Intracardiac teratoma in a newborn

Primary tumors of the heart are infrequent at all ages. We present a newborn with hypoxia and a heart murmur, in whom an echocardiogram revealed a large tumor filling the right ventricle and the pulmonary annulus. To maintain pulmonary blood flow, the patency of the ductus arteriosus was achieved by infusion of prostaglandin E1. Successful surgical resection was accomplished. The pathological examination was characteristic of a benign teratoma. The patient remains asymptomatic and has shown no evidence of recurrence of the tumor during a follow-up period of 34 months. This represents the eleventh case of intracardiac teratoma and only the fourth case to undergo successful surgical resection.     

iRoot BP Plus在成熟恒牙活髓保存治疗中的疗效分析

目的 评价iRoot BP Plus用于成熟恒牙活髓保存治疗(直接盖髓术和部分活髓切断术)的临床疗效.方法 选取120例共120颗因龋露髓成熟恒牙牙髓炎患者,随机分为A(直接盖髓术)、B(部分活髓切断术)和C(根管治疗术)3组,每组40例,术后第3、6、12个月复查,综合评价3组的疗效、发生不良反应和患者满意度的差异.结果 3组患牙治疗效果均较好:术后3个月,A、B、C组的治疗成功率分别是92.5％、97.5％、95.0％;术后6个月,3组分别是90.0％、95.0％、92.5％;术后12个月,3组分别是90.0％、95.0％、90.0％.在不同时间段,3组之间治疗的成功率和术后不良反应发生率的差异均无统计学意义(P>0.05).A、B两组的患者综合满意度明显高于C组(P<0.05).结论 iRoot BP Plus用于因龋露髓的成熟恒牙活髓保存治疗,疗效可靠,可以避免根管治疗所产生的术后并发症,值得临床推广.     

卵巢成熟性畸胎瘤伴甲状腺肿类癌1例及文献复习

目的:探讨1例卵巢成熟性畸胎瘤伴甲状腺肿类癌的临床病理特征。方法:对1例诊断为卵巢成熟性畸胎瘤伴甲状腺肿类癌患者的临床资料、组织学形态及免疫组化结果进行分析,并对相关文献进行复习。结果:本例为卵巢成熟性畸胎瘤伴甲状腺肿类癌,病理学检查除成熟性畸胎瘤成分外,另见由甲状腺和类癌组织混合成的结节一枚,类癌细胞较小且大小相仿,染色质均匀,核分裂少见,免疫组化:甲状腺滤泡上皮细胞TG(+)、TTF-1(+),类癌细胞CD99(+)、Cg A(+)、Syn(+)、CK7(-)。结论:卵巢成熟性畸胎瘤伴甲状腺肿类癌为罕见的病变,临床患者多无典型症状,且类癌成分多与甲状腺组织混杂于畸胎瘤中,容易漏诊,故应广泛取材并提高对卵巢成熟性畸胎瘤伴甲状腺肿类癌组织学特征及免疫表型的认识,对累积资料,避免临床误诊、漏诊具有重要的价值。     

Endometriosis coexisting with mature cystic teratoma in the same ovary and ectopic pregnancy of left fallopian tube: a rare coexistence

A coexistence of endometriosis and mature cystic teratoma in the same ovary is a rare occurrence although such tumors of ovaries are said to be common in the reproductive age group. We report a case of fimbrial ectopic pregnancy combined with simultaneous ipsilateral ovarian presentation of endometriosis and mature teratoma.     

