躯体形式障碍的治疗分析

目的探讨躯体形式障碍的治疗方法。方法用钟友彬的认识领悟疗法对躯体形式障碍3案例治疗通程予以报告和分析。结果认识领悟疗法对躯体形式障碍有一定的临床治疗效果。结论认识领悟疗法治疗躯体形式障碍是有效的和可行的。     

胰岛素、可地松和已烯雌酚处理妊娠早期小鼠对其胚胎发育的影响

本文用不同剂量的胰岛素、可地松、已烯雌酚,作用于妊娠开始至80小时的昆明小鼠,然后观察胚胎早期(植入前)和胚胎晚期(妊娠18天)的胚胎数量、发育时期及其与黄体数相比成活率的变化。实验表明,用较大剂量激素处理后,早期胚胎的上述各项指标,均表现出十分明显的抑制效果。当剂量逐渐降低后,仍表现出不同程度的抑制作用,只是逐渐趋于正常。所用各种激素对晚期胚胎的影响,表现在除部分死亡外,存活者的生长和发育一直落后。说明妊娠早期小鼠体内某些激素的水平,不仅直接影响早期,而且也影响晚期胚胎的发育。     

TP73-AS1在肿瘤中的表达及调控作用

<正>随着高通量测序技术的发展,成千上万种长链非编码RNA(long non-coding RNA,lncRNA)进入人们的视野。lncRNA是一类长度超过200个核苷酸并缺少开放阅读框的不具备蛋白质编码功能的RNA~([1-2])。研究发现lncRNA参与诸多生物学进程的关键步骤,包括染色质重塑、基因转录、转录后调节和蛋白质翻译等~([3-5])。LncRNA机制的不断被阐明,也为肿瘤的研究提供了新的可能。LncRNA在多种肿瘤的增殖、迁移侵袭和抗凋亡     

Pemphigus vulgaris: the role of IL-1 and IL-1 receptor antagonist in pathogenesis and effects of intravenous immunoglobulin on their production

Intravenous immunoglobulin (IVIG) is increasingly being used for the treatment of autoimmune diseases. In the present report, the role of IVIG on in vivo and in vitro production of IL-1 and IL-1 receptor antagonist (Ra) was studied in patients with pemphigus vulgaris (PV). Serum samples from 20 untreated patients with active PV prior to initiation of systemic therapy, 20 patients receiving IVIG treatment, 20 patients in clinical remission after conventional therapy, and 20 normal human controls were studied to determine the serum levels of IL-1alpha, IL-1beta, and IL-1Ra. The in vitro production of these cytokines was measured in the culture supernatant of peripheral blood mononuclear cells (PBMC) from 10 PV patients immediately before and after IVIG therapy and from age and sex-matched 10 healthy donors simultaneously. Elevated levels of IL-1alpha and IL-1beta were detected (i) in the serum of untreated PV patients with active disease prior to systemic therapy and (ii) before IVIG infusions in patients receiving IVIG therapy. These increased levels are statistically significant when compared to the levels in healthy controls (P < 0.01). A marked reduction of IL-1alpha and IL-1beta was detected (i) in the serum of patients in prolonged clinical remission and (ii) immediately after IVIG infusion in those patients on IVIG therapy. Increased level of IL-1Ra was detected in PV patients in prolonged clinical remission and after IVIG infusion in those receiving IVIG therapy. These differences were statistically significant when compared to the levels in normal controls and to the levels in the sera of patients with active disease (P < 0.01) or just before the beginning of IVIG infusion (P < 0.01). Similar differences in the levels of IL-1alpha, IL-1beta, and IL-1Ra were found in the culture supernatant of PBMC isolated from the PV patients pre and post IVIG therapy. These observations suggests that, compared to normal controls, patients with active PV have reversed levels of IL-1alpha, IL-1beta, and IL-1Ra. IVIG therapy may down-regulate production of IL-1alpha and IL-1beta and enhance production of IL-1Ra, in vivo and in vitro. This might be one of the important mechanisms by which IVIG produces its early therapeutic effects in pemphigus vulgaris.     

首诊强迫症患者的临床特点与心理防御机制研究

目的：探讨首次诊断为强迫症（OCD）患者的临床特点及其与心理防御机制的关系。方法：42例强迫症患者用耶鲁-布朗强迫评定量表（Y—BOCS）、汉米顿焦虑量表（HAMA）、汉米顿抑郁量表（HAMD）、防御方式问卷（DSQ）和艾森克人格问卷（EPQ）进行评定并与42例正常对照者比较。结果：强迫症患者以强迫观念或强迫行为为主要表现的和混合状态的各占近一半，强迫检查和强迫联想出现的频率较高，约5／6的患者有两种以上的症状，混合型的患者病程长且症状较重：强迫症患者与对照组相比更多地使用被动攻击、潜意识显现、分裂、幻想、退缩等不成熟防御机制和中间型防御机制．而较少使用升华等成熟防御机制：强迫症患者EPQ中的神经质标准分（N）显著高于对照组，而内-外向标准分（E）则低于对照组。三种不同类型的强迫症患者之间的心理防御机制以及EPQ问卷各因子的标准分的差异无显著性、结论：三组首诊的OCD患者具有不同的临床特征；不同类型的OCD均较多的使用不成熟和中间的防御机制且多具有内向、神经质的个性。     

鞭毛抗原与细菌的群集运动

群集运动是指在培养基表面某些运动细菌依赖鞭毛的群体迁移行为,涉及繁殖体细胞分化成群集细胞,发生形态、代谢以及蛋白表达等显著变化。菌细胞密度、表面接触和生理学信号均可成为群集运动的刺激因素。群集运动的关键是鞭毛的生物合成,flhDC鞭毛操纵子是支配分化和迁移的细菌调控网络的焦点。     

幽门螺杆菌疫苗免疫机制的研究进展

幽门螺杆菌(H.pylori)是定植于人体胃粘膜的重要致病菌,而粘膜疫苗以其有效的保护性免疫成为防治H.pyiori的热点,但对相应的免疫机制的认识目前尚不明确.故本文对H.pyiori疫苗的保护性免疫机制中的抗原递呈机制,抗体的作用以及TH细胞反应的作用等研究进展做一概要介绍.     

The early phase of experimental acute renal failure

Experiments were conducted to establish whether diminished solute reabsorption in the loop of Henle during acute renal failure could explain the loss of urinary concentration and participate in generating a tubuloglomerular feedback-mediated reduction in filtration rate. The electrolyte content of the fluid in the ascending limb of the loop of Henle was determined in situ by monitoring its electrical conductivity after propulsion into the distal tubule with a sudden burst perfusion. The value of the minimum electrolyte concentration decreased exponentially with increasing equilibration time, reaching a steady-state value equivalent to 27±9 mM NaCl in normal kidneys, 34±15 mM in mercuric chloride kidneys and 53±22 mM following ischaemia. A mathematical model was derived to describe the process of sodium chloride dilution from which it was possible to calculate both the permeability and transport velocity of the cortical thick ascending limb. In the normal kidney, the transport velocity was calculated to be 4.65±0.92 ·10^–5 cm/s, a value not significantly different from that of the mercuric chloride or ischaemic kidneys, and the estimated permeability was 1.13±0.52·10^–5 cm/s, not different from that of the mercuric chloride kidneys but significantly lower than that calculated for the ischaemic kidneys. It is concluded that for the more severely damaged ischaemic model, the loss of urinary concentrating ability was accompanied by a reduction in diluting ability of the ascending limb of the short loop of Henle, which appears to be due, at least in part, to an elevation of the passive permeability to sodium chloride in this segment.