective effect against fractures in older women and were thus included in the
analyses. Isoelectric focusing of AHSG from sera followed by immunoblotting was used to type 163 white post-menopausal women
participating in a clinical trial of the effects of walking on bone loss. Plasma hormones were measured by a combination of
extraction, column chromatography, and radioimmunoassay; bone measures on the dominant radius were determined with computerized
tomography. Analysis of variance was done on estrogen and bone measures after controlling for the effects of age and body
mass index. The two major alleles of AHSG result in three phenotypes, designated AHSG 1-1, AHSG 2-1, and AHSG 2-2. The AHSG
1-1 homozygote showed a decreased concentration of estradiol, the AHSG 2-2 homozygote showed an increased concentration, and
the AHSG 2-1 heterozygote was intermediate (P=0.001). Estrone demonstrated a similar pattern in residual analysis although it did not reach statistical significance. 相似文献
33.
大气中不同粒径颗粒物诱导人羊膜FL细胞UDS的研究 总被引:3,自引:0,他引:3
本研究以诱导人羊膜细胞UDS为指标,对太原市大气不同粒径的颗粒物提取液进行了致突变性检验,结果表明,不同粒径颗粒物的提取液均可产生一定的遗传毒性,尤以3.3μm以下的颗粒物的遗传毒性较强。 相似文献
34.
35.
D. Thiébaud P. Burckhardt M. Costanza D. Sloutskis D. Gilliard F. Quinodoz A.-F. Jacquet B. Burnand 《Osteoporosis international》1997,7(5):457-462
The relative importance of vitamin D deficiency, secondary hyperparathyroidism, nutritional deficiency and low bone mineral
density (BMD) as risk factors for hip fracture is not definitely established. In the framework of a case-control study of
risk factors for hip fractured, biochemical markers of bone metabolism and nutrition and femoral BMD data were compared in
136 female and 43 male hip fracture patients, 126 female and 44 male age-matched hospitalized controls, and 47 healthy elderly
women (8 men). Patients with hip fracture had lower albumin (−10%9 and 25(OH)-vitamin D (25(OH)D; −19%) compared with hospitalized
controls, and lower albumin (−28%) and 25(OH)D levels (−52%) compared with the elderly controls. Serum values of IGFBP-3 were
also significantly lower (−33%) in hip fracture patients than in community controls. BMD of femoral neck was lower (p < 0.001) in patients than in hospitalized and community controls. In hip fracture patients, parathyroid hormone (PTH) correlated
weakly with BMD (neck: r = −0.19, trochanter: r = −0.17; both p < 0.05). When all women were pooled (n = 233), albumin correlated significantly (age-adjusted) with BMD at all sites (neck: r = 0.27, trochanter: r = 0.25; all p < 0.001). Albumin, but not 25(OH)D, also correlated with skinfold thickness (r = 0.19, p < 0.0025) and with body mass index (BMI) (r = 0.14, p < 0.05). Male patients with hip fracture had lower BMD and albumin (both p < 0.001), 25(OH)D (p = 0.02) and IGFBP-3 levels (p <: 0.005) compared with the controls. When male patients and controls were pooled together, albumin, skinfold thickness and
BMI were significantly correlated with each other, but not with BMD. IGFBP-3 was highly correlated with albumin (p < 0.0001), 25(OH)D (p < 0.005) and, less significantly, with PTH (p < 0.05), but not with BMI or skinfold thickness. IGFBP-3 was significantly correlated with BMD at all sites (neck: r = 0.27, p < 0.05); trochanter: r = 0.40, p < 0.0005). In conclusion, low albumin and low BMD were both important risk factors for hip fracture. Low serum albumin was
the strongest independent variable correlated with hip fractures. In men, IGFBP-3 was correlated with BMD. The femoral BMD
depended only weakly on PTH and 25(OH)D, but was correlated at all sites with albumin, a non-specific parameter of nutrition
and general health. 相似文献
36.
37.