Topographical variations in articular cartilage and subchondral bone of the normal rat knee are age-related

In osteoarthritis animal models the rat knee is one of the most frequently investigated joint. However, it is unknown whether topographical variations in articular cartilage and subchondral bone of the normal rat knee exist and how they are linked or influenced by growth and maturation. Detailed knowledge is needed in order to allow interpretation and facilitate comparability of published osteoarthritis studies. For the first time, the present study maps topographical variations in cartilage thickness, cartilage compressive properties and subchondral bone microarchitecture between the medial and lateral tibial compartment of normal growing rat knees (7 vs. 13 weeks). Thickness and compressive properties (aggregate modulus) of cartilage were determined and the subchondral bone was analyzed by micro-computed tomography. We found that articular cartilage thickness is initially homogenous in both compartments, but then differentiates during growth and maturation resulting in greater cartilage thickness in the medial compartment in the 13-week-old animals. Cartilage compressive properties did not vary between the two sites independently of age. In both age-groups, subchondral plate thickness as well as trabecular bone volume ratio and trabecular thickness were greater in the medial compartment. While a high porosity of subchondral bone plate with a high topographical variation (medial/lateral) could be observed in the 7-week-old animals, the porosity was reduced and was accompanied by a reversion in topographical variation when reaching maturity. Our findings highlight that there is a considerable topographical variation in articular cartilage and subchondral bone within the normal rat knee in relation to the developmental status.     

卵巢未成熟型畸胎瘤合并抗NMDA受体脑炎2例报告

1 病例资料 病例1为28岁女性患者,已婚已育,因“记忆力减退18 d,加重伴胡言乱语、意识减退1周”收入我院神经内科.患者入院前30 d前出现进行性的记忆力减退、幻听,进而出现哭闹、唱歌、手舞足蹈等异常行为,并伴有呕吐、发热、抽搐等症状.曾于当地医院检查脑电图未见癫痫波,全腹部CT平扫示:盆腔巨大占位,考虑畸胎瘤可能.胸部CT提示:双肺炎症伴双侧胸腔积液.为进一步治疗于2015年6月18日至我院神经内科就诊,拟“颅内感染:继发性癫痢,畸胎瘤?肺部感染”收入院.入院后检查:神志浅昏迷,言语不能;双侧瞳孔直接、间接对光反射均迟钝;眼泪多,口水多,四肢肌张力减弱,肌力不配合,颈软稍微抵抗,Kemig征(+).血清肿瘤标记物CA125 119.8U/mL,SCC-Ag 3.9 ng/mL,血清抗N-甲基-D-天冬氨酸(antiN-methyl-D-aspartate,NMDA)受体抗体阳性,脑脊液抗NMDA受体抗体阳性.妇科超声检查提示:盆腔巨大混合性包块(约12 cm×9 cm),畸胎瘤可能.修正诊断:抗NMDA受体脑炎,畸胎瘤.入院后予以头孢曲松钠抗感染,更昔洛韦抗病毒,氯硝西泮、托吡酯控制癫痫发作,同时予以甲泼尼龙、丙种球蛋白、环磷酰胺免疫抑制,血浆置换2次.患者经治疗后无癫痫持续发作,但仍处于昏睡状态,治疗效果欠满意.经我院妇产科、神经内科、麻醉科专家会诊后于2015年7月10日行全麻下剖腹探查术.术中见:左侧卵巢肿瘤,直径约25 cm,表面有破口,子宫大小正常,活动可,右侧卵巢表面见约2 cm×1.5 cm囊肿,双侧输卵管外观正常.     

Chordoma arising in a mature cystic teratoma of the ovary: a case report

Mature cystic teratoma of the ovary (MCTO) is the most common type of ovarian teratoma and also the most frequent tumor originating from germ cells. It is usually diagnosed in early adulthood and, by definition, is composed of well-differentiated tissues, which originate from all three germ cell layers. Unusual types of tissues can be found in MCTO, such as kidney, adrenal, and prostatic tissues. Malignant transformation is reported in less than 2% of teratomas. Squamous cell carcinoma is the most common malignancy arising in these otherwise benign tumors. We present the first case of MCTO containing a chordoma. The chordoma differentiation was supported by immunohistochemical staining and interphase fluorescence in situ hybridization (IP-FISH) technique showing 19% of the nuclei of the MCTO displaying polysomy for the chromosome X, while 28% of the chordoma nuclei showed chromosome 7 mosaicism. These results are concordant with previous studies, showing chromosomal anomalies in chromosomes X and 7 in MCTO and chordomas, respectively.