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81.
目的:重点研究和探讨新型过氧乙酸溶液消毒消化内镜的效果。方法:利用回顾性分析方法,总结我院于2012年1月1日~2013年12月3日天这段时间使用的总计138例消化内镜消毒情况,将其按照消毒方法不同随机分配成2个组,其中对照组患者为69例均采用2%戊二醛进行消毒;观察组患者为69例均采用新型过氧乙酸溶液进行消毒。然后将2组消化内镜消毒效果进行比较,分析探讨2组消化内镜的消毒合格率。结果:观察组消化内镜消毒后总合格率为100.00%,对照组消化内镜消毒后总合格率为94.20%,观察组消化内镜消毒后总合格率好于对照组消化内镜消毒后的总合格率,2组间比较存在显著性的差异(P<0.05)。结论:新型过氧乙酸溶液消毒消化内镜具有显著的效果,而且显著提高了消化内镜的消毒合格率,为使用消化内镜治疗的患者提供更高的保障,对我国消化内镜的使用发展具有重要价值,值得借鉴和推广。  相似文献   
82.
罗淑君 《吉林医学》2013,(30):6332-6333
目的:探讨新型过氧乙酸溶液应用于消化内镜消毒的临床效果。方法:消化内镜100例,随机分成对照组与观察组,每组50例。对照组应用2%戊二醛溶液,观察组应用新型过氧乙酸溶液。结果:观察组总合格率100%与对照组96.00%相比,差异无统计学意义(P>0.05)。结论:新型过氧乙酸溶液应用于消化内镜消毒效果比较可靠,且对内镜无损伤,具有良好的安全性。  相似文献   
83.
林曦 《医学综述》2011,17(14):2084-2087
应用带瓣管道重建右心室流出道是治疗复杂先天性心脏病的一项重要手段。近年来,戊二醛处理的牛颈静脉带瓣管道被广泛应用于临床,但术后管道钙化、衰败问题一直未得到解决。目前抗钙化处理方法有去细胞、染料介导光氧化、环氧化合物、组织工程等,但单一方法往往不能取得令人满意的效果,多种方法联合处理将是组织工程技术发展的方向。  相似文献   
84.
Knee meniscus replacement holds promise, but current allografts are susceptible to biodegradation. Matrix stabilization with glutaraldehyde, a crosslinking agent used clinically to fabricate cardiovascular bioprostheses, or with glycation, a process of crosslinking collagen with sugars such as ribose, is a potential means of rendering tissue resistant to such degradation. However, stabilization should not significantly alter meniscal material properties, which could disturb normal function in the knee. Our objective was to evaluate the effects of glutaraldehyde- and glycation-induced matrix stabilization on the material properties of porcine meniscus. Normal untreated meniscus specimens were tested in confined compression at one of three applied stresses (0.069, 0.208, 0.347 MPa), subjected to either a glutaraldehyde or glycation stabilization treatment, and then re-tested to measure changes in tissue aggregate modulus, permeability, and compressive strain at equilibrium. Changes in these properties significantly increased with glutaraldehyde concentration and exposure time to ribose. One glutaraldehyde and three glycation treatments did not alter aggregate modulus or compressive strain at equilibrium compared to controls (p > 0.10). However, all treatments increased permeability by at least 108% compared to controls (p < 0.001). This study reveals a dose-dependent relationship between meniscal material properties and certain stabilization conditions and identifies treatments that minimally affect these properties. Further research is necessary to determine whether these treatments prevent enzymatic degradation before and after surgical implantation in the knee.  相似文献   
85.
表面活性剂对戊二醛消毒液稳定性的研究   总被引:2,自引:0,他引:2  
目的:研究寻找一种使2%戊二醛消毒液既无腐蚀性又稳定的试剂。方法:用0.25%非离子型表面活性剂苄泽35或OP-10替代3%NaHCO3。对取代后的2%戊二醛消毒液采用恒温法在40℃,60℃及80℃进行稳定性试验,留样观察及其对医疗器械的腐蚀性考察。含量测定方法按照《中国医院制剂规范》第1版的方法进行测定。结果:用苄泽35取代后的2%戊二醛消毒液在稳定性试验及留样观察中,消耗H2SO4滴定液(0.05000mol/L)的毫升数仍在限度:3.6-4.4ml之间;浸包5个月后的医疗器械光滑,无斑点。结论:取代后的2%戊二醛消毒液的稳定性高,对医疗器械无腐蚀。  相似文献   
86.
因印模等直接与病人唾液、血液、食物残渣接触,成为重要疾病传染源之一。本实验研究紫外灯照射模型、2%戊二醛浸泡印模和(牙合)蜡的消毒效果,结果提示两者均能快速有效地杀灭细菌,切断通过印模等传播疾病的途径。  相似文献   
87.
Tyrosinase from the banana peel (TBp) served as a low-cost immobilized biocatalyst for the production of 3, 4-di hydroxyphenyl-l-alanine (l-DOPA). l-DOPA, a dopamine precursor, useful in the management of Parkinson's disease, was produced in improvised reactors. l-DOPA production by the immobilized TBp was optimized via response surface methodology (RSM). l-DOPA productivities obtained at equimolar substrate concentrations and 500 mg of TBp for the packed bed and batch process (BP) were 34.0 ± 2.1 and 15.4 ± 0.9 mg/L/h respectively. The resulting l-DOPA productivity in the BP after the RSM model validation was 63 ± 3.0 mg/L/h. There was a good fit with the model obtained based on the closeness of the predicted and experimental values. After four successive batch processes, about 35% loss in l-DOPA productivity was observed. In conclusion, banana peel served as a relatively cheap and easily available source of tyrosinase for the production of l-DOPA in both batch and packed bed reactors.  相似文献   
88.