The aim of this study was to evaluate whether a prevalent vertebral deformity predicts mortality and fractures in both men and women. In the city of Malmö, 598 individuals (298 men, 300 women; age 50–80 years) were selected from the city's population and were included in the Swedish part of the European Vertebral Osteoporosis Study (EVOS). At baseline the participants answered a questionnaire and lateral spine radiographs were performed. The prevalence of subjects with vertebral deformity was assessed using a morphometric method. The mortality during a 10-year follow-up period was determined through the register of the National Swedish Board of Health and Welfare. Eighty-five men and 43 women died during the study period. The subsequent fracture incidence during the follow-up period was ascertained by postal questionnaires, telephone interviews and by a survey of the archives of the Department of Radiology in the city hospital. Thirty-seven men and 69 women sustained a fracture during the study period. Data are presented as hazard ratios (HR) with 95% confidence interval (95% CI) within brackets. Prevalent vertebral deformity, defined as a reduction by more than 3 standard deviations (SD) in vertebral height ratio, predicted mortality during the forthcoming decade in both men [age-adjusted HR 2.4 (95% CI 1.6–3.9)] and women [age-adjusted HR 2.3 (95% CI 1.3–4.3)]. In men there was an increased mortality due to cardiovascular and pulmonary diseases and in women due to cancer. Prevalent vertebral deformity predicted an increased risk of any fracture during the forthcoming decade in both men [age-adjusted HR 2.7 (95% CI 1.4–5.3)] and women [age-adjusted HR 1.8 (95% CI 1.1–2.9)]. Prevalent vertebral deformity predicted an increased risk of any subsequent fragility fracture in women [age-adjusted HR 2.0 (95% CI 1.1–3.5)]; however, in men the increased risk was nonsignificant [age-adjusted HR 1.9 (95% CI 0.7–5.1)]. In summary, a prevalent vertebral deformity can predict both increased mortality and increased fracture incidence during the following decade in both men and women. We conclude that prevalent vertebral deformity could be used as a risk factor in both genders for mortality and future fracture. 相似文献
38.
目的:建立骨钙素酶免疫测定方法,并应用于临床检测血清骨钙素。方法:应用了3种检测模式,根据检测灵敏度、剂量反应曲线的形态进行分析,选择出合适的模式进一步应用于临床血清标本的骨钙素检测。结果:所采用的骨钙素单克隆抗体是钙离子依赖型的。固相抗原竞争法适合于临床定量测定骨钙素。最低可测限为1.4μg/L;20μg/L骨钙素样品批内CV=3.98%,批间CV=12.67%。测定正常献血员140名(年龄17-45岁),第5-95百分位点的骨钙素含量,男性为7.5-15.0μg/L女性为7.0-17.5μg/L。70例疑有骨质疏松症患者血清骨钙素含量2.91-30.20μg/L,以第95百分位点的骨钙素含量为cut-off值,升高5例。与进口试剂盒(Novocalcin,USA)相比较,有较好的相关性,r=0.81。结论:固相抗原竞争法酶免疫测定可以灵敏地检测血清中骨钙素含量,有实用价值。 相似文献
39.
Osteoporosis in men is recognised worldwide as an important and increasing public health problem. The causes are more heterogeneous than those in women. About 50% are diagnosed as secondary cases. In some secondary forms of osteoporosis the specific diagnosis results in additional therapeutic options (e.g. androgen therapy in proven hypogonadism). The basic therapy for osteoporosis in men is no different to that in postmenopausal women, namely recommendations for counteracting modifiable risk factors, especially with regard to diet, physical exercise, and calcium and vitamin D supplementation. Concerning specific drug medications, however, even today there is still a therapeutic dilemma in male osteoporosis. While older substances (e.g. calcitonin, fluoride, alfacalcidol) are approved for both sexes, all newer medications have primarily been approved for the treatment of postmenopausal osteoporosis. Health authorities request studies in purely male populations. For new drugs, fracture data are necessary while for new substances within a class (e.g. bisphosphonates), at the very least consistent effects on bone mineral density (BMD) and bone turnover markers are requested. Due to these regulatory rules, ibandronate, teriparatide and strontium ranelate are not approved in the European Union. Some years ago, alendronate was the first bisphosphonate that was approved for the treatment of men with osteoporosis, based on consistent results from two independent male studies using a daily 10 mg dosage. Very recently risedronate was approved by the FDA and EMEA. A randomised, placebo-controlled multicentre trial of 285 male patients showed, after 2 years, a 5.8% increase in lumbar spine BMD in the risedronate 35 mg once weekly group vs 1.2% in the placebo group. In a prospective controlled study on 316 men with primary or secondary osteoporosis we found, after 12 months, a lumbar spine BMD of +4.7% vs +1.0% in controls. The number of patients with one or more new vertebral fractures was 8 in the risedronate group and 20 in the placebo group (a fracture reduction of 60%). Furthermore, we found a significantly smaller decrease in height and a steeper decrease in back pain in the risedronate group. Risedronate is the first oral bisphosphonate available for men with the more comfortable once weekly dosage. 相似文献
40.