排序方式: 共有147条查询结果,搜索用时 46 毫秒
141.
目的:明确NB-UVB对HaCaT细胞CCL22的影响。方法:常规培养后的HaCaT细胞分为两组,一组给予不同剂量NB-UVB (0、100、200、400 mJ/cm2)照射;一组给予NF-κB抑制剂PDTC(1、12.5、25 μmol/L)预处理后再进行NB-UVB照射,采用Real-time PCR及ELISA检测CCL22表达;采用Western blot方法检测NF-κB p65磷酸化水平。结果:CCL22表达和NF-κB p65磷酸化的水平随着NB-UVB照射剂量增强而上调;PDTC处理后,NB-UVB诱导的角质形成细胞CCL22表达及和NF-κB p65磷酸化水平较直接给予NB-UVB明显下调,且PDTC浓度越高越明显。 结论:NB-UVB照射可能通过激活NF-κB信号通路促进角质形成细胞CCL22表达及分泌。 相似文献
142.
目的观察窄谱中波紫外线(NB-UVB)联合抗组胺药治疗慢性自发性荨麻疹的疗效。方法 80例慢性荨麻疹患者,随机分为试验组和对照组,每组各40例。试验组采用NB-UVB光疗,每周2次,共24次,同时口服抗组胺药;对照组仅口服抗组胺药。比较两组治疗后的临床疗效以及随访12周内的复发情况。结果两组患者的症状和体征评分明显下降,且试验组下降更为明显(t=46.37,P0.05)。试验组的临床疗效明显优于对照组(χ~2=6.76,P0.05);且复发率明显低于对照组(χ~2=9.83,P0.01)。结论 NB-UVB安全有效,可作为慢性自发性荨麻疹的辅助治疗手段。 相似文献
143.
许功军 《中国麻风皮肤病杂志》2015,31(1)
目的:评价NB-UVB联合他克莫司软膏治疗面部脂溢性皮炎的疗效及安全性.方法:140例面部脂溢性皮炎患者随机分为2组,治疗组70例采用NB-UVB照射联合他克莫司软膏外用;对照组70例,外用他克莫司软膏,每日2次,治疗4周后评估疗效及不良反应.结果:治疗组的总有效率为94.29%,明显高于对照组(77.14%),差异有统计学意义(P<0.05).两组均未见明显不良反应.结论:NB-UVB照射联合他克莫司软膏外用治疗面部脂溢性皮炎安全有效. 相似文献
144.
中药药浴联合NB-UVB照射治疗寻常性银屑病疗效观察 总被引:2,自引:0,他引:2
目的观察中药药浴联合窄谱中波紫外线(NB-UVB)照射治疗寻常性银屑病的临床疗效。方法将入选的283例寻常性银屑病患者按门诊及住院顺序编号,采用随机数字表法分成3组。对照1组以NB-UVB全身照射;对照2组以中药煎液沐浴;治疗组为中药药浴联合NB-UVB照射,方法同前两组。3组均2周为1个疗程,2个疗程后判定疗效。结果治疗组有效率为94.38%,对照1组为84.38%,对照2组为69.89%,治疗组疗效优于对照组1组和2组,差异均有统计学意义(χ21组=4.8,P<0.05;χ22组=18.37,P<0.01)。治疗组复发率(10.81%)及不良反应(11.24%)低于对照组1组(分别为30.30%和23.96%),差异均有统计学意义(χ2=4.14,5.10;P均<0.05)。结论中药药浴联合NB-UVB照射治疗寻常性银屑病疗效较好,可缩短疗程,降低复发率及不良反应。 相似文献
145.
目的探讨窄谱中波紫外线(NB-UVB)对银屑病患者皮损中微血管密度(MVD)和血清血管内皮生长因子(VEGF)水平的影响。方法用血管内皮细胞特异性标志物CD34抗体免疫组化法检测银屑病患者NB-UVB治疗前后皮损中的MVD,用ELISA方法检测患者NB-UVB治疗前后血清VEGF的水平。结果银屑病患者NB-UVB治疗前的MVD明显高于治疗后及正常对照组(P均<0.01)。银屑病患者NB-UVB治疗前的血清VEGF水平明显高于治疗后及正常对照组(P均<0.01)。结论NB-UVB可能通过抗血管新生作用来治疗银屑病。 相似文献
146.
目的:观察阿维A胶囊联合窄谱中波紫外线治疗斑块型银屑病的疗效。方法:161例患者随机分为3组,治疗组口服阿维A胶囊,配合NB-UVB照射;对照组1只口服阿维A胶囊;对照组2单独应用NB—UVB照射治疗。结果:治疗3、6、9周时治疗组有效率均高于对照组1和对照组2,组间比较差异均有统计学意义(P〈0.005)。结论:阿维A联合NB-UVB治疗斑块型银屑病,可增加患者对光疗的敏感性,减少光疗的量和治疗时间,同时也减少阿维A的用量,从而减少副作用的发生,在临床中值得推广。 相似文献
147.
Akman A Dicle O Yilmaz F Coskun M Yilmaz E 《Photodermatology, photoimmunology & photomedicine》2008,24(3):123-127
Background: Previous reports showed that serum levels of vascular endothelial growth factor (VEGF) are increased in patients with psoriasis. However, to our knowledge, no studies have evaluated the effects of PUVA, Re-PUVA and narrow-band UVB (NB-UVB) treatments on serum levels of VEGF in patients with psoriasis.
Objective: The aim of the study was to evaluate the influence of PUVA, Re-PUVA and NB-UVB treatments on angiogenic activities in patients with psoriasis by comparing serum levels of VEGF.
Methods: Forty-six patients with psoriasis and 20 healthy subjects were included in the study. Peripheral blood samples were collected before, during and after the therapies. The efficacy of PUVA, Re-PUVA and NB-UVB was delineated by the psoriasis area and severity index. A repeated measure of ANOVA, Mann–Whitney U -test, χ2 and Pearson's correlation coefficient were used for statistical analysis.
Results: The VEGF levels were significantly decreased in the PUVA group at the end of the follow-up period ( P <0.001). However, the levels were significantly increased in the groups of NB-UVB and Re-PUVA ( P <0.001).
Conclusions: We found that there was a discrepancy during the PUVA, Re-PUVA and NB-UVB treatments. We believe that VEGF plasma levels could not be a useful monitor of psoriasis activity and/or treatment response. 相似文献
Objective: The aim of the study was to evaluate the influence of PUVA, Re-PUVA and NB-UVB treatments on angiogenic activities in patients with psoriasis by comparing serum levels of VEGF.
Methods: Forty-six patients with psoriasis and 20 healthy subjects were included in the study. Peripheral blood samples were collected before, during and after the therapies. The efficacy of PUVA, Re-PUVA and NB-UVB was delineated by the psoriasis area and severity index. A repeated measure of ANOVA, Mann–Whitney U -test, χ
Results: The VEGF levels were significantly decreased in the PUVA group at the end of the follow-up period ( P <0.001). However, the levels were significantly increased in the groups of NB-UVB and Re-PUVA ( P <0.001).
Conclusions: We found that there was a discrepancy during the PUVA, Re-PUVA and NB-UVB treatments. We believe that VEGF plasma levels could not be a useful monitor of psoriasis activity and/or treatment response. 相似文献