Purpose

The purpose of this in-vitro study was to evaluate the effect of 0.5% glutaraldehyde spray disinfection on surface wettability of vinyl polysiloxane and polyether impression materials.

Methods and materials

Thirty-six specimens were prepared of vinyl polysiloxane-light (VPL), vinyl polysiloxane-regular (VPR) viscosity and polyether-monophase (PE) impression materials according to manufacturer’s recommendations. Specimens of each material were equally divided into control and experimental groups. All specimens were washed with water, dried and stored in closed containers. Specimens of experimental groups were sprayed with 0.5% glutaraldehyde disinfectant. The disinfectant was allowed to be in contact with the impression surface for 10?min. Contact angle was measured using a Contact Angle Goniometer at 0.5, 1 and 2?min after water drop contact with surfaces of impression materials. Five measurements at five different areas at each impression surface were recorded. A statistical analysis was done using Two-way repeated measures ANOVA and multiple comparison Tukey’s Post-hoc tests.

Results

All 0.5% glutaraldehyde-disinfected impression materials showed lower contact angle measurements than non-disinfected ones. Contact angle measurements of PE were much lower than those of VPL and VPR impression materials. However, there was a statistically significant difference of contact angle measurements between the three impression materials (p?=?0.000). Contact angle measurements of all groups significantly decreased as the time was increased (p?=?0.000).

Conclusion

Disinfection of the tested impression materials with 0.5% glutaraldehyde improved their wettability. Glutaraldehyde acted like a surface reducing agent (surfactant) that improved wetting potential of the impression materials.  相似文献   
89.
目的为靶向超声造影剂的制备进行基础实验研究。方法将含氟烷人血白蛋白超声造影剂与ICAM-1抗体混合,加入0.1%戊二醛,4℃孵育2h,促使抗体与微泡外壳充分交联。普通光镜评估靶向微泡的大小、形态。免疫荧光法进行靶向微泡的鉴定。结果普通光镜下可见携ICAM-1抗体的靶向微泡大小、形态与普通白蛋白微泡对照无明显改变。荧光显微镜证实微泡与ICAM-1抗体整合成功。结论戊二醛交联法适用于白蛋白靶向超声造影剂的制备,方法简便,成本低,重复性好。  相似文献   
90.
目的:对邻苯二甲醛在消化内镜消毒应用中的消毒效果、经济学指标、安全性进行系统评价。方法:计算机检索中国生物医学文献服务系统、中国知网资源总库(CNKI)、万方数据知识服务平台、维普期刊资源整合服务平台(VIP),纳入国内邻苯二甲醛对比戊二醛在消化内镜消毒效果、经济学指标、安全性三方面的对照研究,检索时间截至2016年7月。对研究结果进行定性分析。结果:最终纳入14项对照研究,但存在较大的异质性。定性分析结果显示:12项研究的消毒效果对比结果显示邻苯二甲醛浸泡5分钟与戊二醛浸泡≥10分钟无差异,均可达到高水平消毒。9项研究的经济学指标对比结果显示邻苯二甲醛耐用性更好,消毒效率更高,经济效益更佳。并且邻苯二甲醛的安全性优于戊二醛。结论:邻苯二甲醛可替代戊二醛成为消毒消化内镜的首选高水平消毒剂。  相似文献   
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